Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation

Learning and memory depend on morphological and functional changes to neural spines. Non-muscle myosin 2b regulates actin dynamics downstream of long-term potentiation induction. However, the mechanism by which myosin 2b is regulated in the spine has not been fully elucidated. Here, we show that...

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Main Authors:	Yagi, Hideshi, Nagano, Takashi, Xie, Min-Jue, Ikeda, Hiroshi, Kuroda, Kazuki, Komada, Munekazu, Iguchi, Tokuichi, Rahman, Mohammad Tariqur, Morikubo, Soichi, Noguchi, Koichi, Murase, Kazuyuki, Okabe, Masaru, Sato, Makoto
Format:	Article
Language:	English
Published:	Nature Publishing Group 2014
Subjects:	QP Physiology
Online Access:	http://irep.iium.edu.my/38350/ http://irep.iium.edu.my/38350/ http://irep.iium.edu.my/38350/1/Tariqur.pdf

id	iium-38350
recordtype	eprints
spelling	iium-383502018-06-11T07:00:32Z http://irep.iium.edu.my/38350/ Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation Yagi, Hideshi Nagano, Takashi Xie, Min-Jue Ikeda, Hiroshi Kuroda, Kazuki Komada, Munekazu Iguchi, Tokuichi Rahman, Mohammad Tariqur Morikubo, Soichi Noguchi, Koichi Murase, Kazuyuki Okabe, Masaru Sato, Makoto QP Physiology Learning and memory depend on morphological and functional changes to neural spines. Non-muscle myosin 2b regulates actin dynamics downstream of long-term potentiation induction. However, the mechanism by which myosin 2b is regulated in the spine has not been fully elucidated. Here, we show that filamin A-interacting protein (FILIP) is involved in the control of neural spine morphology and is limitedly expressed in the brain. FILIP bound near the ATPase domain of non-muscle myosin heavy chain IIb, an essential component of myosin 2b, and modified the function of myosin 2b by interfering with its actin-binding activity. In addition, FILIP altered the subcellular distribution of myosin 2b in spines. Moreover, subunits of the NMDA receptor were differently distributed in FILIP-expressing neurons, and excitation propagation was altered in FILIP-knockout mice. These results indicate that FILIP is a novel, region-specific modulator of myosin 2b. Nature Publishing Group 2014-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/38350/1/Tariqur.pdf Yagi, Hideshi and Nagano, Takashi and Xie, Min-Jue and Ikeda, Hiroshi and Kuroda, Kazuki and Komada, Munekazu and Iguchi, Tokuichi and Rahman, Mohammad Tariqur and Morikubo, Soichi and Noguchi, Koichi and Murase, Kazuyuki and Okabe, Masaru and Sato, Makoto (2014) Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation. Scientific Reports, 4 (6353). pp. 1-13. ISSN 2045-2322 http://www.nature.com/srep/2014/140815/srep06353/full/srep06353.html#affil-auth
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QP Physiology
spellingShingle	QP Physiology Yagi, Hideshi Nagano, Takashi Xie, Min-Jue Ikeda, Hiroshi Kuroda, Kazuki Komada, Munekazu Iguchi, Tokuichi Rahman, Mohammad Tariqur Morikubo, Soichi Noguchi, Koichi Murase, Kazuyuki Okabe, Masaru Sato, Makoto Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
description	Learning and memory depend on morphological and functional changes to neural spines. Non-muscle myosin 2b regulates actin dynamics downstream of long-term potentiation induction. However, the mechanism by which myosin 2b is regulated in the spine has not been fully elucidated. Here, we show that filamin A-interacting protein (FILIP) is involved in the control of neural spine morphology and is limitedly expressed in the brain. FILIP bound near the ATPase domain of non-muscle myosin heavy chain IIb, an essential component of myosin 2b, and modified the function of myosin 2b by interfering with its actin-binding activity. In addition, FILIP altered the subcellular distribution of myosin 2b in spines. Moreover, subunits of the NMDA receptor were differently distributed in FILIP-expressing neurons, and excitation propagation was altered in FILIP-knockout mice. These results indicate that FILIP is a novel, region-specific modulator of myosin 2b.
format	Article
author	Yagi, Hideshi Nagano, Takashi Xie, Min-Jue Ikeda, Hiroshi Kuroda, Kazuki Komada, Munekazu Iguchi, Tokuichi Rahman, Mohammad Tariqur Morikubo, Soichi Noguchi, Koichi Murase, Kazuyuki Okabe, Masaru Sato, Makoto
author_facet	Yagi, Hideshi Nagano, Takashi Xie, Min-Jue Ikeda, Hiroshi Kuroda, Kazuki Komada, Munekazu Iguchi, Tokuichi Rahman, Mohammad Tariqur Morikubo, Soichi Noguchi, Koichi Murase, Kazuyuki Okabe, Masaru Sato, Makoto
author_sort	Yagi, Hideshi
title	Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
title_short	Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
title_full	Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
title_fullStr	Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
title_full_unstemmed	Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
title_sort	filamin a-interacting protein (filip) is a region-specific modulator of myosin 2b and controls spine morphology and nmda receptor accumulation
publisher	Nature Publishing Group
publishDate	2014
url	http://irep.iium.edu.my/38350/ http://irep.iium.edu.my/38350/ http://irep.iium.edu.my/38350/1/Tariqur.pdf
first_indexed	2023-09-18T20:55:05Z
last_indexed	2023-09-18T20:55:05Z
_version_	1777410250617389056

Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation

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