Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review

Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review

Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) and PLGA-based polymeric nanoparticles are widely used for sustained release of protein and peptide drugs. These formulations are usually prepared by water/oil/water (W/O/W) and solid/oil/water (S/O/W) double emulsion solvent evaporation method....

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Main Authors: Ansary , Rezaul H., Awang, Mohamed Bin, Rahman, Md. Mokhlesur
Format: Article
Language:English
Published: Pharmacotherapy Group, Faculty of Pharmacy, University of Benin 2014
Subjects:
QD Chemistry
Online Access:http://irep.iium.edu.my/37845/
http://irep.iium.edu.my/37845/
http://irep.iium.edu.my/37845/1/Tropical_Journal_2014_%282014_13_7_24.pdf%29.pdf
id iium-37845
recordtype eprints
spelling iium-378452018-06-19T06:31:14Z http://irep.iium.edu.my/37845/ Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review Ansary , Rezaul H. Awang, Mohamed Bin Rahman, Md. Mokhlesur QD Chemistry Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) and PLGA-based polymeric nanoparticles are widely used for sustained release of protein and peptide drugs. These formulations are usually prepared by water/oil/water (W/O/W) and solid/oil/water (S/O/W) double emulsion solvent evaporation method. Other methods of preparation are nanoprecipitation, emulsion solvent diffusion and salting-out. This review attempts to address the effects of PLGA molecular weight, lactide to glycolide ratio, crystallinity, hydrophilicity as well as nanoparticles preparation variables (e.g., homogenizer speed, surfactants nature and concentration) on the size, morphology, drug encapsulation efficiency and release profile of PLGA mico/nanoparticles. The current knowledge of protein instability during preparation, storage and release from PLGA micro/nanoparticles and protein stabilization approaches has also been discussed in this review. Pharmacotherapy Group, Faculty of Pharmacy, University of Benin 2014-07-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/37845/1/Tropical_Journal_2014_%282014_13_7_24.pdf%29.pdf Ansary , Rezaul H. and Awang, Mohamed Bin and Rahman, Md. Mokhlesur (2014) Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review. Tropical Journal of Pharmaceutical Research, 13 (7). pp. 1179-1190. ISSN 1596-9827 (O), 1596-5996 (P) http://www.tjpr.org/vol13_no7/2014_13_7_24_download.html
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QD Chemistry
spellingShingle QD Chemistry
Ansary , Rezaul H.
Awang, Mohamed Bin
Rahman, Md. Mokhlesur
Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review
description Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) and PLGA-based polymeric nanoparticles are widely used for sustained release of protein and peptide drugs. These formulations are usually prepared by water/oil/water (W/O/W) and solid/oil/water (S/O/W) double emulsion solvent evaporation method. Other methods of preparation are nanoprecipitation, emulsion solvent diffusion and salting-out. This review attempts to address the effects of PLGA molecular weight, lactide to glycolide ratio, crystallinity, hydrophilicity as well as nanoparticles preparation variables (e.g., homogenizer speed, surfactants nature and concentration) on the size, morphology, drug encapsulation efficiency and release profile of PLGA mico/nanoparticles. The current knowledge of protein instability during preparation, storage and release from PLGA micro/nanoparticles and protein stabilization approaches has also been discussed in this review.
format Article
author Ansary , Rezaul H.
Awang, Mohamed Bin
Rahman, Md. Mokhlesur
author_facet Ansary , Rezaul H.
Awang, Mohamed Bin
Rahman, Md. Mokhlesur
author_sort Ansary , Rezaul H.
title Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review
title_short Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review
title_full Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review
title_fullStr Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review
title_full_unstemmed Biodegradable poly(D,L-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review
title_sort biodegradable poly(d,l-lactic-co-glycolic acid)-based micro/nanoparticles for sustained release of protein drugs - a review
publisher Pharmacotherapy Group, Faculty of Pharmacy, University of Benin
publishDate 2014
url http://irep.iium.edu.my/37845/
http://irep.iium.edu.my/37845/
http://irep.iium.edu.my/37845/1/Tropical_Journal_2014_%282014_13_7_24.pdf%29.pdf
first_indexed 2023-09-18T20:54:15Z
last_indexed 2023-09-18T20:54:15Z
_version_ 1777410198481141760

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