Investigation of the riddle of sulfathiazole polymorphism

Since the discovery of sulfathiazole as an antimicrobial agent in 1939, numerous works in the screening for its different polymorphic forms, which is an essential part of drug development, have been conducted and published. These works consequently result in the availability of various methods for...

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Main Authors:	Abu Bakar, Mohd Rushdi, Nagy, Zoltan K., Rielly, Chris D., Dann, Sandy E.
Format:	Article
Language:	English English
Published:	Elsevier 2011
Subjects:	RM Therapeutics. Pharmacology RM695 Physical medicine. Physical therapy
Online Access:	http://irep.iium.edu.my/377/ http://irep.iium.edu.my/377/ http://irep.iium.edu.my/377/ http://irep.iium.edu.my/377/1/Sulfathiazole_IJP.pdf http://irep.iium.edu.my/377/4/ijp_2011_rushdi.pdf

id	iium-377
recordtype	eprints
spelling	iium-3772014-06-04T17:29:14Z http://irep.iium.edu.my/377/ Investigation of the riddle of sulfathiazole polymorphism Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. Dann, Sandy E. RM Therapeutics. Pharmacology RM695 Physical medicine. Physical therapy Since the discovery of sulfathiazole as an antimicrobial agent in 1939, numerous works in the screening for its different polymorphic forms, which is an essential part of drug development, have been conducted and published. These works consequently result in the availability of various methods for generating a particular polymorph. By following these methods, however, one cannot be guaranteed to obtain the intended pure polymorph because most of the methods do not clearly and adequately describe the crystallization conditions, such as cooling rates and initial solute concentrations. In this paper, the available methods for generating all the known polymorphs of sulfathiazole are reviewed and selected methods for generating certain polymorphs, performed with their processes monitored using process analytical technology tools, i.e. focussed beam reflectance measurement and attenuated total reflectance ultraviolet spectroscopy, are presented. The properties of the obtained crystals, examined using various characterisation methods, are also presented and whenever possible, are compared with those of other workers. Elsevier 2011-05 Article PeerReviewed application/pdf en http://irep.iium.edu.my/377/1/Sulfathiazole_IJP.pdf application/pdf en http://irep.iium.edu.my/377/4/ijp_2011_rushdi.pdf Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. and Rielly, Chris D. and Dann, Sandy E. (2011) Investigation of the riddle of sulfathiazole polymorphism. International Journal of Pharmaceutics, 414. pp. 86-103. ISSN 0378-5173 http://dx.doi.org/10.1016/j.ijpharm.2011.05.004 doi:10.1016/j.ijpharm.2011.05.004
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RM Therapeutics. Pharmacology RM695 Physical medicine. Physical therapy
spellingShingle	RM Therapeutics. Pharmacology RM695 Physical medicine. Physical therapy Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. Dann, Sandy E. Investigation of the riddle of sulfathiazole polymorphism
description	Since the discovery of sulfathiazole as an antimicrobial agent in 1939, numerous works in the screening for its different polymorphic forms, which is an essential part of drug development, have been conducted and published. These works consequently result in the availability of various methods for generating a particular polymorph. By following these methods, however, one cannot be guaranteed to obtain the intended pure polymorph because most of the methods do not clearly and adequately describe the crystallization conditions, such as cooling rates and initial solute concentrations. In this paper, the available methods for generating all the known polymorphs of sulfathiazole are reviewed and selected methods for generating certain polymorphs, performed with their processes monitored using process analytical technology tools, i.e. focussed beam reflectance measurement and attenuated total reflectance ultraviolet spectroscopy, are presented. The properties of the obtained crystals, examined using various characterisation methods, are also presented and whenever possible, are compared with those of other workers.
format	Article
author	Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. Dann, Sandy E.
author_facet	Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. Dann, Sandy E.
author_sort	Abu Bakar, Mohd Rushdi
title	Investigation of the riddle of sulfathiazole polymorphism
title_short	Investigation of the riddle of sulfathiazole polymorphism
title_full	Investigation of the riddle of sulfathiazole polymorphism
title_fullStr	Investigation of the riddle of sulfathiazole polymorphism
title_full_unstemmed	Investigation of the riddle of sulfathiazole polymorphism
title_sort	investigation of the riddle of sulfathiazole polymorphism
publisher	Elsevier
publishDate	2011
url	http://irep.iium.edu.my/377/ http://irep.iium.edu.my/377/ http://irep.iium.edu.my/377/ http://irep.iium.edu.my/377/1/Sulfathiazole_IJP.pdf http://irep.iium.edu.my/377/4/ijp_2011_rushdi.pdf
first_indexed	2023-09-18T20:07:29Z
last_indexed	2023-09-18T20:07:29Z
_version_	1777407255992336384

Investigation of the riddle of sulfathiazole polymorphism

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