Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei

Context: Malaria is a mosquito‐borne disease caused by parasitic protozoa from the genus of Plasmodium. The protozoans have developed resistance against many of current drugs. It is urgent to find an alternative source of new antimalarial agent. In the effort to discover new antimalarial agents, thi...

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Main Authors:	Ramli, Norazsida, Syed Ahmad, Pakeer Oothuman, Sayed Ahmed, Hassan Mohamed Elhady, Bakhtiar, M. Taher
Format:	Article
Language:	English
Published:	Wolters Kluwer Health 2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/37609/ http://irep.iium.edu.my/37609/ http://irep.iium.edu.my/37609/ http://irep.iium.edu.my/37609/1/PhcogRes_2014_6_4_280_138248.pdf

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spelling	iium-376092016-12-28T07:34:56Z http://irep.iium.edu.my/37609/ Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Sayed Ahmed, Hassan Mohamed Elhady Bakhtiar, M. Taher RS Pharmacy and materia medica Context: Malaria is a mosquito‐borne disease caused by parasitic protozoa from the genus of Plasmodium. The protozoans have developed resistance against many of current drugs. It is urgent to find an alternative source of new antimalarial agent. In the effort to discover new antimalarial agents, this research has been conducted on Plectranthus amboinicus. Aims: This study was conducted to evaluate the toxicity and antiplasmodial properties of P. amboinicus. Materials and Methods: Acute oral toxicity dose at 5000 mg/kg was conducted to evaluate the safety of this extract. Twenty mice were divided into control and experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and histopathological changes. Antimalarial activity of different extract doses of 50, 200, 400 and 1000 mg/kg were tested in vivo against Plasmodium berghei infections in mice (five mice for each group) during early, established and residual infections. Results: The acute oral toxicity test revealed that no mortality or evidence of adverse effects was seen in the treated mice. The extract significantly reduced the parasitemia by the 50 (P = 0.000), 200 (P = 0.000) and 400 mg/kg doses (P = 0.000) in the in vivo prophylactic assay. The percentage chemo‐suppression was calculated as 83.33% for 50 mg/kg dose, 75.62% for 200 mg/kg dose and 90.74% for 400 mg/kg dose. Body weight of all treated groups; T1, T2, T3 and T4 also showed enhancement after 7 days posttreatment. Statistically no reduction of parasitemia calculated for curative and suppressive test. Conclusion: Thus, this extract may give a promising agent to be used as a prophylactic agent of P. berghei infection. Wolters Kluwer Health 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/37609/1/PhcogRes_2014_6_4_280_138248.pdf Ramli, Norazsida and Syed Ahmad, Pakeer Oothuman and Sayed Ahmed, Hassan Mohamed Elhady and Bakhtiar, M. Taher (2014) Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei. Pharmacognosy Research, 6 (4). pp. 280-284. ISSN 0976-4836 http://www.phcogres.com 10.4103/0974-8490.138248
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Sayed Ahmed, Hassan Mohamed Elhady Bakhtiar, M. Taher Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei
description	Context: Malaria is a mosquito‐borne disease caused by parasitic protozoa from the genus of Plasmodium. The protozoans have developed resistance against many of current drugs. It is urgent to find an alternative source of new antimalarial agent. In the effort to discover new antimalarial agents, this research has been conducted on Plectranthus amboinicus. Aims: This study was conducted to evaluate the toxicity and antiplasmodial properties of P. amboinicus. Materials and Methods: Acute oral toxicity dose at 5000 mg/kg was conducted to evaluate the safety of this extract. Twenty mice were divided into control and experimental group. All the mice were observed for signs of toxicity, mortality, weight changes and histopathological changes. Antimalarial activity of different extract doses of 50, 200, 400 and 1000 mg/kg were tested in vivo against Plasmodium berghei infections in mice (five mice for each group) during early, established and residual infections. Results: The acute oral toxicity test revealed that no mortality or evidence of adverse effects was seen in the treated mice. The extract significantly reduced the parasitemia by the 50 (P = 0.000), 200 (P = 0.000) and 400 mg/kg doses (P = 0.000) in the in vivo prophylactic assay. The percentage chemo‐suppression was calculated as 83.33% for 50 mg/kg dose, 75.62% for 200 mg/kg dose and 90.74% for 400 mg/kg dose. Body weight of all treated groups; T1, T2, T3 and T4 also showed enhancement after 7 days posttreatment. Statistically no reduction of parasitemia calculated for curative and suppressive test. Conclusion: Thus, this extract may give a promising agent to be used as a prophylactic agent of P. berghei infection.
format	Article
author	Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Sayed Ahmed, Hassan Mohamed Elhady Bakhtiar, M. Taher
author_facet	Ramli, Norazsida Syed Ahmad, Pakeer Oothuman Sayed Ahmed, Hassan Mohamed Elhady Bakhtiar, M. Taher
author_sort	Ramli, Norazsida
title	Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei
title_short	Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei
title_full	Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei
title_fullStr	Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei
title_full_unstemmed	Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei
title_sort	antimalarial activity of malaysian plectranthus amboinicus against plasmodium berghei
publisher	Wolters Kluwer Health
publishDate	2014
url	http://irep.iium.edu.my/37609/ http://irep.iium.edu.my/37609/ http://irep.iium.edu.my/37609/ http://irep.iium.edu.my/37609/1/PhcogRes_2014_6_4_280_138248.pdf
first_indexed	2023-09-18T20:53:56Z
last_indexed	2023-09-18T20:53:56Z
_version_	1777410178511011840

Antimalarial activity of Malaysian plectranthus amboinicus against plasmodium berghei

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