Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization

The effect of temperature cycling on the surface features of sulfathiazole crystals was investigated using focused beam reflectance measurement (FBRM) and ex situ optical microscopy, scanning electron microscopy (SEM), and atomic forced microscopy (AFM). Smoothing of the crystal surface was observ...

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Main Authors:	Abu Bakar, Mohd Rushdi, Nagy, Zoltan K., Rielly, Chris D.
Format:	Article
Language:	English
Published:	American Chemical Society 2010
Subjects:	QD Chemistry TP Chemical technology
Online Access:	http://irep.iium.edu.my/376/ http://irep.iium.edu.my/376/ http://irep.iium.edu.my/376/ http://irep.iium.edu.my/376/1/cgd_2010_rushdi.pdf

id	iium-376
recordtype	eprints
spelling	iium-3762011-12-19T23:58:01Z http://irep.iium.edu.my/376/ Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. QD Chemistry TP Chemical technology The effect of temperature cycling on the surface features of sulfathiazole crystals was investigated using focused beam reflectance measurement (FBRM) and ex situ optical microscopy, scanning electron microscopy (SEM), and atomic forced microscopy (AFM). Smoothing of the crystal surface was observed during heating, while during cooling the smooth crystals showed features growing on their surfaces. These changes on the crystal surface were detected by the FBRM as an increase in the number of coarse counts during heating phases and a drop during cooling phases. Laser beam spreading caused by the surface changes and signal/chord splitting due to the formation of sharp edges are suggested as explanations for the FBRM results. The study shows the capability of FBRM to provide useful information with regard to the changes on the surface of the crystalline products, which could be linked to possible growth mechanisms. The information can be used to avoid problems in the downstream processing or in the final product property due to variations in flowability and friability, which are related to the crystal surface property. American Chemical Society 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/376/1/cgd_2010_rushdi.pdf Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. and Rielly, Chris D. (2010) Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization. Crystal Growth & Design, 10 (9). pp. 3892-3900. ISSN 1528-7483 http://dx.doi.org/10.1021/cg1002379 doi:10.1021/cg1002379
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry TP Chemical technology
spellingShingle	QD Chemistry TP Chemical technology Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization
description	The effect of temperature cycling on the surface features of sulfathiazole crystals was investigated using focused beam reflectance measurement (FBRM) and ex situ optical microscopy, scanning electron microscopy (SEM), and atomic forced microscopy (AFM). Smoothing of the crystal surface was observed during heating, while during cooling the smooth crystals showed features growing on their surfaces. These changes on the crystal surface were detected by the FBRM as an increase in the number of coarse counts during heating phases and a drop during cooling phases. Laser beam spreading caused by the surface changes and signal/chord splitting due to the formation of sharp edges are suggested as explanations for the FBRM results. The study shows the capability of FBRM to provide useful information with regard to the changes on the surface of the crystalline products, which could be linked to possible growth mechanisms. The information can be used to avoid problems in the downstream processing or in the final product property due to variations in flowability and friability, which are related to the crystal surface property.
format	Article
author	Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D.
author_facet	Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D.
author_sort	Abu Bakar, Mohd Rushdi
title	Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization
title_short	Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization
title_full	Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization
title_fullStr	Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization
title_full_unstemmed	Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization
title_sort	investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization
publisher	American Chemical Society
publishDate	2010
url	http://irep.iium.edu.my/376/ http://irep.iium.edu.my/376/ http://irep.iium.edu.my/376/ http://irep.iium.edu.my/376/1/cgd_2010_rushdi.pdf
first_indexed	2023-09-18T20:07:29Z
last_indexed	2023-09-18T20:07:29Z
_version_	1777407255838195712

Investigation of the effect of temperature cycling on surface features of sulfathiazole crystals during seeded batch cooling crystallization

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