Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites

Biphasic calcium phosphate (BCP) has been used in tissue engineering and orthopedics due to its good biocompatibility and osteoconductivity. However, its clinical applications are usually limited by the low strength and brittleness. The objective of this research was to develop Zn-doped BCP composi...

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Main Authors:	-, Gunawan, Sopyan, Iis, Mel, Maizirwan, -, Suryanto
Format:	Article
Language:	English English
Published:	AENSI Publications 2014
Subjects:	TA164 Bioengineering
Online Access:	http://irep.iium.edu.my/37559/ http://irep.iium.edu.my/37559/ http://irep.iium.edu.my/37559/1/787-791.pdf http://irep.iium.edu.my/37559/4/37559_Preparation%20of%20zinc%20doped-biphasic_SCOPUS.pdf

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recordtype	eprints
spelling	iium-375592017-08-18T08:04:10Z http://irep.iium.edu.my/37559/ Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites -, Gunawan Sopyan, Iis Mel, Maizirwan -, Suryanto TA164 Bioengineering Biphasic calcium phosphate (BCP) has been used in tissue engineering and orthopedics due to its good biocompatibility and osteoconductivity. However, its clinical applications are usually limited by the low strength and brittleness. The objective of this research was to develop Zn-doped BCP composites in which multi-wall carbon nanotubes (MWCNT) were introduced to the Zn-doped BCP ceramic matrix to improve the mechanical properties of the resulting composites. The starting powders have been synthesized via sol-gel method. Zinc concentration was varied in the range of 0, 1, 2, 4, 5, and 10mol%. After uniaxial pressing the compacted samples were sintered via conventional pressureless sintering. The samples were studied in terms of the phase stability, relative density, Vickers hardness, and fracture toughness as well as in vitro analysis in SBF solution. The results showed that hydroxyapatite as the main phase and β-tricalcium phosphate as the secondary phase of obtained powders. The morphology of the powders show the formation of nanocrystalline powder and individual particles are globular in shape.The maximum micro Vickers hardness and fracture toughness was achieved when fired at 1200oC, with 4.30 GPa and 2.0 MPa.m1/2, respectively. In vitro analysis shows that the samples have been covered by apatite cell since day one, and the density of apatite increased with immersion time in SBF. This study showed that CNT reinforcing was beneficial in producing high toughness of BCP without offsetting its bioactivity properties. AENSI Publications 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/37559/1/787-791.pdf application/pdf en http://irep.iium.edu.my/37559/4/37559_Preparation%20of%20zinc%20doped-biphasic_SCOPUS.pdf -, Gunawan and Sopyan, Iis and Mel, Maizirwan and -, Suryanto (2014) Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites. Advances in Environmental Biology, 8 (3(Spe)). pp. 787-791. ISSN 1995-0756 E-ISSN 1998-1066 http://www.aensiweb.com/old/aeb/2014/787-791.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TA164 Bioengineering
spellingShingle	TA164 Bioengineering -, Gunawan Sopyan, Iis Mel, Maizirwan -, Suryanto Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites
description	Biphasic calcium phosphate (BCP) has been used in tissue engineering and orthopedics due to its good biocompatibility and osteoconductivity. However, its clinical applications are usually limited by the low strength and brittleness. The objective of this research was to develop Zn-doped BCP composites in which multi-wall carbon nanotubes (MWCNT) were introduced to the Zn-doped BCP ceramic matrix to improve the mechanical properties of the resulting composites. The starting powders have been synthesized via sol-gel method. Zinc concentration was varied in the range of 0, 1, 2, 4, 5, and 10mol%. After uniaxial pressing the compacted samples were sintered via conventional pressureless sintering. The samples were studied in terms of the phase stability, relative density, Vickers hardness, and fracture toughness as well as in vitro analysis in SBF solution. The results showed that hydroxyapatite as the main phase and β-tricalcium phosphate as the secondary phase of obtained powders. The morphology of the powders show the formation of nanocrystalline powder and individual particles are globular in shape.The maximum micro Vickers hardness and fracture toughness was achieved when fired at 1200oC, with 4.30 GPa and 2.0 MPa.m1/2, respectively. In vitro analysis shows that the samples have been covered by apatite cell since day one, and the density of apatite increased with immersion time in SBF. This study showed that CNT reinforcing was beneficial in producing high toughness of BCP without offsetting its bioactivity properties.
format	Article
author	-, Gunawan Sopyan, Iis Mel, Maizirwan -, Suryanto
author_facet	-, Gunawan Sopyan, Iis Mel, Maizirwan -, Suryanto
author_sort	-, Gunawan
title	Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites
title_short	Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites
title_full	Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites
title_fullStr	Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites
title_full_unstemmed	Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites
title_sort	preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites
publisher	AENSI Publications
publishDate	2014
url	http://irep.iium.edu.my/37559/ http://irep.iium.edu.my/37559/ http://irep.iium.edu.my/37559/1/787-791.pdf http://irep.iium.edu.my/37559/4/37559_Preparation%20of%20zinc%20doped-biphasic_SCOPUS.pdf
first_indexed	2023-09-18T20:53:53Z
last_indexed	2023-09-18T20:53:53Z
_version_	1777410175209046016

Preparation of zinc doped-biphasic calcium phosphate/carbon nanotube composites

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