A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

A combination of differential scanning calorimetry and hot-stage microscopy with image analysis has been used to investigate the polymorphism of sulfathiazole. The use of light intensity profiles obtained from the HSM images, as an alternative way to present results of the HSM analysis, was found to...

Full description

Bibliographic Details
Main Authors:	Abu Bakar, Mohd Rushdi, Nagy, Zoltan K., Rielly, Chris D.
Format:	Article
Language:	English
Published:	Springer 2010
Subjects:	QD Chemistry TP Chemical technology
Online Access:	http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/1/jtac_2010_rushdi.pdf

id	iium-375
recordtype	eprints
spelling	iium-3752011-07-11T04:33:04Z http://irep.iium.edu.my/375/ A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. QD Chemistry TP Chemical technology A combination of differential scanning calorimetry and hot-stage microscopy with image analysis has been used to investigate the polymorphism of sulfathiazole. The use of light intensity profiles obtained from the HSM images, as an alternative way to present results of the HSM analysis, was found to be useful in describing and verifying thermal events. The approach provides a unique insight into the polymorphic transformations and thermal behaviour exhibited by this compound. The results of the experiments show that sulfathiazole tends to crystallise as mixtures of polymorphs, even though the literature methods for producing pure polymorph were followed. Springer 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/375/1/jtac_2010_rushdi.pdf Abu Bakar, Mohd Rushdi and Nagy, Zoltan K. and Rielly, Chris D. (2010) A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism. Journal of Thermal Analysis and Calorimetry, 99 (2). pp. 609-619. ISSN 1388-6150 http://www.springerlink.com/content/b2h7611258473620/ doi:10.1007/s10973-009-0001-z
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry TP Chemical technology
spellingShingle	QD Chemistry TP Chemical technology Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D. A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
description	A combination of differential scanning calorimetry and hot-stage microscopy with image analysis has been used to investigate the polymorphism of sulfathiazole. The use of light intensity profiles obtained from the HSM images, as an alternative way to present results of the HSM analysis, was found to be useful in describing and verifying thermal events. The approach provides a unique insight into the polymorphic transformations and thermal behaviour exhibited by this compound. The results of the experiments show that sulfathiazole tends to crystallise as mixtures of polymorphs, even though the literature methods for producing pure polymorph were followed.
format	Article
author	Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D.
author_facet	Abu Bakar, Mohd Rushdi Nagy, Zoltan K. Rielly, Chris D.
author_sort	Abu Bakar, Mohd Rushdi
title	A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
title_short	A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
title_full	A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
title_fullStr	A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
title_full_unstemmed	A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
title_sort	combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism
publisher	Springer
publishDate	2010
url	http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/ http://irep.iium.edu.my/375/1/jtac_2010_rushdi.pdf
first_indexed	2023-09-18T20:07:29Z
last_indexed	2023-09-18T20:07:29Z
_version_	1777407255690346496

A combined approach of differential scanning calorimetry and hot-stage microscopy with image analysis in the investigation of sulfathiazole polymorphism

Similar Items