Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats

Introduction: Nigella sativa seeds “black cumin” have been widely used in traditional medicine for diseases treatment including hypertension. Thymoquinone (TQ) is one of the major active constituents in its volatile oil. Objectives: The objective of the current study was to confirm the blood pressu...

Full description

Bibliographic Details
Main Authors:	Azzubaidi, Marwan Saad, Mizher, Hussam A., Noor, Noriah Mohd
Format:	Conference or Workshop Item
Language:	English
Published:	2014
Subjects:	R Medicine (General) RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/37006/ http://irep.iium.edu.my/37006/ http://irep.iium.edu.my/37006/1/AFCC_Oral_Presentation_Abstract_2014.pdf

id	iium-37006
recordtype	eprints
spelling	iium-370062014-06-25T01:25:37Z http://irep.iium.edu.my/37006/ Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats Azzubaidi, Marwan Saad Mizher, Hussam A. Noor, Noriah Mohd R Medicine (General) RM300 Drugs and their action Introduction: Nigella sativa seeds “black cumin” have been widely used in traditional medicine for diseases treatment including hypertension. Thymoquinone (TQ) is one of the major active constituents in its volatile oil. Objectives: The objective of the current study was to confirm the blood pressure lowering effect of TQ, and to investigate its mechanism through muscarinic and β adrenergic receptors. Methods: Mean arterial blood pressure (MAP) was recorded using the non-invasive blood pressure tail cuff technique. Dose-response relationship was obtained after using 3 TQ doses (2.5, 5 and 10 mg/kg) intraperitoneally to 3 different groups (n=5) of adult male Sprague Dawley rats under pentobarbital anesthesia. MAP was then measured for other 2 animal groups pretreated either with atropine (P-at) or propranolol (P-pro) followed by 10mg/kg TQ. Results: TQ produced a dose-dependent blood pressure lowering effect, where 2.5 mg/kg reduced MAP by 8±1 mmHg, whereas 5 and 10 mg/kg of TQ treatment decreased MAP by 12±3 and 29±3 mmHg, respectively. TQ-induced MAP reduction was significantly less in P-at than non-pretreated group. Conversely, TQ-induced MAP reduction in P-pro did not demonstrate significant difference from the non-pretreated group. Conclusion: This study confirms the dose-related hypotensive effect of TQ and provides an evidence for the traditional use of Nigella sativa for treatment of hypertension. The mechanism of TQ-induced hypotension involves at least in part activation of vascular muscarinic receptors, but not β-adrenergic receptors. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/37006/1/AFCC_Oral_Presentation_Abstract_2014.pdf Azzubaidi, Marwan Saad and Mizher, Hussam A. and Noor, Noriah Mohd (2014) Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats. In: 20th ASEAN Federation of Cardiology Congress 2014, 12th-15th June 2014, Kuala Lumpur Convention Centre. http://www.nham-conference.com/?event=3&cmd=home
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General) RM300 Drugs and their action
spellingShingle	R Medicine (General) RM300 Drugs and their action Azzubaidi, Marwan Saad Mizher, Hussam A. Noor, Noriah Mohd Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats
description	Introduction: Nigella sativa seeds “black cumin” have been widely used in traditional medicine for diseases treatment including hypertension. Thymoquinone (TQ) is one of the major active constituents in its volatile oil. Objectives: The objective of the current study was to confirm the blood pressure lowering effect of TQ, and to investigate its mechanism through muscarinic and β adrenergic receptors. Methods: Mean arterial blood pressure (MAP) was recorded using the non-invasive blood pressure tail cuff technique. Dose-response relationship was obtained after using 3 TQ doses (2.5, 5 and 10 mg/kg) intraperitoneally to 3 different groups (n=5) of adult male Sprague Dawley rats under pentobarbital anesthesia. MAP was then measured for other 2 animal groups pretreated either with atropine (P-at) or propranolol (P-pro) followed by 10mg/kg TQ. Results: TQ produced a dose-dependent blood pressure lowering effect, where 2.5 mg/kg reduced MAP by 8±1 mmHg, whereas 5 and 10 mg/kg of TQ treatment decreased MAP by 12±3 and 29±3 mmHg, respectively. TQ-induced MAP reduction was significantly less in P-at than non-pretreated group. Conversely, TQ-induced MAP reduction in P-pro did not demonstrate significant difference from the non-pretreated group. Conclusion: This study confirms the dose-related hypotensive effect of TQ and provides an evidence for the traditional use of Nigella sativa for treatment of hypertension. The mechanism of TQ-induced hypotension involves at least in part activation of vascular muscarinic receptors, but not β-adrenergic receptors.
format	Conference or Workshop Item
author	Azzubaidi, Marwan Saad Mizher, Hussam A. Noor, Noriah Mohd
author_facet	Azzubaidi, Marwan Saad Mizher, Hussam A. Noor, Noriah Mohd
author_sort	Azzubaidi, Marwan Saad
title	Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats
title_short	Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats
title_full	Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats
title_fullStr	Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats
title_full_unstemmed	Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats
title_sort	hypotensive receptor mechanisms of thymoquinone-treated ormotensive rats
publishDate	2014
url	http://irep.iium.edu.my/37006/ http://irep.iium.edu.my/37006/ http://irep.iium.edu.my/37006/1/AFCC_Oral_Presentation_Abstract_2014.pdf
first_indexed	2023-09-18T20:53:04Z
last_indexed	2023-09-18T20:53:04Z
_version_	1777410123998691328

Hypotensive receptor mechanisms of Thymoquinone-treated ormotensive rats

Similar Items