Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement

Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement

The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH)2, and diammonium hydrogen phosphate, (NH4)2HPO4, have b...

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Main Authors: Hablee, Sufiamie, Sopyan, Iis, Mel, Maizirwan, Mohd. Salleh, Hamzah, Rahman, Mujibur
Format: Article
Language:English
English
English
Published: Kulliyyah of Engineering, International Islamic University Malaysia 2018
Subjects:
TJ Mechanical engineering and machinery
TP248.13 Biotechnology
Online Access:http://irep.iium.edu.my/3677/
http://irep.iium.edu.my/3677/
http://irep.iium.edu.my/3677/
http://irep.iium.edu.my/3677/1/3677_Effect%20of%20poly%28ethylene%20glycol%29%20on%20the%20injectability.pdf
http://irep.iium.edu.my/3677/7/3677%20EFFECT%20OF%20POLY%20%28ETHYLENE%20GLYCOL%29%20ON%20THE%20INJECTABILITY%20SCOPUS.pdf
http://irep.iium.edu.my/3677/8/3677%20EFFECT%20OF%20POLY%20%28ETHYLENE%20GLYCOL%29%20ON%20THE%20INJECTABILITY%20WOS.pdf
id iium-3677
recordtype eprints
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
English
English
topic TJ Mechanical engineering and machinery
TP248.13 Biotechnology
spellingShingle TJ Mechanical engineering and machinery
TP248.13 Biotechnology
Hablee, Sufiamie
Sopyan, Iis
Mel, Maizirwan
Mohd. Salleh, Hamzah
Rahman, Mujibur
Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement
description The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH)2, and diammonium hydrogen phosphate, (NH4)2HPO4, have been used as precursors in wet chemical precipitation synthesis of hydroxyapatite powder. Cement paste was prepared with different powder-to-liquid ratios, varied at 1.0, 1.3, 1.5 and 2.0. The incorporation of PEG was also varied at 1, 2, 3, 4 and 5 wt% at the powder-to-liquid ratio of 1.3. The CPC produced was then evaluated in terms of injectability, setting time and mechanical strength. The results indicated that PEG addition significantly improved setting time, injectability, as well as compressive strength of CPC. Without PEG, the initial setting time ranged between 3 and 122 min, while the final setting time ranged between 5 and 277 min. The addition of PEG has significantly improved setting time where the initial setting time ranged from 47 to 88 min and the final setting time ranged from 182 to 228 min. The extrusion load decreased when PEG was added, which revealed an improvement in injectability; 82.5% without PEG addition and 95.5% when 5% PEG was added. The compressive strength of CPC is in the range of 0.59 to 1.344 MPa and its porosity is in the range of 39.2% to 47.1%. With the incorporation of PEG, the compressive strength greatly increased to the range of 1.167 and 1.786 MPa. ******************************************************** Penyelidikan ini melaporkan tentang kesan menambah polietilina glikol (PEG) terhadap sifat-sifat simen kalsium fosfat seperti keupayaan suntikan, masa pengerasan dan kekuatan mekanikal. Kalsium hidroksida dan diammonium hidrogen fosfat digunakan sebagai reagen dalam kaedah pemendakan kimia basah bagi menghasilkan serbuk hidroksiapatit. Pes simen disediakan dengan nisbah serbuk kepada cecair yang berbeza, dengan nisbah 1.0, 1.3, 1.5 dan 2.0. Kemudian, PEG ditambah ke dalam simen kalsium fosfat dengan kepekatan yang berbeza, bernilai 1, 2, 3, 4 dan 5 wt% bagi 1.3 nisbah serbuk kepada cecair. Simen yang terhasil diuji bagi menilai keupayaan suntikan, masa pengerasan dan kekuatan mekanikal. Keputusan ujian-ujian tersebut menunjukkan bahawa penambahan PEG ke dalam simen telah meningkatkan kebolehan simen untuk disuntik, mengurangkan masa pengerasan simen dan meningkatkan kekuatan mekanikal simen. Simen tanpa PEG mempunyai masa pengerasan awal daripada 3 min kepada 122 min dan masa pengerasan akhir daripada 5 min kepada 277 min. Apabila PEG ditambah, masa pengerasan simen menjadi lebih baik dengan masa pengerasan awal daripada 47 min kepada 88 min dan masa pengerasan akhir daripada 182 min kepada 228 min. Peningkatan dalam keupayaan simen untuk disuntik telah dibuktikan dengan pengurangan beban penyempitan apabila PEG ditambah ke dalam simen. Simen tanpa PEG mempunyai 82.5% keupayaan suntikan dan meningkat kepada 95.5% apabila 5% PEG ditambah. Kekuatan mampatan simen bernilai antara 0.59 dan 1.334 MPa dan keliangan simen bernilai antara 39.2% dan 47.1%. Kekuatan mampatan simen meningkat dengan ketara apabila PEG ditambah, bernilai antara 1.167 dan 1.786 Mpa.
format Article
author Hablee, Sufiamie
Sopyan, Iis
Mel, Maizirwan
Mohd. Salleh, Hamzah
Rahman, Mujibur
author_facet Hablee, Sufiamie
Sopyan, Iis
Mel, Maizirwan
Mohd. Salleh, Hamzah
Rahman, Mujibur
author_sort Hablee, Sufiamie
title Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement
title_short Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement
title_full Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement
title_fullStr Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement
title_full_unstemmed Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement
title_sort effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement
publisher Kulliyyah of Engineering, International Islamic University Malaysia
publishDate 2018
url http://irep.iium.edu.my/3677/
http://irep.iium.edu.my/3677/
http://irep.iium.edu.my/3677/
http://irep.iium.edu.my/3677/1/3677_Effect%20of%20poly%28ethylene%20glycol%29%20on%20the%20injectability.pdf
http://irep.iium.edu.my/3677/7/3677%20EFFECT%20OF%20POLY%20%28ETHYLENE%20GLYCOL%29%20ON%20THE%20INJECTABILITY%20SCOPUS.pdf
http://irep.iium.edu.my/3677/8/3677%20EFFECT%20OF%20POLY%20%28ETHYLENE%20GLYCOL%29%20ON%20THE%20INJECTABILITY%20WOS.pdf
first_indexed 2023-09-18T20:11:35Z
last_indexed 2023-09-18T20:11:35Z
_version_ 1777407513966149632
spelling iium-36772019-01-27T07:52:13Z http://irep.iium.edu.my/3677/ Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement Hablee, Sufiamie Sopyan, Iis Mel, Maizirwan Mohd. Salleh, Hamzah Rahman, Mujibur TJ Mechanical engineering and machinery TP248.13 Biotechnology The present paper reports on the effect of poly(ethylene glycol) (PEG) addition on injectability, setting behaviour, and mechanical properties of calcium phosphate cement (CPC) for injectable bone filling applications. Calcium hydroxide, Ca(OH)2, and diammonium hydrogen phosphate, (NH4)2HPO4, have been used as precursors in wet chemical precipitation synthesis of hydroxyapatite powder. Cement paste was prepared with different powder-to-liquid ratios, varied at 1.0, 1.3, 1.5 and 2.0. The incorporation of PEG was also varied at 1, 2, 3, 4 and 5 wt% at the powder-to-liquid ratio of 1.3. The CPC produced was then evaluated in terms of injectability, setting time and mechanical strength. The results indicated that PEG addition significantly improved setting time, injectability, as well as compressive strength of CPC. Without PEG, the initial setting time ranged between 3 and 122 min, while the final setting time ranged between 5 and 277 min. The addition of PEG has significantly improved setting time where the initial setting time ranged from 47 to 88 min and the final setting time ranged from 182 to 228 min. The extrusion load decreased when PEG was added, which revealed an improvement in injectability; 82.5% without PEG addition and 95.5% when 5% PEG was added. The compressive strength of CPC is in the range of 0.59 to 1.344 MPa and its porosity is in the range of 39.2% to 47.1%. With the incorporation of PEG, the compressive strength greatly increased to the range of 1.167 and 1.786 MPa. ******************************************************** Penyelidikan ini melaporkan tentang kesan menambah polietilina glikol (PEG) terhadap sifat-sifat simen kalsium fosfat seperti keupayaan suntikan, masa pengerasan dan kekuatan mekanikal. Kalsium hidroksida dan diammonium hidrogen fosfat digunakan sebagai reagen dalam kaedah pemendakan kimia basah bagi menghasilkan serbuk hidroksiapatit. Pes simen disediakan dengan nisbah serbuk kepada cecair yang berbeza, dengan nisbah 1.0, 1.3, 1.5 dan 2.0. Kemudian, PEG ditambah ke dalam simen kalsium fosfat dengan kepekatan yang berbeza, bernilai 1, 2, 3, 4 dan 5 wt% bagi 1.3 nisbah serbuk kepada cecair. Simen yang terhasil diuji bagi menilai keupayaan suntikan, masa pengerasan dan kekuatan mekanikal. Keputusan ujian-ujian tersebut menunjukkan bahawa penambahan PEG ke dalam simen telah meningkatkan kebolehan simen untuk disuntik, mengurangkan masa pengerasan simen dan meningkatkan kekuatan mekanikal simen. Simen tanpa PEG mempunyai masa pengerasan awal daripada 3 min kepada 122 min dan masa pengerasan akhir daripada 5 min kepada 277 min. Apabila PEG ditambah, masa pengerasan simen menjadi lebih baik dengan masa pengerasan awal daripada 47 min kepada 88 min dan masa pengerasan akhir daripada 182 min kepada 228 min. Peningkatan dalam keupayaan simen untuk disuntik telah dibuktikan dengan pengurangan beban penyempitan apabila PEG ditambah ke dalam simen. Simen tanpa PEG mempunyai 82.5% keupayaan suntikan dan meningkat kepada 95.5% apabila 5% PEG ditambah. Kekuatan mampatan simen bernilai antara 0.59 dan 1.334 MPa dan keliangan simen bernilai antara 39.2% dan 47.1%. Kekuatan mampatan simen meningkat dengan ketara apabila PEG ditambah, bernilai antara 1.167 dan 1.786 Mpa. Kulliyyah of Engineering, International Islamic University Malaysia 2018-12-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/3677/1/3677_Effect%20of%20poly%28ethylene%20glycol%29%20on%20the%20injectability.pdf application/pdf en http://irep.iium.edu.my/3677/7/3677%20EFFECT%20OF%20POLY%20%28ETHYLENE%20GLYCOL%29%20ON%20THE%20INJECTABILITY%20SCOPUS.pdf application/pdf en http://irep.iium.edu.my/3677/8/3677%20EFFECT%20OF%20POLY%20%28ETHYLENE%20GLYCOL%29%20ON%20THE%20INJECTABILITY%20WOS.pdf Hablee, Sufiamie and Sopyan, Iis and Mel, Maizirwan and Mohd. Salleh, Hamzah and Rahman, Mujibur (2018) Effect of poly(ethylene glycol) on the injectability, setting behavior and mechanical properties of calcium phosphate bone cement. IIUM Engineering Journal, 19 (2). pp. 192-202. ISSN 1511-788X E-ISSN 2289-7860 http://journals.iium.edu.my/ejournal/index.php/iiumej/article/view/913 10.31436/iiumej.v19i2.913

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