Anemia in Malaysian women with rheumatoid arthritis

Aim: To determine the prevalence of anaemia among women with rheumatoid arthritis (RA) and determine its association between disease activity and disease modifying anti-rheumatic drugs (DMARDs)in a two-centre study between National University Malaysia Medical Centre and Putrajaya Hospital. Method...

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Main Authors:	Hussein, Heselyn, Othman, AZ, Shahar, Mohammad Arif
Format:	Article
Language:	English English
Published:	Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd 2014
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://irep.iium.edu.my/36731/ http://irep.iium.edu.my/36731/1/Anemia_in_Malaysian_Women_with_Rheumatoid_Arthritis.pdf http://irep.iium.edu.my/36731/6/aplar0298.pdf

id	iium-36731
recordtype	eprints
spelling	iium-367312014-07-01T07:31:09Z http://irep.iium.edu.my/36731/ Anemia in Malaysian women with rheumatoid arthritis Hussein, Heselyn Othman, AZ Shahar, Mohammad Arif R Medicine (General) RC Internal medicine Aim: To determine the prevalence of anaemia among women with rheumatoid arthritis (RA) and determine its association between disease activity and disease modifying anti-rheumatic drugs (DMARDs)in a two-centre study between National University Malaysia Medical Centre and Putrajaya Hospital. Methods: This was a cross-sectional study involving female patients with established RA. Those with and without anaemia were compared in terms of RA disease activity and DMARDs received. Results: Sixty-two women with established RA were analysed. The prevalence of anaemia in our centres was 25.8%. Majority of patients have mild anaemia and none had severe anaemia. Patients with moderate and severe disease activity have a significantly higher prevalence of anaemia compared to those in remission and low disease activity (p = 0.026). Pre-menopausal women comprise two-thirds of the study population (67.7%) and 32.3% were postmenopausal women. The Hb levels between these two groups were statistically non-significant (Hb 12.37 +/- 1.05 versus 12.50 +/- 0.91 g/dL respectively with a P-value of 0.640). Majority of DMARDs do not have any association with anemia except for those on anti-TNF who had a higher prevalence of anemia (P-value of 0.039). Conclusion: There was a significant association between anaemia and disease activity with more significant anaemia in active disease compared to those in remission. Menstrual history did not have any association with anaemia. There was no association of DMARDs with anaemia except for anti-TNF. Although anti-TNF has been shown to significantly improve Hb levels in RA patients, in our study those on anti-TNF were more likely to have anaemia. This was because they had more active disease and more severe anaemia due to the disease, rather than anti-TNF alpha causing anaemia. Patients with anaemia have more active diseaes and anaemia will likely respond if the disease is controlled. Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/36731/1/Anemia_in_Malaysian_Women_with_Rheumatoid_Arthritis.pdf application/pdf en http://irep.iium.edu.my/36731/6/aplar0298.pdf Hussein, Heselyn and Othman, AZ and Shahar, Mohammad Arif (2014) Anemia in Malaysian women with rheumatoid arthritis. International Journal of Rheumatic Diseases, 17 (Supp 1). p. 54. ISSN 1756-185X
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Hussein, Heselyn Othman, AZ Shahar, Mohammad Arif Anemia in Malaysian women with rheumatoid arthritis
description	Aim: To determine the prevalence of anaemia among women with rheumatoid arthritis (RA) and determine its association between disease activity and disease modifying anti-rheumatic drugs (DMARDs)in a two-centre study between National University Malaysia Medical Centre and Putrajaya Hospital. Methods: This was a cross-sectional study involving female patients with established RA. Those with and without anaemia were compared in terms of RA disease activity and DMARDs received. Results: Sixty-two women with established RA were analysed. The prevalence of anaemia in our centres was 25.8%. Majority of patients have mild anaemia and none had severe anaemia. Patients with moderate and severe disease activity have a significantly higher prevalence of anaemia compared to those in remission and low disease activity (p = 0.026). Pre-menopausal women comprise two-thirds of the study population (67.7%) and 32.3% were postmenopausal women. The Hb levels between these two groups were statistically non-significant (Hb 12.37 +/- 1.05 versus 12.50 +/- 0.91 g/dL respectively with a P-value of 0.640). Majority of DMARDs do not have any association with anemia except for those on anti-TNF who had a higher prevalence of anemia (P-value of 0.039). Conclusion: There was a significant association between anaemia and disease activity with more significant anaemia in active disease compared to those in remission. Menstrual history did not have any association with anaemia. There was no association of DMARDs with anaemia except for anti-TNF. Although anti-TNF has been shown to significantly improve Hb levels in RA patients, in our study those on anti-TNF were more likely to have anaemia. This was because they had more active disease and more severe anaemia due to the disease, rather than anti-TNF alpha causing anaemia. Patients with anaemia have more active diseaes and anaemia will likely respond if the disease is controlled.
format	Article
author	Hussein, Heselyn Othman, AZ Shahar, Mohammad Arif
author_facet	Hussein, Heselyn Othman, AZ Shahar, Mohammad Arif
author_sort	Hussein, Heselyn
title	Anemia in Malaysian women with rheumatoid arthritis
title_short	Anemia in Malaysian women with rheumatoid arthritis
title_full	Anemia in Malaysian women with rheumatoid arthritis
title_fullStr	Anemia in Malaysian women with rheumatoid arthritis
title_full_unstemmed	Anemia in Malaysian women with rheumatoid arthritis
title_sort	anemia in malaysian women with rheumatoid arthritis
publisher	Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd
publishDate	2014
url	http://irep.iium.edu.my/36731/ http://irep.iium.edu.my/36731/1/Anemia_in_Malaysian_Women_with_Rheumatoid_Arthritis.pdf http://irep.iium.edu.my/36731/6/aplar0298.pdf
first_indexed	2023-09-18T20:52:40Z
last_indexed	2023-09-18T20:52:40Z
_version_	1777410098055872512

Anemia in Malaysian women with rheumatoid arthritis

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