Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats

Nigella sativa (NS), more commonly known as ‘’Habbattu Sauda’’, is a plant that is traditionally used to control hypertension. Evidence based studies revealed that NS exerts diuretic and blood pressure lowering effect in spontaneously hypertensive rat. While the volatile oil of NS acts centrally by...

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Main Authors:	Mizher, Hussam A., Noor, Noriah Mohd, Azzubaidi, Marwan Saad
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2014
Subjects:	QP Physiology R Medicine (General) RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/36627/ http://irep.iium.edu.my/36627/ http://irep.iium.edu.my/36627/1/Conf._NATPRO-5_2014.pdf http://irep.iium.edu.my/36627/3/nutrient_topics_-_1.pdf http://irep.iium.edu.my/36627/4/Poster_Session_number.pdf http://irep.iium.edu.my/36627/6/Program_at_a_glance12.pdf

id	iium-36627
recordtype	eprints
spelling	iium-366272014-05-15T01:54:17Z http://irep.iium.edu.my/36627/ Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats Mizher, Hussam A. Noor, Noriah Mohd Azzubaidi, Marwan Saad QP Physiology R Medicine (General) RM300 Drugs and their action RS Pharmacy and materia medica Nigella sativa (NS), more commonly known as ‘’Habbattu Sauda’’, is a plant that is traditionally used to control hypertension. Evidence based studies revealed that NS exerts diuretic and blood pressure lowering effect in spontaneously hypertensive rat. While the volatile oil of NS acts centrally by indirect and direct mechanisms to induce cardio-depressant effect in urethane-anaesthetized rats, Thymoquinone (TQ) represents the main active constituent in the volatile oil, which could be the principal substance of the direct mechanism. Objective was to evaluate the hypotensive effect of TQ and its dose-response relationship in normotensive adult rats using the non-invasive tail-cuff technique. To investigate TQ mechanism of action through muscarinic and β adrenergic receptors. Three doses of TQ (2.5, 5 and 10 mg\kg) were used for assessing TQ hypotensive effect in 3 groups of rats (n=5) under sodium pentobarbital anesthesia. TQ was administered intraperitoneally, and mean arterial blood pressure (MAP) was obtained from recording systolic and diastolic pressure readings using the non-invasive tail-cuff technique and the dose-response relationship was obtained. MAP was then measured for other 2 animal groups pretreated either with atropine (P-at) or propranolol (P-pro) followed by 10 mg/kg TQ. This study confirms the dose-related hypotensive effect of TQ. The study showed that the mechanism of TQ-induced hypotension involves at least stimulation of vascular muscarinic receptors, but not β-adrenergic receptors. This study provides an evidence for the traditional use of Nigella sativa for treatment of hypertension. 2014 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/36627/1/Conf._NATPRO-5_2014.pdf application/pdf en http://irep.iium.edu.my/36627/3/nutrient_topics_-_1.pdf application/pdf en http://irep.iium.edu.my/36627/4/Poster_Session_number.pdf application/pdf en http://irep.iium.edu.my/36627/6/Program_at_a_glance12.pdf Mizher, Hussam A. and Noor, Noriah Mohd and Azzubaidi, Marwan Saad (2014) Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats. In: The 5th International Conference on Natural Products for Health and Beauty (NATPRO 5), May 6-8, 2014, Moevenpick Resort & Spa Karon Beach Phuket, Thailand. (Unpublished) http://www.natpro5.psu.ac.th/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	QP Physiology R Medicine (General) RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	QP Physiology R Medicine (General) RM300 Drugs and their action RS Pharmacy and materia medica Mizher, Hussam A. Noor, Noriah Mohd Azzubaidi, Marwan Saad Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
description	Nigella sativa (NS), more commonly known as ‘’Habbattu Sauda’’, is a plant that is traditionally used to control hypertension. Evidence based studies revealed that NS exerts diuretic and blood pressure lowering effect in spontaneously hypertensive rat. While the volatile oil of NS acts centrally by indirect and direct mechanisms to induce cardio-depressant effect in urethane-anaesthetized rats, Thymoquinone (TQ) represents the main active constituent in the volatile oil, which could be the principal substance of the direct mechanism. Objective was to evaluate the hypotensive effect of TQ and its dose-response relationship in normotensive adult rats using the non-invasive tail-cuff technique. To investigate TQ mechanism of action through muscarinic and β adrenergic receptors. Three doses of TQ (2.5, 5 and 10 mg\kg) were used for assessing TQ hypotensive effect in 3 groups of rats (n=5) under sodium pentobarbital anesthesia. TQ was administered intraperitoneally, and mean arterial blood pressure (MAP) was obtained from recording systolic and diastolic pressure readings using the non-invasive tail-cuff technique and the dose-response relationship was obtained. MAP was then measured for other 2 animal groups pretreated either with atropine (P-at) or propranolol (P-pro) followed by 10 mg/kg TQ. This study confirms the dose-related hypotensive effect of TQ. The study showed that the mechanism of TQ-induced hypotension involves at least stimulation of vascular muscarinic receptors, but not β-adrenergic receptors. This study provides an evidence for the traditional use of Nigella sativa for treatment of hypertension.
format	Conference or Workshop Item
author	Mizher, Hussam A. Noor, Noriah Mohd Azzubaidi, Marwan Saad
author_facet	Mizher, Hussam A. Noor, Noriah Mohd Azzubaidi, Marwan Saad
author_sort	Mizher, Hussam A.
title	Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_short	Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_full	Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_fullStr	Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_full_unstemmed	Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
title_sort	receptor mechanisms of thymoquinone-induced hypotension in normotensive rats
publishDate	2014
url	http://irep.iium.edu.my/36627/ http://irep.iium.edu.my/36627/ http://irep.iium.edu.my/36627/1/Conf._NATPRO-5_2014.pdf http://irep.iium.edu.my/36627/3/nutrient_topics_-_1.pdf http://irep.iium.edu.my/36627/4/Poster_Session_number.pdf http://irep.iium.edu.my/36627/6/Program_at_a_glance12.pdf
first_indexed	2023-09-18T20:52:28Z
last_indexed	2023-09-18T20:52:28Z
_version_	1777410085547409408

Receptor mechanisms of thymoquinone-induced hypotension in normotensive rats

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