Serum cancer antigen 125 in patients with pleural effusions

We studied the prevalence of raised serum CA125 in patients with pleural effusions and explored factors affecting its level. Sixty four patients with benign effusions and 36 patients with malignant effusions admitted to the University Malaya Medical Centre from May 2001 to January 2002 were included...

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Main Authors:	How, Soon Hin, Liam, C K, Ab Rahman, Jamalludin, Chin, S P, Zal, A. B.
Format:	Article
Language:	English
Published:	Malaysian Medical Association 2006
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/3662/ http://irep.iium.edu.my/3662/ http://irep.iium.edu.my/3662/1/Serum_Cancer_Antigen_125.pdf

id	iium-3662
recordtype	eprints
spelling	iium-36622016-03-10T06:49:38Z http://irep.iium.edu.my/3662/ Serum cancer antigen 125 in patients with pleural effusions How, Soon Hin Liam, C K Ab Rahman, Jamalludin Chin, S P Zal, A. B. R Medicine (General) We studied the prevalence of raised serum CA125 in patients with pleural effusions and explored factors affecting its level. Sixty four patients with benign effusions and 36 patients with malignant effusions admitted to the University Malaya Medical Centre from May 2001 to January 2002 were included in the study. There were no significant differences in age, gender and ethnicity of the patients with benign and malignant effusions. There was also no difference in the frequency of the side of pleural effusion between the two groups but compared to benign effusions, a higher proportion of malignant effusions was moderate to large in size (66% versus 39%, p = 0.011). Serum CA125 levels were above 35U/dL in 83.3% and 78.1% of patients with malignant and benign effusions, respectively (p = 0.532). All patients with underlying malignancy and 95.3% of patients with benign effusions had pleural fluid CA125 levels above 35U/dL (p = 0.187). The median levels of CA125 were higher in the pleural fluid than in the serum in all aetiological groups. Higher serum CA125 levels were more likely to be found in patients with moderate to large effusions (p = 0.015), malignant effusions (p = 0.001) and in female patients (0.016). Serum CA125 level showed significant correlation with pleural fluid CA125 level (r = 0.532, p < 0.001) but not with pleural fluid total white blood cell count (r = -0.092, p = 0.362), red blood cell count (r = -0.082, p = 0.417) and lactate dehydrogenase level (r = 0.062, p = 0.541). We conclude that serum CA125 is commonly elevated in patients with benign and malignant pleural effusions. Malaysian Medical Association 2006 Article PeerReviewed application/pdf en http://irep.iium.edu.my/3662/1/Serum_Cancer_Antigen_125.pdf How, Soon Hin and Liam, C K and Ab Rahman, Jamalludin and Chin, S P and Zal, A. B. (2006) Serum cancer antigen 125 in patients with pleural effusions. The Medical Journal of Malaysia, 61 (5). pp. 558-563. ISSN 0300-5283 http://www.e-mjm.org/2006/v61n5/Serum_Cancer_Antigen_125.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) How, Soon Hin Liam, C K Ab Rahman, Jamalludin Chin, S P Zal, A. B. Serum cancer antigen 125 in patients with pleural effusions
description	We studied the prevalence of raised serum CA125 in patients with pleural effusions and explored factors affecting its level. Sixty four patients with benign effusions and 36 patients with malignant effusions admitted to the University Malaya Medical Centre from May 2001 to January 2002 were included in the study. There were no significant differences in age, gender and ethnicity of the patients with benign and malignant effusions. There was also no difference in the frequency of the side of pleural effusion between the two groups but compared to benign effusions, a higher proportion of malignant effusions was moderate to large in size (66% versus 39%, p = 0.011). Serum CA125 levels were above 35U/dL in 83.3% and 78.1% of patients with malignant and benign effusions, respectively (p = 0.532). All patients with underlying malignancy and 95.3% of patients with benign effusions had pleural fluid CA125 levels above 35U/dL (p = 0.187). The median levels of CA125 were higher in the pleural fluid than in the serum in all aetiological groups. Higher serum CA125 levels were more likely to be found in patients with moderate to large effusions (p = 0.015), malignant effusions (p = 0.001) and in female patients (0.016). Serum CA125 level showed significant correlation with pleural fluid CA125 level (r = 0.532, p < 0.001) but not with pleural fluid total white blood cell count (r = -0.092, p = 0.362), red blood cell count (r = -0.082, p = 0.417) and lactate dehydrogenase level (r = 0.062, p = 0.541). We conclude that serum CA125 is commonly elevated in patients with benign and malignant pleural effusions.
format	Article
author	How, Soon Hin Liam, C K Ab Rahman, Jamalludin Chin, S P Zal, A. B.
author_facet	How, Soon Hin Liam, C K Ab Rahman, Jamalludin Chin, S P Zal, A. B.
author_sort	How, Soon Hin
title	Serum cancer antigen 125 in patients with pleural effusions
title_short	Serum cancer antigen 125 in patients with pleural effusions
title_full	Serum cancer antigen 125 in patients with pleural effusions
title_fullStr	Serum cancer antigen 125 in patients with pleural effusions
title_full_unstemmed	Serum cancer antigen 125 in patients with pleural effusions
title_sort	serum cancer antigen 125 in patients with pleural effusions
publisher	Malaysian Medical Association
publishDate	2006
url	http://irep.iium.edu.my/3662/ http://irep.iium.edu.my/3662/ http://irep.iium.edu.my/3662/1/Serum_Cancer_Antigen_125.pdf
first_indexed	2023-09-18T20:11:34Z
last_indexed	2023-09-18T20:11:34Z
_version_	1777407512497094656

Serum cancer antigen 125 in patients with pleural effusions

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