Changes in trends and pattern of strong opioid prescribing in primary care

Background: This study evaluated the prescribing trends of four commonly prescribed strong opioids in primary care and explored utilization in non-cancer and cancer users. Methods: This cross-sectional study was conducted from 2000 to 2010 using the UK Clinical Practice Research Datalink. Prescri...

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Main Authors:	Zin, Che Suraya, Chen, Li-Chia, Knaggs, Roger D
Format:	Article
Language:	English English
Published:	European Pain Federation 2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/36513/ http://irep.iium.edu.my/36513/ http://irep.iium.edu.my/36513/ http://irep.iium.edu.my/36513/4/ejp496_36513.pdf http://irep.iium.edu.my/36513/7/36513_Changes%20in%20trends%20and%20pattern_SCOPUS.pdf

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recordtype	eprints
spelling	iium-365132017-09-19T08:45:16Z http://irep.iium.edu.my/36513/ Changes in trends and pattern of strong opioid prescribing in primary care Zin, Che Suraya Chen, Li-Chia Knaggs, Roger D RS Pharmacy and materia medica Background: This study evaluated the prescribing trends of four commonly prescribed strong opioids in primary care and explored utilization in non-cancer and cancer users. Methods: This cross-sectional study was conducted from 2000 to 2010 using the UK Clinical Practice Research Datalink. Prescriptions ofbuprenorphine, fentanyl, morphine and oxycodone issued to adult patients were included in this study. Opioid prescriptions issued after patients had cancer medical codes were defined as cancer-related use; otherwise, they were considered non-cancer use. Annual number of prescriptions and patients, defined daily dose (DDD/1000 inhabitants/day) and oral morphine equivalent (OMEQ) dose were measured in repeat cross-sectional estimates. Results: In total, there were 2,672,022 prescriptions (87.8% for non-cancer) of strong opioids for 178,692 users (59.9% female, 83.9%non-cancer, mean age 67.1±17.0 years) during the study period. The mean annual (DDD/1000 inhabitants/day) was higher in the non-cancer group than in the cancer group for all four opioids; morphine (0.73±0.28vs. 0.12± 0.04), fentanyl (0.46±0.29 vs. 0.06±0.24), oxycodone(0.24±0.19 vs. 0.038±0.028) and buprenorphine (0.23±0.15 vs.0.008±0.006). The highest proportion of patients were prescribed lowopioid doses (OMEQ≤50 mg/day) in both non-cancer (50.3%) andcancer (39.9%) groups, followed by the dose ranks of 51–100 mg/day (26.2% vs. 28.7%), 101–200 mg/day (15.1% vs. 19.2%) and>200 mg/day (8.25% vs. 12.1%). Conclusions: There has been a huge increase in strong opioid prescribing in the United Kingdom, with the majority of prescriptions for non-cancer pain. Morphine was the most frequently prescribed, but the utilization of oxycodone, buprenorphine and fentanyl increased markedly over time European Pain Federation 2014-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/36513/4/ejp496_36513.pdf application/pdf en http://irep.iium.edu.my/36513/7/36513_Changes%20in%20trends%20and%20pattern_SCOPUS.pdf Zin, Che Suraya and Chen, Li-Chia and Knaggs, Roger D (2014) Changes in trends and pattern of strong opioid prescribing in primary care. European Journal of Pain, 18 (9). pp. 1343-1351. ISSN 1532-2149 http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291532-2149/earlyview 10.1002/j.1532-2149.2014.496.x
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Zin, Che Suraya Chen, Li-Chia Knaggs, Roger D Changes in trends and pattern of strong opioid prescribing in primary care
description	Background: This study evaluated the prescribing trends of four commonly prescribed strong opioids in primary care and explored utilization in non-cancer and cancer users. Methods: This cross-sectional study was conducted from 2000 to 2010 using the UK Clinical Practice Research Datalink. Prescriptions ofbuprenorphine, fentanyl, morphine and oxycodone issued to adult patients were included in this study. Opioid prescriptions issued after patients had cancer medical codes were defined as cancer-related use; otherwise, they were considered non-cancer use. Annual number of prescriptions and patients, defined daily dose (DDD/1000 inhabitants/day) and oral morphine equivalent (OMEQ) dose were measured in repeat cross-sectional estimates. Results: In total, there were 2,672,022 prescriptions (87.8% for non-cancer) of strong opioids for 178,692 users (59.9% female, 83.9%non-cancer, mean age 67.1±17.0 years) during the study period. The mean annual (DDD/1000 inhabitants/day) was higher in the non-cancer group than in the cancer group for all four opioids; morphine (0.73±0.28vs. 0.12± 0.04), fentanyl (0.46±0.29 vs. 0.06±0.24), oxycodone(0.24±0.19 vs. 0.038±0.028) and buprenorphine (0.23±0.15 vs.0.008±0.006). The highest proportion of patients were prescribed lowopioid doses (OMEQ≤50 mg/day) in both non-cancer (50.3%) andcancer (39.9%) groups, followed by the dose ranks of 51–100 mg/day (26.2% vs. 28.7%), 101–200 mg/day (15.1% vs. 19.2%) and>200 mg/day (8.25% vs. 12.1%). Conclusions: There has been a huge increase in strong opioid prescribing in the United Kingdom, with the majority of prescriptions for non-cancer pain. Morphine was the most frequently prescribed, but the utilization of oxycodone, buprenorphine and fentanyl increased markedly over time
format	Article
author	Zin, Che Suraya Chen, Li-Chia Knaggs, Roger D
author_facet	Zin, Che Suraya Chen, Li-Chia Knaggs, Roger D
author_sort	Zin, Che Suraya
title	Changes in trends and pattern of strong opioid prescribing in primary care
title_short	Changes in trends and pattern of strong opioid prescribing in primary care
title_full	Changes in trends and pattern of strong opioid prescribing in primary care
title_fullStr	Changes in trends and pattern of strong opioid prescribing in primary care
title_full_unstemmed	Changes in trends and pattern of strong opioid prescribing in primary care
title_sort	changes in trends and pattern of strong opioid prescribing in primary care
publisher	European Pain Federation
publishDate	2014
url	http://irep.iium.edu.my/36513/ http://irep.iium.edu.my/36513/ http://irep.iium.edu.my/36513/ http://irep.iium.edu.my/36513/4/ejp496_36513.pdf http://irep.iium.edu.my/36513/7/36513_Changes%20in%20trends%20and%20pattern_SCOPUS.pdf
first_indexed	2023-09-18T20:52:19Z
last_indexed	2023-09-18T20:52:19Z
_version_	1777410076811722752

Changes in trends and pattern of strong opioid prescribing in primary care

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