QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists

Flavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation, atherosclerosis, asthma and thrombosis. The PAF actions can be inhibited by blocking its receptor with an antagonist. The aim of this...

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Main Authors:	Abdullah, Nor Hayati, Kiong, Ling Sui, Noorbatcha, Ibrahim Ali
Format:	Article
Language:	English English
Published:	AENSI Publications 2014
Subjects:	TP Chemical technology TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/36396/ http://irep.iium.edu.my/36396/ http://irep.iium.edu.my/36396/1/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating.pdf http://irep.iium.edu.my/36396/2/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating_SCOPUS.pdf

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spelling	iium-363962017-09-20T08:20:18Z http://irep.iium.edu.my/36396/ QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali TP Chemical technology TP248.13 Biotechnology Flavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation, atherosclerosis, asthma and thrombosis. The PAF actions can be inhibited by blocking its receptor with an antagonist. The aim of this study was to find the structure activity relationship between the PAF receptor binding antagonist activity and the structure based properties of flavonoids 1-11 by using quantum chemical quantitative structure activity relationship (QSAR) approach. The semi-empirical quantum chemical method was used to optimize the molecular structures of the flavanoids and various quantum chemical descriptors were calculated from the optimized structures. Heuristic and multi-linear regression methods were used to determine the correlation between the quantum chemical properties and the experimental PAF receptor binding inhibitory activity. The best correlation equation was obtained using multi-linear correlation method with three descriptors and correlation coefficient, R2= 0.9632 AENSI Publications 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/36396/1/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating.pdf application/pdf en http://irep.iium.edu.my/36396/2/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating_SCOPUS.pdf Abdullah, Nor Hayati and Kiong, Ling Sui and Noorbatcha, Ibrahim Ali (2014) QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists. Advances in Environmental Biology, 8 (3 (special)). pp. 797-802. ISSN 1995-0756 http://www.aensiweb.com/aeb_Special_2014.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TP Chemical technology TP248.13 Biotechnology
spellingShingle	TP Chemical technology TP248.13 Biotechnology Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
description	Flavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation, atherosclerosis, asthma and thrombosis. The PAF actions can be inhibited by blocking its receptor with an antagonist. The aim of this study was to find the structure activity relationship between the PAF receptor binding antagonist activity and the structure based properties of flavonoids 1-11 by using quantum chemical quantitative structure activity relationship (QSAR) approach. The semi-empirical quantum chemical method was used to optimize the molecular structures of the flavanoids and various quantum chemical descriptors were calculated from the optimized structures. Heuristic and multi-linear regression methods were used to determine the correlation between the quantum chemical properties and the experimental PAF receptor binding inhibitory activity. The best correlation equation was obtained using multi-linear correlation method with three descriptors and correlation coefficient, R2= 0.9632
format	Article
author	Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali
author_facet	Abdullah, Nor Hayati Kiong, Ling Sui Noorbatcha, Ibrahim Ali
author_sort	Abdullah, Nor Hayati
title	QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
title_short	QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
title_full	QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
title_fullStr	QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
title_full_unstemmed	QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists
title_sort	qsar study of flavonoids as platelet-activating factor (paf) receptor binding antagonists
publisher	AENSI Publications
publishDate	2014
url	http://irep.iium.edu.my/36396/ http://irep.iium.edu.my/36396/ http://irep.iium.edu.my/36396/1/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating.pdf http://irep.iium.edu.my/36396/2/36396_QSAR%20study%20of%20flavonoids%20as%20platelet-activating_SCOPUS.pdf
first_indexed	2023-09-18T20:52:09Z
last_indexed	2023-09-18T20:52:09Z
_version_	1777410065343447040

QSAR study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists

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