Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix

Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surfa...

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Main Authors:	Senjoti, Faria Gias, Jaffri, Juliana Md., Mandal, Uttam Kumar
Format:	Conference or Workshop Item
Language:	English
Published:	2014
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/36315/ http://irep.iium.edu.my/36315/ http://irep.iium.edu.my/36315/1/Published_paper.pdf

id	iium-36315
recordtype	eprints
spelling	iium-363152018-06-25T00:39:40Z http://irep.iium.edu.my/36315/ Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar RS Pharmacy and materia medica Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surface methodology (RSM) utilizing Box Behnken experimental design. The optimized tablets were further characterized by surface morphology, drug release kinetics, accelerated stability study etc. The optimized tablets enabled to float for more than 24 h and sustained the drug release for 12 h. 2014 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/36315/1/Published_paper.pdf Senjoti, Faria Gias and Jaffri, Juliana Md. and Mandal, Uttam Kumar (2014) Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix. In: International Conference on Pharmaceutical Sciences and Biomedical and Chemical Engineering, February 19 to 20, 2014, Kuala Lumpur. http://isro.eu.com/Mal_Proceed/pdf%2019.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
description	Gastro retentive tablets of metformin HCl were prepared based on polymer swelling and gas formation. Combination of HPMC and polyethylene oxide was used as both matrix forming agent and swelling agent, while sodium bicarbonate as gas forming agent. Fabricated tablets were optimized by response surface methodology (RSM) utilizing Box Behnken experimental design. The optimized tablets were further characterized by surface morphology, drug release kinetics, accelerated stability study etc. The optimized tablets enabled to float for more than 24 h and sustained the drug release for 12 h.
format	Conference or Workshop Item
author	Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar
author_facet	Senjoti, Faria Gias Jaffri, Juliana Md. Mandal, Uttam Kumar
author_sort	Senjoti, Faria Gias
title	Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
title_short	Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
title_full	Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
title_fullStr	Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
title_full_unstemmed	Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix
title_sort	fabrication and optimization of gastro retentive drug delivery system with hpmc and polyethylene oxide (peo) matrix
publishDate	2014
url	http://irep.iium.edu.my/36315/ http://irep.iium.edu.my/36315/ http://irep.iium.edu.my/36315/1/Published_paper.pdf
first_indexed	2023-09-18T20:52:00Z
last_indexed	2023-09-18T20:52:00Z
_version_	1777410056857321472

Fabrication and optimization of gastro retentive drug delivery system with HPMC and polyethylene oxide (PEO) matrix

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