The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet

The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet

Hyperhomocysteinemia is a risk factor for cardiovascular diseases. It is associated with an increase in oxidative stress. We aimed to study the effects of palm tocotrienol rich fraction (palm TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. Forty-two male Wistar rats w...

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Main Authors: Ku Zaifah, Norsidah, Ahmad Yusof, Asmadi, Ayob, Azizi, Yusuf, Kamisah
Format: Article
Language:English
Published: Lippincott Williams & Wilkins 2009
Subjects:
RM300 Drugs and their action
Online Access:http://irep.iium.edu.my/36103/
http://irep.iium.edu.my/36103/
http://irep.iium.edu.my/36103/
http://irep.iium.edu.my/36103/1/Ku_Zaifah_N_2009.pdf
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recordtype eprints
spelling iium-361032015-04-07T04:31:49Z http://irep.iium.edu.my/36103/ The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet Ku Zaifah, Norsidah Ahmad Yusof, Asmadi Ayob, Azizi Yusuf, Kamisah RM300 Drugs and their action Hyperhomocysteinemia is a risk factor for cardiovascular diseases. It is associated with an increase in oxidative stress. We aimed to study the effects of palm tocotrienol rich fraction (palm TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control. Groups two through six were fed 1% methionine diet for 10 weeks. From week six onward, folate (8 mg/kg diet) or palm TRF (30, 60 or 150 mg/kg diet) were added into the diet of groups three (M + Folate), four (M + TFR30), five (M + TRF60) and six (M + TRF150) respectively. Body weights were recorded weekly. No significant difference in body weight was recorded. Methionine diet (M) significantly raised the plasma homocysteine (tHcy level) and this was reduced by the supplementations of palm TRF at 150 mg/kg diet and folate. The dietary methionine increased aortic lipid peroxidation as shown by the increase in TBARS (604.0 +/- 51.0 pmol MDA/ mg protein, P < 0.05). - See more at: http://www.nursingcenter.com/lnc/JournalArticle?Article_ID=2412948&Journal_ID=1658605&Issue_ID=2412900#sthash.VqFndvF4.dpuf Lippincott Williams & Wilkins 2009-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/36103/1/Ku_Zaifah_N_2009.pdf Ku Zaifah, Norsidah and Ahmad Yusof, Asmadi and Ayob, Azizi and Yusuf, Kamisah (2009) The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. International Journal of Evidence-Based Healthcare, 7 (3). p. 214. ISSN 1744-1609 http://onlinelibrary.wiley.com/doi/10.1111/jbr.2009.7.issue-3/issuetoc 10.1111/j.1744-1609.2009.00141.x
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RM300 Drugs and their action
spellingShingle RM300 Drugs and their action
Ku Zaifah, Norsidah
Ahmad Yusof, Asmadi
Ayob, Azizi
Yusuf, Kamisah
The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet
description Hyperhomocysteinemia is a risk factor for cardiovascular diseases. It is associated with an increase in oxidative stress. We aimed to study the effects of palm tocotrienol rich fraction (palm TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control. Groups two through six were fed 1% methionine diet for 10 weeks. From week six onward, folate (8 mg/kg diet) or palm TRF (30, 60 or 150 mg/kg diet) were added into the diet of groups three (M + Folate), four (M + TFR30), five (M + TRF60) and six (M + TRF150) respectively. Body weights were recorded weekly. No significant difference in body weight was recorded. Methionine diet (M) significantly raised the plasma homocysteine (tHcy level) and this was reduced by the supplementations of palm TRF at 150 mg/kg diet and folate. The dietary methionine increased aortic lipid peroxidation as shown by the increase in TBARS (604.0 +/- 51.0 pmol MDA/ mg protein, P < 0.05). - See more at: http://www.nursingcenter.com/lnc/JournalArticle?Article_ID=2412948&Journal_ID=1658605&Issue_ID=2412900#sthash.VqFndvF4.dpuf
format Article
author Ku Zaifah, Norsidah
Ahmad Yusof, Asmadi
Ayob, Azizi
Yusuf, Kamisah
author_facet Ku Zaifah, Norsidah
Ahmad Yusof, Asmadi
Ayob, Azizi
Yusuf, Kamisah
author_sort Ku Zaifah, Norsidah
title The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet
title_short The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet
title_full The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet
title_fullStr The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet
title_full_unstemmed The effects of palm tocotrienol rich fraction (TRF) on proatherosclerotic changes in aorta of rats fed a high methionine diet
title_sort effects of palm tocotrienol rich fraction (trf) on proatherosclerotic changes in aorta of rats fed a high methionine diet
publisher Lippincott Williams & Wilkins
publishDate 2009
url http://irep.iium.edu.my/36103/
http://irep.iium.edu.my/36103/
http://irep.iium.edu.my/36103/
http://irep.iium.edu.my/36103/1/Ku_Zaifah_N_2009.pdf
first_indexed 2023-09-18T20:51:41Z
last_indexed 2023-09-18T20:51:41Z
_version_ 1777410036755070976

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