Evaluation of antimalaria activity and acute toxicity of Xetospongia sp
We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and esta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Science Publications
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/35947/ http://irep.iium.edu.my/35947/ http://irep.iium.edu.my/35947/1/journal_malaria_syamsul.pdf |
| Summary: | We investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA
and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened
for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute
toxicity of extracts of Xetospongia sp at the dose 5000 mg kg-1 on mice administeredorally exhibited no
toxicity, as evident in that fact that no histopathological changes were observed in some essential organs, such
as liver, heart, digestive tract and kidney. The ethanolic extracts (50-400 mg kg day-1) exhibited a significant
antimalarial activity both in the 4-day early infection test and in the established infection and they were found
to be relatively safe up to a dosage of 5000 mg kg-1, with an LD50 value of >500 mg kg-1. |
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