Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)

Wolfram syndrome (WFS) is a rare neurodegerative disorder which is characterized by presentation of diabetes insipidus, juvenile diabetes mellitus, optic atrophy and deafness. We describe a case of WFS with presentation of psychosis. A 17-year-old female presented with psychiatric manifestations, n...

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Main Authors:	Musa, Ramli, NNA, Fatnoon
Format:	Article
Language:	English
Published:	Malaysian Journal of Psychiatry 2014
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/35602/ http://irep.iium.edu.my/35602/ http://irep.iium.edu.my/35602/1/43.Wolfran_Syndrome.pdf

id	iium-35602
recordtype	eprints
spelling	iium-356022014-02-20T04:02:46Z http://irep.iium.edu.my/35602/ Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD) Musa, Ramli NNA, Fatnoon RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Wolfram syndrome (WFS) is a rare neurodegerative disorder which is characterized by presentation of diabetes insipidus, juvenile diabetes mellitus, optic atrophy and deafness. We describe a case of WFS with presentation of psychosis. A 17-year-old female presented with psychiatric manifestations, namely inappropriate behaviour and second person auditory hallucination since the age of 16 years. The patient was diagnosed with type 1 diabetes mellitus at the age of 10 years old and subsequently progressive hearing and visual loss a year later. Her ophthalmic evaluation revealed total blindness due to optic atrophy. However she did not have renal dysfunction and diabetes insipidus which are also features of the syndrome. There is scarce literature to describe on psychiatric presentation in WFS. In the past,the psychiatric manifestation which was reported most of times was mood and suicidal behaviour. Hardly any article reported about psychosis (hallucination). We believe, her psychiatric manifestations were related to sensory deprivation due to blindness and deafness caused by the progression of WFS. Malaysian Journal of Psychiatry 2014 Article PeerReviewed application/pdf en http://irep.iium.edu.my/35602/1/43.Wolfran_Syndrome.pdf Musa, Ramli and NNA, Fatnoon (2014) Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD). Malaysian Journal of Psychiatry, 23 (1). ISSN 0128-8628 http://www.mjpsychiatry.org/index.php/mjp/article/view/281
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Musa, Ramli NNA, Fatnoon Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)
description	Wolfram syndrome (WFS) is a rare neurodegerative disorder which is characterized by presentation of diabetes insipidus, juvenile diabetes mellitus, optic atrophy and deafness. We describe a case of WFS with presentation of psychosis. A 17-year-old female presented with psychiatric manifestations, namely inappropriate behaviour and second person auditory hallucination since the age of 16 years. The patient was diagnosed with type 1 diabetes mellitus at the age of 10 years old and subsequently progressive hearing and visual loss a year later. Her ophthalmic evaluation revealed total blindness due to optic atrophy. However she did not have renal dysfunction and diabetes insipidus which are also features of the syndrome. There is scarce literature to describe on psychiatric presentation in WFS. In the past,the psychiatric manifestation which was reported most of times was mood and suicidal behaviour. Hardly any article reported about psychosis (hallucination). We believe, her psychiatric manifestations were related to sensory deprivation due to blindness and deafness caused by the progression of WFS.
format	Article
author	Musa, Ramli NNA, Fatnoon
author_facet	Musa, Ramli NNA, Fatnoon
author_sort	Musa, Ramli
title	Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)
title_short	Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)
title_full	Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)
title_fullStr	Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)
title_full_unstemmed	Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)
title_sort	psychotic manifestation in a patient with wolfram syndrome (didmoad)
publisher	Malaysian Journal of Psychiatry
publishDate	2014
url	http://irep.iium.edu.my/35602/ http://irep.iium.edu.my/35602/ http://irep.iium.edu.my/35602/1/43.Wolfran_Syndrome.pdf
first_indexed	2023-09-18T20:51:00Z
last_indexed	2023-09-18T20:51:00Z
_version_	1777409993982607360

Psychotic manifestation in a patient with Wolfram syndrome (DIDMOAD)

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