Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period

The mood changes during pregnancy and postpartum period was recorded in 104 women belonging to various ethnic groups. The study was conducted in a hospital after institutional approval for the consented females. The information were recorded by interview of the study subject using a validated questi...

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Main Authors:	Helaluddin , Abul Bashar Mohammed, Khan, Umeed Ali, Saeed , Mohammad, Zainuddin, Ahmad Murad
Format:	Article
Language:	English
Published:	University of Peshawar 2012
Subjects:	QD Chemistry RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/34831/ http://irep.iium.edu.my/34831/ http://irep.iium.edu.my/34831/1/Blood_levels_of_tryptophan_and_serotonin_and_their_relationships_with_mood_.....pdf

id	iium-34831
recordtype	eprints
spelling	iium-348312014-01-30T01:54:14Z http://irep.iium.edu.my/34831/ Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period Helaluddin , Abul Bashar Mohammed Khan, Umeed Ali Saeed , Mohammad Zainuddin, Ahmad Murad QD Chemistry RS Pharmacy and materia medica The mood changes during pregnancy and postpartum period was recorded in 104 women belonging to various ethnic groups. The study was conducted in a hospital after institutional approval for the consented females. The information were recorded by interview of the study subject using a validated questionnaire. The analysis of questionnaire showed that 23.08% (24) women were clinically depressed during pregnancy and, 22.61 % (23) women after childbirth. However these 23 women included 8 women who were already depressed prenatally. On exclusion of these 8 cases, the postnatal depression was observed in 14.4%. Thirty (29.76%) women experienced a brief period of "pathological" happiness (joy of motherhood) after childbirth. The levels of serotonin and tryptophan were determined in two groups of subjects identified as who experienced depression during pregnancy and after childbirth. The blood samples (during pregnancy and postpartum period) were analysed for serotonin and tryptophan quantification using a validated HPLC method. The tryptophan level in prenatal depression and postpartum depression was found to be 12.7 ±2.5 and 11.9 ±2.4 ng/ml, respectively and that of the serotonin was 7.4 ± 1.8 and 7.7 ±1.7 ng/ml, respectively in the above groups. It was concluded that the blood level of tryptophan and serotonin can guide us in the prevention and control of depression. University of Peshawar 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/34831/1/Blood_levels_of_tryptophan_and_serotonin_and_their_relationships_with_mood_.....pdf Helaluddin , Abul Bashar Mohammed and Khan, Umeed Ali and Saeed , Mohammad and Zainuddin, Ahmad Murad (2012) Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period. Journal of Science and Technology, 36 (1 & 2). pp. 31-36. ISSN 0250 - 5339 http://www.upesh.edu.pk/oldhtml/academics/researchcenter/nceg/jstncegannualarchieves.php
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry RS Pharmacy and materia medica
spellingShingle	QD Chemistry RS Pharmacy and materia medica Helaluddin , Abul Bashar Mohammed Khan, Umeed Ali Saeed , Mohammad Zainuddin, Ahmad Murad Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period
description	The mood changes during pregnancy and postpartum period was recorded in 104 women belonging to various ethnic groups. The study was conducted in a hospital after institutional approval for the consented females. The information were recorded by interview of the study subject using a validated questionnaire. The analysis of questionnaire showed that 23.08% (24) women were clinically depressed during pregnancy and, 22.61 % (23) women after childbirth. However these 23 women included 8 women who were already depressed prenatally. On exclusion of these 8 cases, the postnatal depression was observed in 14.4%. Thirty (29.76%) women experienced a brief period of "pathological" happiness (joy of motherhood) after childbirth. The levels of serotonin and tryptophan were determined in two groups of subjects identified as who experienced depression during pregnancy and after childbirth. The blood samples (during pregnancy and postpartum period) were analysed for serotonin and tryptophan quantification using a validated HPLC method. The tryptophan level in prenatal depression and postpartum depression was found to be 12.7 ±2.5 and 11.9 ±2.4 ng/ml, respectively and that of the serotonin was 7.4 ± 1.8 and 7.7 ±1.7 ng/ml, respectively in the above groups. It was concluded that the blood level of tryptophan and serotonin can guide us in the prevention and control of depression.
format	Article
author	Helaluddin , Abul Bashar Mohammed Khan, Umeed Ali Saeed , Mohammad Zainuddin, Ahmad Murad
author_facet	Helaluddin , Abul Bashar Mohammed Khan, Umeed Ali Saeed , Mohammad Zainuddin, Ahmad Murad
author_sort	Helaluddin , Abul Bashar Mohammed
title	Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period
title_short	Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period
title_full	Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period
title_fullStr	Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period
title_full_unstemmed	Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period
title_sort	blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period
publisher	University of Peshawar
publishDate	2012
url	http://irep.iium.edu.my/34831/ http://irep.iium.edu.my/34831/ http://irep.iium.edu.my/34831/1/Blood_levels_of_tryptophan_and_serotonin_and_their_relationships_with_mood_.....pdf
first_indexed	2023-09-18T20:50:06Z
last_indexed	2023-09-18T20:50:06Z
_version_	1777409937248354304

Blood levels of serotonin and tryptophan and their relationship with mood changes during pregnancy and postpartum period

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