In vitro antifungal activity of Rhazya stricta

In vitro antifungal activity of Rhazya stricta

Rhazya stricta is a small glabrous shrub, widely distributed throughout Western Asia from Yemen to Arabia, to the North West Province of India and abundantly found in various regions of Pakistan. Larvicidal and antifungal studies of polar and non polar aerial parts extracts of Rhazya stricta were pe...

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Main Author: Khan, Saifullah
Format: Article
Language:English
Published: PubMed 2007
Subjects:
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/34647/
http://irep.iium.edu.my/34647/
http://irep.iium.edu.my/34647/3/In_vitro_antifungal_PJPS_20_%28274-279%29_2007.pdf
id iium-34647
recordtype eprints
spelling iium-346472014-05-22T00:39:55Z http://irep.iium.edu.my/34647/ In vitro antifungal activity of Rhazya stricta Khan, Saifullah RS Pharmacy and materia medica Rhazya stricta is a small glabrous shrub, widely distributed throughout Western Asia from Yemen to Arabia, to the North West Province of India and abundantly found in various regions of Pakistan. Larvicidal and antifungal studies of polar and non polar aerial parts extracts of Rhazya stricta were performed using brine shrimps larvae for larvicidal study and for antifungal study microorganisms, Trichophyton longifusis, Aspergillus flavus, Candida albicans, Microsporum canis and Fusarium solani were used respectively. The methanol fraction showed significant cytotoxicity with LC50 17.809 microg/ml, having mortality rate 73.33% at highest dose. While pet-ether, chloroform and carbon tetrachloride possessed moderate to low cytotoxicity with their LC50 values 49.077 microg/ml, 95.859 microg/ml and 80.489 microg/ml respectively, ethyl acetate fraction showed no cytotoxicity. Results of antifungal studies showed that fractionated samples of methanol and chloroform possessed significant antifungal activities against, Trichophyton longifusis, Aspergillus flavus, Candida albicans and Fusarium solani respectively. Due to these promising results, further in vivo studies over R. stricta must be conducted. PubMed 2007-10 Article PeerReviewed application/pdf en http://irep.iium.edu.my/34647/3/In_vitro_antifungal_PJPS_20_%28274-279%29_2007.pdf Khan, Saifullah (2007) In vitro antifungal activity of Rhazya stricta. Pak J Pharm Sci., 20 (4). pp. 274-279. ISSN 1011-601X http://www.pjps.pk/
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Khan, Saifullah
In vitro antifungal activity of Rhazya stricta
description Rhazya stricta is a small glabrous shrub, widely distributed throughout Western Asia from Yemen to Arabia, to the North West Province of India and abundantly found in various regions of Pakistan. Larvicidal and antifungal studies of polar and non polar aerial parts extracts of Rhazya stricta were performed using brine shrimps larvae for larvicidal study and for antifungal study microorganisms, Trichophyton longifusis, Aspergillus flavus, Candida albicans, Microsporum canis and Fusarium solani were used respectively. The methanol fraction showed significant cytotoxicity with LC50 17.809 microg/ml, having mortality rate 73.33% at highest dose. While pet-ether, chloroform and carbon tetrachloride possessed moderate to low cytotoxicity with their LC50 values 49.077 microg/ml, 95.859 microg/ml and 80.489 microg/ml respectively, ethyl acetate fraction showed no cytotoxicity. Results of antifungal studies showed that fractionated samples of methanol and chloroform possessed significant antifungal activities against, Trichophyton longifusis, Aspergillus flavus, Candida albicans and Fusarium solani respectively. Due to these promising results, further in vivo studies over R. stricta must be conducted.
format Article
author Khan, Saifullah
author_facet Khan, Saifullah
author_sort Khan, Saifullah
title In vitro antifungal activity of Rhazya stricta
title_short In vitro antifungal activity of Rhazya stricta
title_full In vitro antifungal activity of Rhazya stricta
title_fullStr In vitro antifungal activity of Rhazya stricta
title_full_unstemmed In vitro antifungal activity of Rhazya stricta
title_sort in vitro antifungal activity of rhazya stricta
publisher PubMed
publishDate 2007
url http://irep.iium.edu.my/34647/
http://irep.iium.edu.my/34647/
http://irep.iium.edu.my/34647/3/In_vitro_antifungal_PJPS_20_%28274-279%29_2007.pdf
first_indexed 2023-09-18T20:49:52Z
last_indexed 2023-09-18T20:49:52Z
_version_ 1777409922205483008

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