A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease

Paraoxonase-1 (PON-1) is an HDL-associated enzyme which has been implicated in the pathogenesis of atherosclerosis by preventing lipid peroxide generation. The population variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Recent studies have suggested that PON-1 Q192R...

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Main Authors:	Muhammad Musa, Nurul Ashikin, Abdullah, Nor Zamzila, A.Talib, Norlelawati, Nik Ahmad, Nik Nur Fatnoon
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/34291/ http://irep.iium.edu.my/34291/1/poster_abstract_for_MSAB_symposium_2013.jpg

id	iium-34291
recordtype	eprints
spelling	iium-342912014-01-16T06:14:34Z http://irep.iium.edu.my/34291/ A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon RB Pathology Paraoxonase-1 (PON-1) is an HDL-associated enzyme which has been implicated in the pathogenesis of atherosclerosis by preventing lipid peroxide generation. The population variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Recent studies have suggested that PON-1 Q192R polymorphism is associated with coronary artery disease (CAD) in different ethnic populations. However to this date, there is no such study in Malaysia. The present study looks at PON-1 Q192R gene polymorphism among CAD patients and healthy controls in Kuantan, Pahang. This study consisted of 187 CAD patients and 188 healthy subjects. PON-1 Q192R genotypes were determined by polymerase chain reaction (PCR) and AlwI restriction enzyme digestion. The Q192R polymorphism was significantly associated with CAD (p = 0.004), where the 192R allele was found to be more frequent in CAD patients than controls (0.618 vs 0.513) with QR genotype being the commonest (45.5%), followed by RR (39.0%) and QQ (15.5%) genotypes. In conclusion, the PON-1 Q192R polymorphism is significantly associated with CAD. This finding indicates that this gene variation is a useful genetic marker for CAD in our population. However, a multicentre study may be required to confirm our findings in Malaysian population. 2013 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/34291/1/poster_abstract_for_MSAB_symposium_2013.jpg Muhammad Musa, Nurul Ashikin and Abdullah, Nor Zamzila and A.Talib, Norlelawati and Nik Ahmad, Nik Nur Fatnoon (2013) A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease. In: 9th National Biology Symposium, 28-30 May 2013, Thistle Port Dickson Resort, Negeri Sembilan.. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease
description	Paraoxonase-1 (PON-1) is an HDL-associated enzyme which has been implicated in the pathogenesis of atherosclerosis by preventing lipid peroxide generation. The population variability in this enzyme activity is attributed to polymorphism in PON-1 gene. Recent studies have suggested that PON-1 Q192R polymorphism is associated with coronary artery disease (CAD) in different ethnic populations. However to this date, there is no such study in Malaysia. The present study looks at PON-1 Q192R gene polymorphism among CAD patients and healthy controls in Kuantan, Pahang. This study consisted of 187 CAD patients and 188 healthy subjects. PON-1 Q192R genotypes were determined by polymerase chain reaction (PCR) and AlwI restriction enzyme digestion. The Q192R polymorphism was significantly associated with CAD (p = 0.004), where the 192R allele was found to be more frequent in CAD patients than controls (0.618 vs 0.513) with QR genotype being the commonest (45.5%), followed by RR (39.0%) and QQ (15.5%) genotypes. In conclusion, the PON-1 Q192R polymorphism is significantly associated with CAD. This finding indicates that this gene variation is a useful genetic marker for CAD in our population. However, a multicentre study may be required to confirm our findings in Malaysian population.
format	Conference or Workshop Item
author	Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon
author_facet	Muhammad Musa, Nurul Ashikin Abdullah, Nor Zamzila A.Talib, Norlelawati Nik Ahmad, Nik Nur Fatnoon
author_sort	Muhammad Musa, Nurul Ashikin
title	A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease
title_short	A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease
title_full	A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease
title_fullStr	A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease
title_full_unstemmed	A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease
title_sort	study of paraoxonase-1 192 gene polymorphism in coronary artery disease
publishDate	2013
url	http://irep.iium.edu.my/34291/ http://irep.iium.edu.my/34291/1/poster_abstract_for_MSAB_symposium_2013.jpg
first_indexed	2023-09-18T20:49:27Z
last_indexed	2023-09-18T20:49:27Z
_version_	1777409896196603904

A study of Paraoxonase-1 192 gene polymorphism in coronary artery disease

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