Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats

Summary. Toxicity study on normal rats was carried out using freeze-dried whole fruit (FDWF) sample of Baccaurea angulata. Animals in these sub-chronic studies illustrated no significant changes in general behaviour, growth, and relative organ weights. In liver function test, total protein and alkal...

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Main Authors:	Ibrahim, D., Hazali, Norazlanshah, Jauhari, N., Yahya, Mohammad Nor Adros, Ahmed, I. A., Mikail, Maryam Abimbola, Ibrahim, Muhammad
Format:	Article
Language:	English English
Published:	Healthy-Synergies Publications (USA) 2013
Subjects:	TX341 Nutrition. Foods and food supply
Online Access:	http://irep.iium.edu.my/34176/ http://irep.iium.edu.my/34176/ http://irep.iium.edu.my/34176/1/PUBLISHED_JOURNAL.pdf http://irep.iium.edu.my/34176/4/scopus.pdf

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recordtype	eprints
spelling	iium-341762014-11-22T04:09:33Z http://irep.iium.edu.my/34176/ Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats Ibrahim, D. Hazali, Norazlanshah Jauhari, N. Yahya, Mohammad Nor Adros Ahmed, I. A. Mikail, Maryam Abimbola Ibrahim, Muhammad TX341 Nutrition. Foods and food supply Summary. Toxicity study on normal rats was carried out using freeze-dried whole fruit (FDWF) sample of Baccaurea angulata. Animals in these sub-chronic studies illustrated no significant changes in general behaviour, growth, and relative organ weights. In liver function test, total protein and alkaline phosphatase significantly decreased in male treated Group-II (300 mg/kg), giving 36.50±2.65 g/L and 47.90±4.48 U/L, respectively. Meanwhile, low dose female group (Group-II), there was significant increase in the same parameters, giving 63.70±5.28 g/L and 73.50±12.91 U/L respectively. In general, there was no evidence that demonstrated any tissue injury, the no-observable adverse effect level for B. angulata was 1,200 mg/kg administered orally for 13 weeks. Industrial relevance. The whole fruit juice of B. angulata, one of underutilized fruits found in Borneo island of Malaysia, has the potential to be utilized for preparation of health drink. Our earlier studies on the fruit showed that it contains the essential nutrients including dietary fiber that are good in promoting human health. Besides that, it has also been found to contain essential amount of antioxidant constituents as confirmed by antioxidant activities. This present study, additionally, found it to be safe and thus offer diverse potentials to be developed for nutraceeutical and functional fruit product. Healthy-Synergies Publications (USA) 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/34176/1/PUBLISHED_JOURNAL.pdf application/pdf en http://irep.iium.edu.my/34176/4/scopus.pdf Ibrahim, D. and Hazali, Norazlanshah and Jauhari, N. and Yahya, Mohammad Nor Adros and Ahmed, I. A. and Mikail, Maryam Abimbola and Ibrahim, Muhammad (2013) Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats. International Journal of Applied Research in Natural Products, 6 (4). pp. 23-32. ISSN 1940-6223 http://www.ijarnp.org/index.php/ijarnp/article/view/226
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	TX341 Nutrition. Foods and food supply
spellingShingle	TX341 Nutrition. Foods and food supply Ibrahim, D. Hazali, Norazlanshah Jauhari, N. Yahya, Mohammad Nor Adros Ahmed, I. A. Mikail, Maryam Abimbola Ibrahim, Muhammad Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats
description	Summary. Toxicity study on normal rats was carried out using freeze-dried whole fruit (FDWF) sample of Baccaurea angulata. Animals in these sub-chronic studies illustrated no significant changes in general behaviour, growth, and relative organ weights. In liver function test, total protein and alkaline phosphatase significantly decreased in male treated Group-II (300 mg/kg), giving 36.50±2.65 g/L and 47.90±4.48 U/L, respectively. Meanwhile, low dose female group (Group-II), there was significant increase in the same parameters, giving 63.70±5.28 g/L and 73.50±12.91 U/L respectively. In general, there was no evidence that demonstrated any tissue injury, the no-observable adverse effect level for B. angulata was 1,200 mg/kg administered orally for 13 weeks. Industrial relevance. The whole fruit juice of B. angulata, one of underutilized fruits found in Borneo island of Malaysia, has the potential to be utilized for preparation of health drink. Our earlier studies on the fruit showed that it contains the essential nutrients including dietary fiber that are good in promoting human health. Besides that, it has also been found to contain essential amount of antioxidant constituents as confirmed by antioxidant activities. This present study, additionally, found it to be safe and thus offer diverse potentials to be developed for nutraceeutical and functional fruit product.
format	Article
author	Ibrahim, D. Hazali, Norazlanshah Jauhari, N. Yahya, Mohammad Nor Adros Ahmed, I. A. Mikail, Maryam Abimbola Ibrahim, Muhammad
author_facet	Ibrahim, D. Hazali, Norazlanshah Jauhari, N. Yahya, Mohammad Nor Adros Ahmed, I. A. Mikail, Maryam Abimbola Ibrahim, Muhammad
author_sort	Ibrahim, D.
title	Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats
title_short	Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats
title_full	Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats
title_fullStr	Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats
title_full_unstemmed	Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats
title_sort	sub-chronic toxicological evaluation of the baccaurea angulata (belimbing dayak) fruit juice in rats
publisher	Healthy-Synergies Publications (USA)
publishDate	2013
url	http://irep.iium.edu.my/34176/ http://irep.iium.edu.my/34176/ http://irep.iium.edu.my/34176/1/PUBLISHED_JOURNAL.pdf http://irep.iium.edu.my/34176/4/scopus.pdf
first_indexed	2023-09-18T20:49:19Z
last_indexed	2023-09-18T20:49:19Z
_version_	1777409887556337664

Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats

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