Sub-chronic toxicological evaluation of the Baccaurea angulata (Belimbing Dayak) fruit juice in rats
Summary. Toxicity study on normal rats was carried out using freeze-dried whole fruit (FDWF) sample of Baccaurea angulata. Animals in these sub-chronic studies illustrated no significant changes in general behaviour, growth, and relative organ weights. In liver function test, total protein and alkal...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Healthy-Synergies Publications (USA)
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/34176/ http://irep.iium.edu.my/34176/ http://irep.iium.edu.my/34176/1/PUBLISHED_JOURNAL.pdf http://irep.iium.edu.my/34176/4/scopus.pdf |
| Summary: | Summary. Toxicity study on normal rats was carried out using freeze-dried whole fruit (FDWF) sample of Baccaurea angulata. Animals in these sub-chronic studies illustrated no significant changes in general behaviour, growth, and relative organ weights. In liver function test, total protein and alkaline phosphatase significantly decreased in male treated Group-II (300 mg/kg), giving 36.50±2.65 g/L and 47.90±4.48 U/L, respectively. Meanwhile, low dose female group (Group-II), there was significant increase in the same parameters, giving 63.70±5.28 g/L and 73.50±12.91 U/L respectively. In general, there was no evidence that demonstrated any tissue injury, the no-observable adverse effect level for B. angulata was 1,200 mg/kg administered orally for 13 weeks.
Industrial relevance. The whole fruit juice of B. angulata, one of underutilized fruits found in Borneo island of Malaysia, has the potential to be utilized for preparation of health drink. Our earlier studies on the fruit showed that it contains the essential nutrients including dietary fiber that are good in promoting human health. Besides that, it has also been found to contain essential amount of antioxidant constituents as confirmed by antioxidant activities. This present study, additionally, found it to be safe and thus offer diverse potentials to be developed for nutraceeutical and functional fruit product. |
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