Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats
Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats...
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2012
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iium-338662015-12-18T02:43:37Z http://irep.iium.edu.my/33866/ Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats Al-Qaraghuli , Ahmed M.S. Nafie, Emad M. Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi QM Human anatomy RB Pathology RM300 Drugs and their action Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group) was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II (Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I. Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion.However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects. KEYWORDS: Ethanol, gastric ulcer, ranitidine, Xiang Sha Yang Wei Wan(XSYWW),traditional medicine. 2012-03 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/33866/1/Abstract_113_C.jpg application/pdf en http://irep.iium.edu.my/33866/2/Abstract_114_B.jpg application/pdf en http://irep.iium.edu.my/33866/3/Proceeding_Cover_01.jpg application/pdf en http://irep.iium.edu.my/33866/4/booklet_front_page_1.jpg Al-Qaraghuli , Ahmed M.S. and Nafie, Emad M. and Al-Ani, Imad Matloub Dally and Faisal, Ghasak Ghazi (2012) Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats. In: 10th International Conference of Bioactive Compound and Functional Foods in Health and Disease , 13-15 March, 2012, University of California , Santa Barbara, (UCSB USA.. |
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English English English English |
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QM Human anatomy RB Pathology RM300 Drugs and their action |
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QM Human anatomy RB Pathology RM300 Drugs and their action Al-Qaraghuli , Ahmed M.S. Nafie, Emad M. Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats |
| description |
Introduction: Xiang Sha Yang Wei Wan (XSYWW) is a Chinese traditional medicine that is used for gastrointestinal
disorders, specifically gastric ulcer in many countries of South-East Asia. The aim of the study was to evaluate
the potential effects of XSYWW on ethanol-induced gastric ulcer in rats by means of histological Study. On a
similar basis of treatment, ranitidine, a conventional medication was used as gold standard. Methods: Fifty
five male Sprague-Dawley rats (250-300 gm) were divided into four groups. Group I (ethanol treated group)
was the control group and gastric ulcers were induced by administering 100% ethanol (1 ml/200 g). Group II
(Pre-treatment group) was divided into two subgroups; they were orally fed with 1.0 gm/kg and 2.0 gm/kg
respectively of XSYWW solution. Thirty minutes later they were administered with absolute ethanol as in group I.
Group III, was given an oral dose of 2gm/kg of XSYWW solution after one hour of ethanol administration. Group
IV was given an oral dose of 200mg/kg ranitidine solution after one hour of ethanol administration. Five rats
from groups I, III and IV were sacrificed on day 1, 2 and 3 while the animals of group II were sacrificed one hour
after ethanol administration. Results: Histological study of the stomachs from ethanol treated rats showed multiple ulcers of various depths that reached the muscularis and the serosa. Conclusion: Pre or post-treated rats with XSYWW showed that XSYWW has protective effect against ethanol-induced gastric mucosal lesion.However, there was a faster and more complete healing process in the ranitidine treated group when compared to the XSYWW treated subjects.
KEYWORDS: Ethanol, gastric ulcer, ranitidine, Xiang Sha Yang Wei Wan(XSYWW),traditional medicine. |
| format |
Conference or Workshop Item |
| author |
Al-Qaraghuli , Ahmed M.S. Nafie, Emad M. Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi |
| author_facet |
Al-Qaraghuli , Ahmed M.S. Nafie, Emad M. Al-Ani, Imad Matloub Dally Faisal, Ghasak Ghazi |
| author_sort |
Al-Qaraghuli , Ahmed M.S. |
| title |
Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats |
| title_short |
Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats |
| title_full |
Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats |
| title_fullStr |
Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats |
| title_full_unstemmed |
Observational histological study on the healing process of the ethanol-induced gastric ulcer treated with Xiang Sha Yang Wei Wan in comparison to ranitidine treated sprague dawley rats |
| title_sort |
observational histological study on the healing process of the ethanol-induced gastric ulcer treated with xiang sha yang wei wan in comparison to ranitidine treated sprague dawley rats |
| publishDate |
2012 |
| url |
http://irep.iium.edu.my/33866/ http://irep.iium.edu.my/33866/1/Abstract_113_C.jpg http://irep.iium.edu.my/33866/2/Abstract_114_B.jpg http://irep.iium.edu.my/33866/3/Proceeding_Cover_01.jpg http://irep.iium.edu.my/33866/4/booklet_front_page_1.jpg |
| first_indexed |
2023-09-18T20:48:57Z |
| last_indexed |
2023-09-18T20:48:57Z |
| _version_ |
1777409864979447808 |