Effect of Pluchea Indica on glucose consumption of chang liver cells

Diabetes mellitus is a chronic metabolic disorder that has reached epidernic proportions with the estimated prevalence rates and trends are escalating largely in developing countries. Medicinal plants have been used as an option to treat diabeterand its complications. Our previous in vitro study has...

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Main Authors:	Suriyah, Wastuti, Taher, Muhammad, Ichwan, Solachuddin J. A., Kasmuri, Abdul Razak
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RM300 Drugs and their action RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/33813/ http://irep.iium.edu.my/33813/ http://irep.iium.edu.my/33813/1/MSPP_2013.pdf

id	iium-33813
recordtype	eprints
spelling	iium-338132014-01-08T01:37:25Z http://irep.iium.edu.my/33813/ Effect of Pluchea Indica on glucose consumption of chang liver cells Suriyah, Wastuti Taher, Muhammad Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak RM300 Drugs and their action RS Pharmacy and materia medica Diabetes mellitus is a chronic metabolic disorder that has reached epidernic proportions with the estimated prevalence rates and trends are escalating largely in developing countries. Medicinal plants have been used as an option to treat diabeterand its complications. Our previous in vitro study has revealed that P. indica extracts stimulated insulin secretion in pancreatic beta cells and increased glucose uptake in adipocytes. The present study was aimed to observe the activity of P. indica extracts in the stimulation of glucose consumption in Chang liver cells (CCL-13) as the model of hepatocytes analyzed by glucose oxidation method. P. indica leaves were extracted in a series of organic solvents (n-hexane, dichloromethane, ethylr acetate, and methanol) and water. The maximum tolerated concentration of the extracts was ditemrined based on the MTT assay at 0.2 mg/ml. We found that methanol extract significantly elevated glucose consumption in Chang liver cells (p30.05). This result indicated tlat tne extract was useful in enhancing glucose uptake into liver cells under basal state. Further study will be focused on the expression of genes involved in the glucose uptake induced by the extract 2013 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/33813/1/MSPP_2013.pdf Suriyah, Wastuti and Taher, Muhammad and Ichwan, Solachuddin J. A. and Kasmuri, Abdul Razak (2013) Effect of Pluchea Indica on glucose consumption of chang liver cells. In: 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP2013), 6-8 September 2013, MS Garden Kuantan. (Unpublished) http://www.mspp2013.com
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM300 Drugs and their action RS Pharmacy and materia medica
spellingShingle	RM300 Drugs and their action RS Pharmacy and materia medica Suriyah, Wastuti Taher, Muhammad Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak Effect of Pluchea Indica on glucose consumption of chang liver cells
description	Diabetes mellitus is a chronic metabolic disorder that has reached epidernic proportions with the estimated prevalence rates and trends are escalating largely in developing countries. Medicinal plants have been used as an option to treat diabeterand its complications. Our previous in vitro study has revealed that P. indica extracts stimulated insulin secretion in pancreatic beta cells and increased glucose uptake in adipocytes. The present study was aimed to observe the activity of P. indica extracts in the stimulation of glucose consumption in Chang liver cells (CCL-13) as the model of hepatocytes analyzed by glucose oxidation method. P. indica leaves were extracted in a series of organic solvents (n-hexane, dichloromethane, ethylr acetate, and methanol) and water. The maximum tolerated concentration of the extracts was ditemrined based on the MTT assay at 0.2 mg/ml. We found that methanol extract significantly elevated glucose consumption in Chang liver cells (p30.05). This result indicated tlat tne extract was useful in enhancing glucose uptake into liver cells under basal state. Further study will be focused on the expression of genes involved in the glucose uptake induced by the extract
format	Conference or Workshop Item
author	Suriyah, Wastuti Taher, Muhammad Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak
author_facet	Suriyah, Wastuti Taher, Muhammad Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak
author_sort	Suriyah, Wastuti
title	Effect of Pluchea Indica on glucose consumption of chang liver cells
title_short	Effect of Pluchea Indica on glucose consumption of chang liver cells
title_full	Effect of Pluchea Indica on glucose consumption of chang liver cells
title_fullStr	Effect of Pluchea Indica on glucose consumption of chang liver cells
title_full_unstemmed	Effect of Pluchea Indica on glucose consumption of chang liver cells
title_sort	effect of pluchea indica on glucose consumption of chang liver cells
publishDate	2013
url	http://irep.iium.edu.my/33813/ http://irep.iium.edu.my/33813/ http://irep.iium.edu.my/33813/1/MSPP_2013.pdf
first_indexed	2023-09-18T20:48:54Z
last_indexed	2023-09-18T20:48:54Z
_version_	1777409861680627712

Effect of Pluchea Indica on glucose consumption of chang liver cells

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