Celecoxib as a neuroprotective agent in chronic cerebral hypoperfusion-induced neurodegeneration in rats
Objectives: Reduced cerebral blood flow (CBF)has been associated with neurodegenerative disorders. Since neuroinflammation is thought to play a significant role in chronic degenerative neurological disorders like Alzheimer's disease, the present study was planned to,assess the neuroprotective...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English English English |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/33808/ http://irep.iium.edu.my/33808/ http://irep.iium.edu.my/33808/1/Oral_Presentation_Certificate.pdf http://irep.iium.edu.my/33808/2/Abstract.pdf http://irep.iium.edu.my/33808/3/Cover_Page.pdf |
| Summary: | Objectives: Reduced cerebral blood flow (CBF)has been associated with neurodegenerative disorders. Since neuroinflammation is thought to play a significant role in chronic degenerative neurological disorders like Alzheimer's
disease, the present study was planned to,assess the neuroprotective role of celecoxib in Alzheimer's model of rats(2VO).
Methods:Experimentally,a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent
bilateral occlusion of common carotid arteries (2VO)in rats.
After 1 week of acclimatization,fifteen Sprague Dawley rats weighing 200-250 g were equally divided into three groups. Group A served as - sham control, Group B - 2VO, and Group C - 2VO-C treated daily with celecoxib 50 mg/kg, orally following 2VO. On 8th week, all the rats were euthanized and
the hippocampi were isolated. Viable neuronal cells in the hippocampal CA-1 region were counted and hippocampal COX-2 mRNA expression and prostaglandin E2(PGE-2)levels were estimated.
Results: There was a significant difference in neuronal cell
death, increase in COX-2 mRNA expression and PGE-2 levels in
2VO group as compared to sham control group. In celecoxib-treated 2VO-C rats,the viable neuronal cell count of the
hippocampal CA-l region was significantly higher as compared
to the untreated 2VO group. The hippocampal COX-2 mRNA expression and hippocampal PGE-2 levels were found to be significantly lower in the celecoxib-treated 2VO rats as compared to untreated 2VO rats.
Conclusions: The results indicate that celecoxib could be successfully used in the management of Alzheimer's disease.
No conflict of interest. |
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