Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus

Orthosiphon stamineus Benth. (Orthosiphon grandiflorus Bold. or Clerodendranthus spicatus Thunb.) is an Indonesian medicinal herb traditionally used for diseases such as hypertension, diabetes, and kidney stones. Despite the importance of this last application, there are very few reports on it...

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Main Authors:	Yuliana, Nancy Dewi, Khatib, Alfi, Link-Struensee, Anne Maria Regina, Ijzerman, Adriaan P., Rungkat-Zakaria, Fransiska, Choi, Young Hae, Verpoorte, Robert
Format:	Article
Language:	English
Published:	Thieme Verlagsgruppe 2009
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/33741/ http://irep.iium.edu.my/33741/ http://irep.iium.edu.my/33741/ http://irep.iium.edu.my/33741/1/Yuliana_et_al._2009.pdf

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recordtype	eprints
spelling	iium-337412014-01-06T07:55:44Z http://irep.iium.edu.my/33741/ Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus Yuliana, Nancy Dewi Khatib, Alfi Link-Struensee, Anne Maria Regina Ijzerman, Adriaan P. Rungkat-Zakaria, Fransiska Choi, Young Hae Verpoorte, Robert QD Chemistry Orthosiphon stamineus Benth. (Orthosiphon grandiflorus Bold. or Clerodendranthus spicatus Thunb.) is an Indonesian medicinal herb traditionally used for diseases such as hypertension, diabetes, and kidney stones. Despite the importance of this last application, there are very few reports on it. Diuretic action is an important factor in kidney stone treatment, as an increase in the volume of fluid flowing through the kidney will help to dissolve the stones, assist their passing to avoid further retention, and flush out the deposits. Among the diverse roles of adenosine A1 receptor antagonists in renal protection, many studies have shown that they can induce diuresis and sodium excretion. A bioassay-guided fractionation of a methanol-water extract of Orthosiphon stamineus leaves using the adenosine A1 receptor binding assay resulted in the isolation of seven methoxy flavonoids as active ligands with Ki values in the micromolar range. The Hill slope values are not significantly different from unity (within 0.9–1.4), which indicates the antagonist effect to A1-R. The results of this study thus provide a scientific foundation for the traditional use of Orthosiphon stamineus in kidney stone treatment, as the affinity of the active compounds isolated from it as adenosine A1 receptor ligands allows them to be associated with diuretic activity, which is one possible treatment for renal lithiasis. Thieme Verlagsgruppe 2009-09-09 Article PeerReviewed application/pdf en http://irep.iium.edu.my/33741/1/Yuliana_et_al._2009.pdf Yuliana, Nancy Dewi and Khatib, Alfi and Link-Struensee, Anne Maria Regina and Ijzerman, Adriaan P. and Rungkat-Zakaria, Fransiska and Choi, Young Hae and Verpoorte, Robert (2009) Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus. Planta Medica, 75 (2). pp. 132-136. ISSN 0032-0943 https://www.thieme-connect.com/DOI/DOI?10.1055/s-0028-1088379 10.1055/s-0028-1088379
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Yuliana, Nancy Dewi Khatib, Alfi Link-Struensee, Anne Maria Regina Ijzerman, Adriaan P. Rungkat-Zakaria, Fransiska Choi, Young Hae Verpoorte, Robert Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
description	Orthosiphon stamineus Benth. (Orthosiphon grandiflorus Bold. or Clerodendranthus spicatus Thunb.) is an Indonesian medicinal herb traditionally used for diseases such as hypertension, diabetes, and kidney stones. Despite the importance of this last application, there are very few reports on it. Diuretic action is an important factor in kidney stone treatment, as an increase in the volume of fluid flowing through the kidney will help to dissolve the stones, assist their passing to avoid further retention, and flush out the deposits. Among the diverse roles of adenosine A1 receptor antagonists in renal protection, many studies have shown that they can induce diuresis and sodium excretion. A bioassay-guided fractionation of a methanol-water extract of Orthosiphon stamineus leaves using the adenosine A1 receptor binding assay resulted in the isolation of seven methoxy flavonoids as active ligands with Ki values in the micromolar range. The Hill slope values are not significantly different from unity (within 0.9–1.4), which indicates the antagonist effect to A1-R. The results of this study thus provide a scientific foundation for the traditional use of Orthosiphon stamineus in kidney stone treatment, as the affinity of the active compounds isolated from it as adenosine A1 receptor ligands allows them to be associated with diuretic activity, which is one possible treatment for renal lithiasis.
format	Article
author	Yuliana, Nancy Dewi Khatib, Alfi Link-Struensee, Anne Maria Regina Ijzerman, Adriaan P. Rungkat-Zakaria, Fransiska Choi, Young Hae Verpoorte, Robert
author_facet	Yuliana, Nancy Dewi Khatib, Alfi Link-Struensee, Anne Maria Regina Ijzerman, Adriaan P. Rungkat-Zakaria, Fransiska Choi, Young Hae Verpoorte, Robert
author_sort	Yuliana, Nancy Dewi
title	Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
title_short	Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
title_full	Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
title_fullStr	Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
title_full_unstemmed	Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
title_sort	adenosine a1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus
publisher	Thieme Verlagsgruppe
publishDate	2009
url	http://irep.iium.edu.my/33741/ http://irep.iium.edu.my/33741/ http://irep.iium.edu.my/33741/ http://irep.iium.edu.my/33741/1/Yuliana_et_al._2009.pdf
first_indexed	2023-09-18T20:48:48Z
last_indexed	2023-09-18T20:48:48Z
_version_	1777409854902632448

Adenosine A1 receptor binding activity of methoxy flavonoids from orthosiphon stamineus

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