Effect of some antimalarial drugs on the liver: biochemical and histopathological studies
The effect of antimalarial drugs (Chloroquine, Quinine and Artemisinin on the liver has been investigated in 126 male albino rats. The animals were divided into 3 groups of 42 rats each of 36 experimental and 6 control rats. The 1st group treated with Chloroquine (10mg/ Kg/day); the 2nd group treate...
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2013
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| Online Access: | http://irep.iium.edu.my/33509/ http://irep.iium.edu.my/33509/1/Effect_of_some_antimalarial_drugs.pdf |
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iium-335092015-12-18T02:39:33Z http://irep.iium.edu.my/33509/ Effect of some antimalarial drugs on the liver: biochemical and histopathological studies Al-Ani, Imad Matloub Dally Al-Janabi, Sabaa T. Hamoudi, Salem R. QL Zoology QM Human anatomy QP Physiology RA0421 Public health. Hygiene. Preventive Medicine RB Pathology RM300 Drugs and their action The effect of antimalarial drugs (Chloroquine, Quinine and Artemisinin on the liver has been investigated in 126 male albino rats. The animals were divided into 3 groups of 42 rats each of 36 experimental and 6 control rats. The 1st group treated with Chloroquine (10mg/ Kg/day); the 2nd group treated with Quinine (30mg/ Kg/day) and the 3rd group treated with Artemisinin (8mg/ Kg/day). Quinine and Artemisinin were injected intramuscularly, while Chloroquine was injected intraperitoneally for 14 day. The treated animals, were sacrificed after slight anaesthesia at the 1st, 4th, 6th, 9th, 12th and the 14th day. Blood was obtained from the rat tail vein after a mild prick; liver specimens were fixed in Bouin’s fixative and processed for light microscopy. The result indicated that all the used drugs causes significant increase in the activity of GOT; GPT; ACP; ACP; ALP, LDA activities with corresponding decrease in cholesterol level, total protein and blood glucose. Examination for liver sections revealed definite histological alteration in the hepatic tissue such as necrosis and degeneration of hepatocytes, congestion of the central vein, and vacuolization of cytoplasm, infiltration of inflammatory cells, dilatation and congestion of the blood sinusoids and fatty infiltration. 2013-04 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/33509/1/Effect_of_some_antimalarial_drugs.pdf Al-Ani, Imad Matloub Dally and Al-Janabi, Sabaa T. and Hamoudi, Salem R. (2013) Effect of some antimalarial drugs on the liver: biochemical and histopathological studies. In: International Malaria Symposium 2013, 16-17 April 2013, Kota Kinabalu, Sabah. |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
QL Zoology QM Human anatomy QP Physiology RA0421 Public health. Hygiene. Preventive Medicine RB Pathology RM300 Drugs and their action |
| spellingShingle |
QL Zoology QM Human anatomy QP Physiology RA0421 Public health. Hygiene. Preventive Medicine RB Pathology RM300 Drugs and their action Al-Ani, Imad Matloub Dally Al-Janabi, Sabaa T. Hamoudi, Salem R. Effect of some antimalarial drugs on the liver: biochemical and histopathological studies |
| description |
The effect of antimalarial drugs (Chloroquine, Quinine and Artemisinin on the liver has been investigated in 126 male albino rats. The animals were divided into 3 groups of 42 rats each of 36 experimental and 6 control rats. The 1st group treated with Chloroquine (10mg/ Kg/day); the 2nd group treated with Quinine (30mg/ Kg/day) and the 3rd group treated with Artemisinin (8mg/ Kg/day).
Quinine and Artemisinin were injected intramuscularly, while Chloroquine was injected intraperitoneally for 14 day. The treated animals, were sacrificed after slight anaesthesia at the 1st, 4th, 6th, 9th, 12th and the 14th day. Blood was obtained from the rat tail vein after a mild prick; liver specimens were fixed in Bouin’s fixative and processed for light microscopy.
The result indicated that all the used drugs causes significant increase in the activity of GOT; GPT; ACP; ACP; ALP, LDA activities with corresponding decrease in cholesterol level, total protein and blood glucose.
Examination for liver sections revealed definite histological alteration in the hepatic tissue such as necrosis and degeneration of hepatocytes, congestion of the central vein, and vacuolization of cytoplasm, infiltration of inflammatory cells, dilatation and congestion of the blood sinusoids and fatty infiltration.
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| format |
Conference or Workshop Item |
| author |
Al-Ani, Imad Matloub Dally Al-Janabi, Sabaa T. Hamoudi, Salem R. |
| author_facet |
Al-Ani, Imad Matloub Dally Al-Janabi, Sabaa T. Hamoudi, Salem R. |
| author_sort |
Al-Ani, Imad Matloub Dally |
| title |
Effect of some antimalarial drugs on the liver: biochemical and histopathological studies |
| title_short |
Effect of some antimalarial drugs on the liver: biochemical and histopathological studies |
| title_full |
Effect of some antimalarial drugs on the liver: biochemical and histopathological studies |
| title_fullStr |
Effect of some antimalarial drugs on the liver: biochemical and histopathological studies |
| title_full_unstemmed |
Effect of some antimalarial drugs on the liver: biochemical and histopathological studies |
| title_sort |
effect of some antimalarial drugs on the liver: biochemical and histopathological studies |
| publishDate |
2013 |
| url |
http://irep.iium.edu.my/33509/ http://irep.iium.edu.my/33509/1/Effect_of_some_antimalarial_drugs.pdf |
| first_indexed |
2023-09-18T20:48:26Z |
| last_indexed |
2023-09-18T20:48:26Z |
| _version_ |
1777409832338325504 |