Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease

Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia. We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD. Methods: This is a cross-sectional study involving...

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Main Authors:	Hashim, Hasnur Zaman, Mohamed Ibrahim, Norlinah, Wan Yahya, Nafisah, Tan, Huijan, Raymond, Azman Ali, Tamil, Azmi Mohd
Format:	Article
Language:	English English English
Published:	Informa Healthcare 2014
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://irep.iium.edu.my/32386/ http://irep.iium.edu.my/32386/ http://irep.iium.edu.my/32386/ http://irep.iium.edu.my/32386/1/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced.pdf http://irep.iium.edu.my/32386/2/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_SCOPUS.pdf http://irep.iium.edu.my/32386/3/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_WOS.pdf

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spelling	iium-323862017-09-27T04:39:43Z http://irep.iium.edu.my/32386/ Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease Hashim, Hasnur Zaman Mohamed Ibrahim, Norlinah Wan Yahya, Nafisah Tan, Huijan Raymond, Azman Ali Tamil, Azmi Mohd RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia. We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD. Methods: This is a cross-sectional study involving 95 patients with PD on uninterrupted levodopa therapy for at least 6 months. The instrument used was the UPDRS questionnaires. The predictors of dyskinesia were determined using multivariate logistic regression analysis. Results: The mean age was 65.6 ± 8.5 years. The mean onset age was 58.5 ± 9.8 years. The median disease duration was 6 (7) years. Dyskinesia was present in 44% (n = 42) with median levodopa therapy of 3 years. There were 64.3% Chinese, 31% Malays, and 3.7% Indians and other ethnic groups. Eighty-one percent of patients with dyskinesia had clinical fluctuations. Patients with dyskinesia had lower onset age ( p < 0.001), longer duration of levodopa therapy ( p < 0.001), longer disease duration ( p < 0.001), higher total daily levodopa dose ( p < 0.001), and higher total UPDRS scores ( p = 0.005) than patients without dyskinesia. The three significant predictors of dyskinesia were duration of levodopa therapy, onset age, and total daily levodopa dose. Conclusions: The prevalence of levodopa-induced dyskinesia in our patients was 44%. The most significant predictors were duration of levodopa therapy, total daily levodopa dose, and onset age. Informa Healthcare 2014-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/32386/1/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced.pdf application/pdf en http://irep.iium.edu.my/32386/2/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/32386/3/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_WOS.pdf Hashim, Hasnur Zaman and Mohamed Ibrahim, Norlinah and Wan Yahya, Nafisah and Tan, Huijan and Raymond, Azman Ali and Tamil, Azmi Mohd (2014) Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease. International Journal of Neuroscience, 124 (3). pp. 187-191. ISSN 0020-7454 http://dx.doi.org/10.3109/00207454.2013.833511 10.3109/00207454.2013.833511
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Hashim, Hasnur Zaman Mohamed Ibrahim, Norlinah Wan Yahya, Nafisah Tan, Huijan Raymond, Azman Ali Tamil, Azmi Mohd Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
description	Chronic pulsatile levodopa therapy for Parkinson's disease (PD) leads to the development of motor fluctuations and dyskinesia. We studied the prevalence and predictors of levodopa-induced dyskinesia among multiethnic Malaysian patients with PD. Methods: This is a cross-sectional study involving 95 patients with PD on uninterrupted levodopa therapy for at least 6 months. The instrument used was the UPDRS questionnaires. The predictors of dyskinesia were determined using multivariate logistic regression analysis. Results: The mean age was 65.6 ± 8.5 years. The mean onset age was 58.5 ± 9.8 years. The median disease duration was 6 (7) years. Dyskinesia was present in 44% (n = 42) with median levodopa therapy of 3 years. There were 64.3% Chinese, 31% Malays, and 3.7% Indians and other ethnic groups. Eighty-one percent of patients with dyskinesia had clinical fluctuations. Patients with dyskinesia had lower onset age ( p < 0.001), longer duration of levodopa therapy ( p < 0.001), longer disease duration ( p < 0.001), higher total daily levodopa dose ( p < 0.001), and higher total UPDRS scores ( p = 0.005) than patients without dyskinesia. The three significant predictors of dyskinesia were duration of levodopa therapy, onset age, and total daily levodopa dose. Conclusions: The prevalence of levodopa-induced dyskinesia in our patients was 44%. The most significant predictors were duration of levodopa therapy, total daily levodopa dose, and onset age.
format	Article
author	Hashim, Hasnur Zaman Mohamed Ibrahim, Norlinah Wan Yahya, Nafisah Tan, Huijan Raymond, Azman Ali Tamil, Azmi Mohd
author_facet	Hashim, Hasnur Zaman Mohamed Ibrahim, Norlinah Wan Yahya, Nafisah Tan, Huijan Raymond, Azman Ali Tamil, Azmi Mohd
author_sort	Hashim, Hasnur Zaman
title	Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_short	Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_full	Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_fullStr	Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_full_unstemmed	Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease
title_sort	risk factors and predictors of levodopa-induced dyskinesia among multiethnic malaysians with parkinson's disease
publisher	Informa Healthcare
publishDate	2014
url	http://irep.iium.edu.my/32386/ http://irep.iium.edu.my/32386/ http://irep.iium.edu.my/32386/ http://irep.iium.edu.my/32386/1/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced.pdf http://irep.iium.edu.my/32386/2/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_SCOPUS.pdf http://irep.iium.edu.my/32386/3/32386_Risk%20factors%20and%20predictors%20of%20levodopa-induced_WOS.pdf
first_indexed	2023-09-18T20:46:45Z
last_indexed	2023-09-18T20:46:45Z
_version_	1777409725700243456

Risk factors and predictors of levodopa-induced dyskinesia among multiethnic Malaysians with Parkinson's disease

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