Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review

Objectives: To determine maternal morbidities in relation to prenatal diagnosis of lethal fetal anomalies and termination of pregnancy (TOP). Materials: Twenty five patients with prenatal diagnosis of lethal fetal anomalies in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia. Methods: This wa...

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Main Authors:	Abdulwahab, Dalia F, S.L., Yong, Ismail, Hamizah, Awang, Mokhtar, Nusee, Zalina, Ismail, Rozihan
Format:	Article
Language:	English English
Published:	Elsevier BV 2012
Subjects:	RG Gynecology and obstetrics
Online Access:	http://irep.iium.edu.my/32311/ http://irep.iium.edu.my/32311/1/FIGO_publicatio.pdf http://irep.iium.edu.my/32311/4/ScienceDirect_-_Search_Results__AUTHORS%28D_Abdulwahab%29.htm

id	iium-32311
recordtype	eprints
spelling	iium-323112014-11-27T08:26:47Z http://irep.iium.edu.my/32311/ Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review Abdulwahab, Dalia F S.L., Yong Ismail, Hamizah Awang, Mokhtar Nusee, Zalina Ismail, Rozihan RG Gynecology and obstetrics Objectives: To determine maternal morbidities in relation to prenatal diagnosis of lethal fetal anomalies and termination of pregnancy (TOP). Materials: Twenty five patients with prenatal diagnosis of lethal fetal anomalies in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia. Methods: This was a retrospective review in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia in the year of 2011. All patients diagnosed prenatally to carry lethal fetal anomalies was reviewed. Data regarding maternal morbidities and outcome was collected from patients’ case note in the hospital record office. Analysis was done by using SPSS version 17.0. Results: Twenty five pregnant patients were diagnosed with lethal fetal anomalies via ultrasound with or without genetic study. The patients’ mean age was 29.9±6.3 years old. The mean gestational age at diagnosis of lethal fetal anomalies and at TOP or delivery were 26.5±7.4 and 28.7±7.8 weeks respectively. The lethal fetal anomalies included fetuses with multiple structural abnormalities (40%), anencephaly or severe encephalocele (32%), non-immune hydrops fetalis (16%) and syndromic fetuses (12%) i.e. Pentalogy of Cantrell and Edward’s syndrome. Seven (28%) patients had early counseling and TOP at the gestation of <22 weeks. Beyond 22 weeks gestation, 8 (32%) patients had TOP and 10 (40%) patients had spontaneous delivery. Twenty (80%) patients delivered or aborted vaginally, 3 (12%) patients with assisted breech delivery, and 2 (8%) patients with abdominal delivery. The abdominal deliveries were for transverse lie in labour and emergency hysterotomy for failed induction complicated by hysterectomy due to intraoperative finding of ruptured uterus. Overall, the associated adverse events included abnormal lie during delivery (16%), symptomatic polyhydramnios requiring amnioreduction (16%), post-partum haemorrhage (12%), retained placenta (12%), blood transfusion (8%), uterine rupture (4%) and endometritis (4%). Mean duration of hospital stay was 6.6±3.7 days. Conclusions: Prenatal diagnosis and TOP at an early gestation may reduce maternal morbidities and improve the outcome Elsevier BV 2012 Article PeerReviewed application/pdf en http://irep.iium.edu.my/32311/1/FIGO_publicatio.pdf application/pdf en http://irep.iium.edu.my/32311/4/ScienceDirect_-_Search_Results__AUTHORS%28D_Abdulwahab%29.htm Abdulwahab, Dalia F and S.L., Yong and Ismail, Hamizah and Awang, Mokhtar and Nusee, Zalina and Ismail, Rozihan (2012) Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review. International Journal of Gynecology and Obstetrics, 119 (3). S713-S713. ISSN 0020-7292
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English
topic	RG Gynecology and obstetrics
spellingShingle	RG Gynecology and obstetrics Abdulwahab, Dalia F S.L., Yong Ismail, Hamizah Awang, Mokhtar Nusee, Zalina Ismail, Rozihan Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review
description	Objectives: To determine maternal morbidities in relation to prenatal diagnosis of lethal fetal anomalies and termination of pregnancy (TOP). Materials: Twenty five patients with prenatal diagnosis of lethal fetal anomalies in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia. Methods: This was a retrospective review in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia in the year of 2011. All patients diagnosed prenatally to carry lethal fetal anomalies was reviewed. Data regarding maternal morbidities and outcome was collected from patients’ case note in the hospital record office. Analysis was done by using SPSS version 17.0. Results: Twenty five pregnant patients were diagnosed with lethal fetal anomalies via ultrasound with or without genetic study. The patients’ mean age was 29.9±6.3 years old. The mean gestational age at diagnosis of lethal fetal anomalies and at TOP or delivery were 26.5±7.4 and 28.7±7.8 weeks respectively. The lethal fetal anomalies included fetuses with multiple structural abnormalities (40%), anencephaly or severe encephalocele (32%), non-immune hydrops fetalis (16%) and syndromic fetuses (12%) i.e. Pentalogy of Cantrell and Edward’s syndrome. Seven (28%) patients had early counseling and TOP at the gestation of <22 weeks. Beyond 22 weeks gestation, 8 (32%) patients had TOP and 10 (40%) patients had spontaneous delivery. Twenty (80%) patients delivered or aborted vaginally, 3 (12%) patients with assisted breech delivery, and 2 (8%) patients with abdominal delivery. The abdominal deliveries were for transverse lie in labour and emergency hysterotomy for failed induction complicated by hysterectomy due to intraoperative finding of ruptured uterus. Overall, the associated adverse events included abnormal lie during delivery (16%), symptomatic polyhydramnios requiring amnioreduction (16%), post-partum haemorrhage (12%), retained placenta (12%), blood transfusion (8%), uterine rupture (4%) and endometritis (4%). Mean duration of hospital stay was 6.6±3.7 days. Conclusions: Prenatal diagnosis and TOP at an early gestation may reduce maternal morbidities and improve the outcome
format	Article
author	Abdulwahab, Dalia F S.L., Yong Ismail, Hamizah Awang, Mokhtar Nusee, Zalina Ismail, Rozihan
author_facet	Abdulwahab, Dalia F S.L., Yong Ismail, Hamizah Awang, Mokhtar Nusee, Zalina Ismail, Rozihan
author_sort	Abdulwahab, Dalia F
title	Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review
title_short	Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review
title_full	Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review
title_fullStr	Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review
title_full_unstemmed	Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review
title_sort	maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review
publisher	Elsevier BV
publishDate	2012
url	http://irep.iium.edu.my/32311/ http://irep.iium.edu.my/32311/1/FIGO_publicatio.pdf http://irep.iium.edu.my/32311/4/ScienceDirect_-_Search_Results__AUTHORS%28D_Abdulwahab%29.htm
first_indexed	2023-09-18T20:46:39Z
last_indexed	2023-09-18T20:46:39Z
_version_	1777409719377330176

Maternal outcome of prenatally diagnosed lethal fetal anomalies: a year review

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