In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts

Diabetes is a chronic common disease, prevalence of diabetes is increasing worldwide; this urges the need for more new treatment. Inhibition of intestinal alpha-amylase and alpha-glucosidase is an improtant strategy to control post-prandial hyperglycemia associated with type 2 diabetes mellitus. Bas...

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Main Authors:	Ahmed, Afnan Sh., Saxena, Anil Kumar, Ahmed, Qamar Uddin, Jamal, Parveen
Format:	Conference or Workshop Item
Language:	English English English
Published:	2012
Subjects:	R Medicine (General) RC Internal medicine RV Botanic, Thomsonian, and eclectic medicine
Online Access:	http://irep.iium.edu.my/32195/ http://irep.iium.edu.my/32195/ http://irep.iium.edu.my/32195/1/Conf._Abstract_Diabetes_Asia_2012.pdf http://irep.iium.edu.my/32195/6/PosterPresentations._Afnan%2BAKS_2013.pdf http://irep.iium.edu.my/32195/11/MSPP.jpg

id	iium-32195
recordtype	eprints
spelling	iium-321952015-07-31T00:23:23Z http://irep.iium.edu.my/32195/ In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts Ahmed, Afnan Sh. Saxena, Anil Kumar Ahmed, Qamar Uddin Jamal, Parveen R Medicine (General) RC Internal medicine RV Botanic, Thomsonian, and eclectic medicine Diabetes is a chronic common disease, prevalence of diabetes is increasing worldwide; this urges the need for more new treatment. Inhibition of intestinal alpha-amylase and alpha-glucosidase is an improtant strategy to control post-prandial hyperglycemia associated with type 2 diabetes mellitus. Based on the fact that plants have been the basis for the treatment of several diseases, Elettaria cardamomum L. (cardamom) has been selected for this study. It has been used traditionally to treat diabetes in Pakistan. Antioxidants present in plants can prevent the development of diabetes; hence, measurement of antioxidant activity of plants will also be carried out. The dried cardamom was extracted and dried extracts of the plant were examined for the alpha-glicosidase inhibition and pancreatic alpha-amylase inhibition. Extracts further quantified with respect to the total phenolic and flavonoid content. Our in vitro studies demonstrated a very good alpha-amylase inhibition %10.41 and %13.73 for water and methanolic extracts respectively. The total phenolic content (TPC) of the dried extracts were 11.99 and 6.46 mg GAE/g for water and methanolic extracts respectively. The total flavonoid content (TFC) is 21.02 and 20.55 QE/g for water and methanolic extracts respectively. We might say that our result can further support the view that some medicinal plants are promising sources of natural antidiabetic and antioxidants. These result support the use of this plant as a munching dietary supplement for the treatment of diabetes, and are first time report on the potential alpha-glicosidase and alpha-amylase inhibition in its activity. 2012-10-17 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/32195/1/Conf._Abstract_Diabetes_Asia_2012.pdf application/pdf en http://irep.iium.edu.my/32195/6/PosterPresentations._Afnan%2BAKS_2013.pdf application/pdf en http://irep.iium.edu.my/32195/11/MSPP.jpg Ahmed, Afnan Sh. and Saxena, Anil Kumar and Ahmed, Qamar Uddin and Jamal, Parveen (2012) In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts. In: Diabetes Asia 20112 Conference & Workshop, 17-21 October 2012, Hotel Istana, Kuala Lumpur, MALAYSIA. (Unpublished) http://www.iium.edu.com
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General) RC Internal medicine RV Botanic, Thomsonian, and eclectic medicine
spellingShingle	R Medicine (General) RC Internal medicine RV Botanic, Thomsonian, and eclectic medicine Ahmed, Afnan Sh. Saxena, Anil Kumar Ahmed, Qamar Uddin Jamal, Parveen In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts
description	Diabetes is a chronic common disease, prevalence of diabetes is increasing worldwide; this urges the need for more new treatment. Inhibition of intestinal alpha-amylase and alpha-glucosidase is an improtant strategy to control post-prandial hyperglycemia associated with type 2 diabetes mellitus. Based on the fact that plants have been the basis for the treatment of several diseases, Elettaria cardamomum L. (cardamom) has been selected for this study. It has been used traditionally to treat diabetes in Pakistan. Antioxidants present in plants can prevent the development of diabetes; hence, measurement of antioxidant activity of plants will also be carried out. The dried cardamom was extracted and dried extracts of the plant were examined for the alpha-glicosidase inhibition and pancreatic alpha-amylase inhibition. Extracts further quantified with respect to the total phenolic and flavonoid content. Our in vitro studies demonstrated a very good alpha-amylase inhibition %10.41 and %13.73 for water and methanolic extracts respectively. The total phenolic content (TPC) of the dried extracts were 11.99 and 6.46 mg GAE/g for water and methanolic extracts respectively. The total flavonoid content (TFC) is 21.02 and 20.55 QE/g for water and methanolic extracts respectively. We might say that our result can further support the view that some medicinal plants are promising sources of natural antidiabetic and antioxidants. These result support the use of this plant as a munching dietary supplement for the treatment of diabetes, and are first time report on the potential alpha-glicosidase and alpha-amylase inhibition in its activity.
format	Conference or Workshop Item
author	Ahmed, Afnan Sh. Saxena, Anil Kumar Ahmed, Qamar Uddin Jamal, Parveen
author_facet	Ahmed, Afnan Sh. Saxena, Anil Kumar Ahmed, Qamar Uddin Jamal, Parveen
author_sort	Ahmed, Afnan Sh.
title	In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts
title_short	In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts
title_full	In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts
title_fullStr	In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts
title_full_unstemmed	In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts
title_sort	in vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. water and methanolic extracts
publishDate	2012
url	http://irep.iium.edu.my/32195/ http://irep.iium.edu.my/32195/ http://irep.iium.edu.my/32195/1/Conf._Abstract_Diabetes_Asia_2012.pdf http://irep.iium.edu.my/32195/6/PosterPresentations._Afnan%2BAKS_2013.pdf http://irep.iium.edu.my/32195/11/MSPP.jpg
first_indexed	2023-09-18T20:46:28Z
last_indexed	2023-09-18T20:46:28Z
_version_	1777409707971969024

In vitro antihyperglycemic and antioxidant potential of elettaria cardamomum l. Water and methanolic extracts

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