Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat

Mangosteen (Garcinia mangostana Linn.) fruit hull has been proven for many years as traditional treatment for skin infection, wounds and inflammatory diseases diabetes?. The study is aimed to investigate hypoglycaemic activity of Methanolic extract of Garcinia mangostana Linn. pericarp (GME) in str...

Full description

Bibliographic Details
Main Authors:	Tg Zakaria, Tg Muhammad Faris Syafiq, Bakhtiar, M. Taher
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/32018/ http://irep.iium.edu.my/32018/ http://irep.iium.edu.my/32018/1/Hypoglycaemic.pdf

id	iium-32018
recordtype	eprints
spelling	iium-320182014-12-09T01:02:45Z http://irep.iium.edu.my/32018/ Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher RS Pharmacy and materia medica Mangosteen (Garcinia mangostana Linn.) fruit hull has been proven for many years as traditional treatment for skin infection, wounds and inflammatory diseases diabetes?. The study is aimed to investigate hypoglycaemic activity of Methanolic extract of Garcinia mangostana Linn. pericarp (GME) in streptozotocin-induced (STZ) diabetic rats. Oral administration of GME at doses of 50, 100 and 200mg/kg b.w. were given to STZ-induced diabetic rats and normoglycaemic rats. The screening of blood glucose level were assessed in single-dose (acute) and multiple-dose study (sub-acute). The serum biochemical parameters and histopathological alterations were examined and compared to reference standard hypoglycamic drug, glibenclamide. The toxicity study indicated safe usage of the extract indicated by……. The result showed a significant reduction of glucose level in GME with doses of 100mg/kg (p<0.001) and 200mg/kg (p<0.05) compared to 50mg/kg. Total cholesterol, serum triglyceride, urea and creatinine were reduced in the treatment group while total protein contents were increased. Histological assessment revealed a mild regenerative activity of β-cell in diabetic rats evidence?. The experimental results indicated that GME exhibited a potent anti-hyperglycaemic activity when compared to control (significany?). Thus, it could be a potential natural source for diabetic management. 2013 Conference or Workshop Item NonPeerReviewed application/pdf en http://irep.iium.edu.my/32018/1/Hypoglycaemic.pdf Tg Zakaria, Tg Muhammad Faris Syafiq and Bakhtiar, M. Taher (2013) Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat. In: 27th Scientific Meeting of Malaysian Society of Pharmacology and Physiology (MSPP2013), 6-8 September 2013, MS Garden Kuantan. http://www.mspp2013.com
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat
description	Mangosteen (Garcinia mangostana Linn.) fruit hull has been proven for many years as traditional treatment for skin infection, wounds and inflammatory diseases diabetes?. The study is aimed to investigate hypoglycaemic activity of Methanolic extract of Garcinia mangostana Linn. pericarp (GME) in streptozotocin-induced (STZ) diabetic rats. Oral administration of GME at doses of 50, 100 and 200mg/kg b.w. were given to STZ-induced diabetic rats and normoglycaemic rats. The screening of blood glucose level were assessed in single-dose (acute) and multiple-dose study (sub-acute). The serum biochemical parameters and histopathological alterations were examined and compared to reference standard hypoglycamic drug, glibenclamide. The toxicity study indicated safe usage of the extract indicated by……. The result showed a significant reduction of glucose level in GME with doses of 100mg/kg (p<0.001) and 200mg/kg (p<0.05) compared to 50mg/kg. Total cholesterol, serum triglyceride, urea and creatinine were reduced in the treatment group while total protein contents were increased. Histological assessment revealed a mild regenerative activity of β-cell in diabetic rats evidence?. The experimental results indicated that GME exhibited a potent anti-hyperglycaemic activity when compared to control (significany?). Thus, it could be a potential natural source for diabetic management.
format	Conference or Workshop Item
author	Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher
author_facet	Tg Zakaria, Tg Muhammad Faris Syafiq Bakhtiar, M. Taher
author_sort	Tg Zakaria, Tg Muhammad Faris Syafiq
title	Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat
title_short	Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat
title_full	Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat
title_fullStr	Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat
title_full_unstemmed	Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat
title_sort	hypoglycaemic activity of ethanolic extract of garcinia mangostana linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat
publishDate	2013
url	http://irep.iium.edu.my/32018/ http://irep.iium.edu.my/32018/ http://irep.iium.edu.my/32018/1/Hypoglycaemic.pdf
first_indexed	2023-09-18T20:46:12Z
last_indexed	2023-09-18T20:46:12Z
_version_	1777409691023835136

Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. pericarp in normoglycaemic and streptozotocyn-induced diabetic rat

Similar Items