Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol

Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral...

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Main Authors:	Chatterjee, Bappaditya, Pal, Tapan
Format:	Article
Language:	English
Published:	International Journal of Pharmaceutical Sciences and Research (IJPSR) 2010
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/31898/ http://irep.iium.edu.my/31898/ http://irep.iium.edu.my/31898/1/Paper1.pdf

id	iium-31898
recordtype	eprints
spelling	iium-318982013-09-19T08:59:59Z http://irep.iium.edu.my/31898/ Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol Chatterjee, Bappaditya Pal, Tapan R Medicine (General) Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dissolution rate. The purpose of the present study is to design a sustained release matrix tablet containing micronized carvedilol phosphate. Phospahte salt of carvedilol possesses better aqueous solubility than it’s free base. Hydroxy propyl substituted β cyclodextrin and poly ethylene oxide are used as release modifying polymer to develop the matrix tablet. The comparative in vitro evaluation between the developed micronized sustained release and non-micronized sustained release matrix tablet of carvedilol are done. A significant increase in in vitro drug release rate is observed in case of the micronized product over the non micronized one. The sustained release matrix tablet of micronized carvedilol may be used as a once daily formulation after relevant pharmacokinetic studies. International Journal of Pharmaceutical Sciences and Research (IJPSR) 2010 Article PeerReviewed application/pdf en http://irep.iium.edu.my/31898/1/Paper1.pdf Chatterjee, Bappaditya and Pal, Tapan (2010) Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol. International Journal of Pharmaceutical Science Research, 10 (1). pp. 96-102. ISSN 0975-8232 http://www.ijpsr.com/V1I10/index.html
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Chatterjee, Bappaditya Pal, Tapan Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol
description	Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dissolution rate. The purpose of the present study is to design a sustained release matrix tablet containing micronized carvedilol phosphate. Phospahte salt of carvedilol possesses better aqueous solubility than it’s free base. Hydroxy propyl substituted β cyclodextrin and poly ethylene oxide are used as release modifying polymer to develop the matrix tablet. The comparative in vitro evaluation between the developed micronized sustained release and non-micronized sustained release matrix tablet of carvedilol are done. A significant increase in in vitro drug release rate is observed in case of the micronized product over the non micronized one. The sustained release matrix tablet of micronized carvedilol may be used as a once daily formulation after relevant pharmacokinetic studies.
format	Article
author	Chatterjee, Bappaditya Pal, Tapan
author_facet	Chatterjee, Bappaditya Pal, Tapan
author_sort	Chatterjee, Bappaditya
title	Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol
title_short	Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol
title_full	Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol
title_fullStr	Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol
title_full_unstemmed	Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol
title_sort	development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol
publisher	International Journal of Pharmaceutical Sciences and Research (IJPSR)
publishDate	2010
url	http://irep.iium.edu.my/31898/ http://irep.iium.edu.my/31898/ http://irep.iium.edu.my/31898/1/Paper1.pdf
first_indexed	2023-09-18T20:46:03Z
last_indexed	2023-09-18T20:46:03Z
_version_	1777409681947361280

Development and in vitro evaluation of micronized sustained release matrix tablet of carvedilol

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