Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis

Breast cancer is the most common malignant tumour & the leading cause of cancer death in women worldwide annually. Invasive duct carcinoma of the breast is a clinically and biologically heterogeneous disease. A cross–sectional study was carried out among 40 cases of formalin fixed, paraffin embe...

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Main Authors:	Aung, Sanda, Aung, Tha
Format:	Conference or Workshop Item
Language:	English
Published:	2013
Subjects:	RB Pathology
Online Access:	http://irep.iium.edu.my/31897/ http://irep.iium.edu.my/31897/ http://irep.iium.edu.my/31897/1/1568.pdf_print.pdf

id	iium-31897
recordtype	eprints
spelling	iium-318972013-09-13T01:54:28Z http://irep.iium.edu.my/31897/ Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis Aung, Sanda Aung, Tha RB Pathology Breast cancer is the most common malignant tumour & the leading cause of cancer death in women worldwide annually. Invasive duct carcinoma of the breast is a clinically and biologically heterogeneous disease. A cross–sectional study was carried out among 40 cases of formalin fixed, paraffin embedded tissue sections of invasive duct carcinoma (NST) of the breast. Histological grading was done according to Modified Bloom and Richardson Grading. Immunoexpression of cyclinD1 (using DAKO M7155) and ER (using DAKO M7047) were detected by immunohistochemistry. In this study, at least 10% of brown nuclear staining regardless of staining intensity was interpreted as positive. The data was analysed by using chi- square test. (SPSS version 11.5) . In 40 patients, the ages ranged from 34 to 78 years with a mean of 54 years. CyclinD1 expression was detected in 43% (17 of 40) of cases, and was inversely associated with histological grade (p=0.01). ER immunoreactivity was found in 30% (12 of 40) of patients and was inversely associated with histological grade (p=0.021). CyclinD1 immunoreactivity was positively associated with estrogen receptor expression (p=0.043). There was no significant correlation with clinical prognostic parameters of age, menopausal status, tumour size and clinical stage with both prognostic biomarkers. 2013-02-19 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/31897/1/1568.pdf_print.pdf Aung, Sanda and Aung, Tha (2013) Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis. In: IIUM Research, Invention and Innovation Exhibition (IRIIE) 2013, 19-20th February 2013, Cultural Activity Centre (CAC) and KAED Gallery, IIUM. http://www.iium.edu.my/irie/13/info/IRIIE-2013-Abstact-Category.pdf
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RB Pathology
spellingShingle	RB Pathology Aung, Sanda Aung, Tha Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis
description	Breast cancer is the most common malignant tumour & the leading cause of cancer death in women worldwide annually. Invasive duct carcinoma of the breast is a clinically and biologically heterogeneous disease. A cross–sectional study was carried out among 40 cases of formalin fixed, paraffin embedded tissue sections of invasive duct carcinoma (NST) of the breast. Histological grading was done according to Modified Bloom and Richardson Grading. Immunoexpression of cyclinD1 (using DAKO M7155) and ER (using DAKO M7047) were detected by immunohistochemistry. In this study, at least 10% of brown nuclear staining regardless of staining intensity was interpreted as positive. The data was analysed by using chi- square test. (SPSS version 11.5) . In 40 patients, the ages ranged from 34 to 78 years with a mean of 54 years. CyclinD1 expression was detected in 43% (17 of 40) of cases, and was inversely associated with histological grade (p=0.01). ER immunoreactivity was found in 30% (12 of 40) of patients and was inversely associated with histological grade (p=0.021). CyclinD1 immunoreactivity was positively associated with estrogen receptor expression (p=0.043). There was no significant correlation with clinical prognostic parameters of age, menopausal status, tumour size and clinical stage with both prognostic biomarkers.
format	Conference or Workshop Item
author	Aung, Sanda Aung, Tha
author_facet	Aung, Sanda Aung, Tha
author_sort	Aung, Sanda
title	Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis
title_short	Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis
title_full	Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis
title_fullStr	Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis
title_full_unstemmed	Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis
title_sort	association between prognostic biomarkers of cyclind1 and estrogen receptor in breast cancer by immunohistochemical analysis
publishDate	2013
url	http://irep.iium.edu.my/31897/ http://irep.iium.edu.my/31897/ http://irep.iium.edu.my/31897/1/1568.pdf_print.pdf
first_indexed	2023-09-18T20:46:03Z
last_indexed	2023-09-18T20:46:03Z
_version_	1777409681796366336

Association between prognostic biomarkers of CyclinD1 and estrogen receptor in breast cancer by immunohistochemical analysis

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