Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells

3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is fo...

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Main Authors:	Ghalib, Gaza Murad, Mehdi, Sayed Hasan, Hashim, Rokiah, Sulaiman, Othman, How, Fiona Ni Foong, Ahamed, B. M. Khadeer, Abdul Majid, Amin Malik Shah, Ahmed, Faiyaz
Format:	Article
Language:	English
Published:	Academic Journals 2013
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/31142/ http://irep.iium.edu.my/31142/ http://irep.iium.edu.my/31142/ http://irep.iium.edu.my/31142/1/JMPR_2013.pdf

id	iium-31142
recordtype	eprints
spelling	iium-311422013-08-05T01:58:01Z http://irep.iium.edu.my/31142/ Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz QD Chemistry 3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis. The study suggests that the anti-proliferative property of eupalitin towards the human colorectal tumor cells may be probably due to its capability to induce apoptosis in cells. Academic Journals 2013-05-25 Article PeerReviewed application/pdf en http://irep.iium.edu.my/31142/1/JMPR_2013.pdf Ghalib, Gaza Murad and Mehdi, Sayed Hasan and Hashim, Rokiah and Sulaiman, Othman and How, Fiona Ni Foong and Ahamed, B. M. Khadeer and Abdul Majid, Amin Malik Shah and Ahmed, Faiyaz (2013) Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells. Journal of Medicinal Plants Research, 7 (20). pp. 1401-1405. ISSN 1996-0875 http://www.academicjournals.org/JMPR/abstracts/abstracts/abstracts2013/25May/Ghalib%20et%20al.htm 10.5897/JMPR11.801
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
description	3,5,4′-Trihydroxy-6,7-dimethoxy-flavone (Eupalitin) has been isolated from the leaves of Asparagus falcatus (Linn.). Anti-proliferation and apoptosis studies were conducted on eupalitin. Results showed that eupalitin exhibited significant cytotoxicity against human colorectal tumor cells. It is found that eupalitin induces the activation of caspases 3/7, a hallmark of apoptosis. The study suggests that the anti-proliferative property of eupalitin towards the human colorectal tumor cells may be probably due to its capability to induce apoptosis in cells.
format	Article
author	Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz
author_facet	Ghalib, Gaza Murad Mehdi, Sayed Hasan Hashim, Rokiah Sulaiman, Othman How, Fiona Ni Foong Ahamed, B. M. Khadeer Abdul Majid, Amin Malik Shah Ahmed, Faiyaz
author_sort	Ghalib, Gaza Murad
title	Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
title_short	Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
title_full	Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
title_fullStr	Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
title_full_unstemmed	Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
title_sort	eupalitin from asparagus falcatus (linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells
publisher	Academic Journals
publishDate	2013
url	http://irep.iium.edu.my/31142/ http://irep.iium.edu.my/31142/ http://irep.iium.edu.my/31142/ http://irep.iium.edu.my/31142/1/JMPR_2013.pdf
first_indexed	2023-09-18T20:45:23Z
last_indexed	2023-09-18T20:45:23Z
_version_	1777409640312602624

Eupalitin from Asparagus falcatus (Linn.) has anticancer activity and induces activation of caspases 3/7 in human colorectal tumor cells

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