Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors

OBJECTIVE. Proton MR spectroscopy is a recently described technique with high sensitivity and specificity for differentiating breast carcinoma from benign lesions. We evaluated the possible relationship between spectroscopy results and the tumor proliferative index, angiogenesis, and HER2/neu oncoge...

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Main Authors:	Tse, Gary, Abdul Samad, Humairah, Pang, Lai-Man, Chu, Winnie, Law, Bonita Ka Bo, Kung, Fred Y.L, Yeung, David K.W
Format:	Article
Language:	English
Published:	American Roentgen Ray Society 2003
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/30907/ http://irep.iium.edu.my/30907/1/Characterization_of_Lesions.pdf

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spelling	iium-309072017-06-21T00:33:25Z http://irep.iium.edu.my/30907/ Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors Tse, Gary Abdul Samad, Humairah Pang, Lai-Man Chu, Winnie Law, Bonita Ka Bo Kung, Fred Y.L Yeung, David K.W R Medicine (General) OBJECTIVE. Proton MR spectroscopy is a recently described technique with high sensitivity and specificity for differentiating breast carcinoma from benign lesions. We evaluated the possible relationship between spectroscopy results and the tumor proliferative index, angiogenesis, and HER2/neu oncogene overexpression. SUBJECTS AND METHODS. We prospectively evaluated 19 breast carcinomas, 21 benign breast lesions (including 18 fibroadenomas, one fibrocystic change, one hamartoma, and one papilloma), and six phyllodes tumors (four benign, two of borderline malignancy) using proton MR spectroscopy. All lesions were larger than 1.5 cm. Tumor Ki-67 proliferative index, tumor angiogenesis, and HER2/neu oncogene overexpression were evaluated by immunohistochemistry of the histologic material. RESULTS. Spectroscopy findings were positive in 17 (89%) of 19 carcinomas but negative for all benign lesions and phyllodes tumors (sensitivity, 89%; specificity, 100%). Significantly higher levels were obtained for all biologic parameters in carcinomas compared with benign lesions and phyllodes tumors. HER2/neu oncogene overexpression was present in 37% of carcinomas but not in other lesions. The two false-negative findings of breast carcinoma showed similar Ki-67 proliferative index and microvessel density compared with the remaining carcinomas, but both cases were negative for HER2/neu overexpression. CONCLUSION. Proton MR spectroscopy is useful in the in vivo characterization of breast masses when the lesion exceeds 1.5 cm in maximal dimension. Spectroscopy is unable to reveal benign breast lesions and phyllodes tumors of benign and borderline malignancy. We suggest that a false-negative spectroscopic result may be related to an absence of HER2/neu overexpression in carcinoma of the breast. American Roentgen Ray Society 2003-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/30907/1/Characterization_of_Lesions.pdf Tse, Gary and Abdul Samad, Humairah and Pang, Lai-Man and Chu, Winnie and Law, Bonita Ka Bo and Kung, Fred Y.L and Yeung, David K.W (2003) Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors. American Journal of Roentgenology, 181 (5). pp. 1267-1272. ISSN 0361-803X
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Tse, Gary Abdul Samad, Humairah Pang, Lai-Man Chu, Winnie Law, Bonita Ka Bo Kung, Fred Y.L Yeung, David K.W Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors
description	OBJECTIVE. Proton MR spectroscopy is a recently described technique with high sensitivity and specificity for differentiating breast carcinoma from benign lesions. We evaluated the possible relationship between spectroscopy results and the tumor proliferative index, angiogenesis, and HER2/neu oncogene overexpression. SUBJECTS AND METHODS. We prospectively evaluated 19 breast carcinomas, 21 benign breast lesions (including 18 fibroadenomas, one fibrocystic change, one hamartoma, and one papilloma), and six phyllodes tumors (four benign, two of borderline malignancy) using proton MR spectroscopy. All lesions were larger than 1.5 cm. Tumor Ki-67 proliferative index, tumor angiogenesis, and HER2/neu oncogene overexpression were evaluated by immunohistochemistry of the histologic material. RESULTS. Spectroscopy findings were positive in 17 (89%) of 19 carcinomas but negative for all benign lesions and phyllodes tumors (sensitivity, 89%; specificity, 100%). Significantly higher levels were obtained for all biologic parameters in carcinomas compared with benign lesions and phyllodes tumors. HER2/neu oncogene overexpression was present in 37% of carcinomas but not in other lesions. The two false-negative findings of breast carcinoma showed similar Ki-67 proliferative index and microvessel density compared with the remaining carcinomas, but both cases were negative for HER2/neu overexpression. CONCLUSION. Proton MR spectroscopy is useful in the in vivo characterization of breast masses when the lesion exceeds 1.5 cm in maximal dimension. Spectroscopy is unable to reveal benign breast lesions and phyllodes tumors of benign and borderline malignancy. We suggest that a false-negative spectroscopic result may be related to an absence of HER2/neu overexpression in carcinoma of the breast.
format	Article
author	Tse, Gary Abdul Samad, Humairah Pang, Lai-Man Chu, Winnie Law, Bonita Ka Bo Kung, Fred Y.L Yeung, David K.W
author_facet	Tse, Gary Abdul Samad, Humairah Pang, Lai-Man Chu, Winnie Law, Bonita Ka Bo Kung, Fred Y.L Yeung, David K.W
author_sort	Tse, Gary
title	Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors
title_short	Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors
title_full	Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors
title_fullStr	Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors
title_full_unstemmed	Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors
title_sort	characterization of lesions of the breast with proton mr spectroscopy: comparison of carcinomas, benign lesions, and phyllodes tumors
publisher	American Roentgen Ray Society
publishDate	2003
url	http://irep.iium.edu.my/30907/ http://irep.iium.edu.my/30907/1/Characterization_of_Lesions.pdf
first_indexed	2023-09-18T20:45:08Z
last_indexed	2023-09-18T20:45:08Z
_version_	1777409624564039680

Characterization of lesions of the breast with Proton MR Spectroscopy: Comparison of Carcinomas, Benign Lesions, and Phyllodes Tumors

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