An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract

Inflammation is the complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells, or irritants. In the present investigation an attempt was made to screen the anti-inflammatory activity of Basellaalba leaf. From this study, it can be concluded that, Basellaalba...

Full description

Bibliographic Details
Main Authors:	Abdul Kalam, Azad, Wan Sulaiman, Wan Mohd. Azizi, Z. M., Babar, Labu, Zubair Khalid, Zabin, S.
Format:	Article
Language:	English
Published:	International Digital Organization for Scientific Information (IDOSI) 2013
Subjects:	QD Chemistry QR180 Immunology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine
Online Access:	http://irep.iium.edu.my/30539/ http://irep.iium.edu.my/30539/ http://irep.iium.edu.my/30539/ http://irep.iium.edu.my/30539/1/Azad_MEJSR-Bsella_alba.pdf

id	iium-30539
recordtype	eprints
spelling	iium-305392013-07-01T01:55:11Z http://irep.iium.edu.my/30539/ An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract Abdul Kalam, Azad Wan Sulaiman, Wan Mohd. Azizi Z. M., Babar Labu, Zubair Khalid Zabin, S. QD Chemistry QR180 Immunology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Inflammation is the complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells, or irritants. In the present investigation an attempt was made to screen the anti-inflammatory activity of Basellaalba leaf. From this study, it can be concluded that, Basellaalba possesses a good anti-inflammatory activity. In the cotton pellet induced inflammation and In the carrageenan induced inflammation the animals treated with the plant extract have been shown a significant activity at 500 mg/kg dose (p<0.001) which was comparable with the standard drug. In view of the percentage inhibition also the plant was studied, in which the plant extract was found effective. The antibacterial activity was carried out using different dilutions of methanolic extract against gram positive strains (Staphylococcus aureus, Micrococcus luteus, Bacillus subtilus) and gram negative ones (Pseudomonas aeruginosa) by the cup-plate assay method and minimum inhibitory concentrations (MICs). The different concentrations of extract showed moderate activity against Pseudomonas aeruginosa, Bacillus subtiliswhile weak response against Staphylococcus aureus, Micrococcus luteus and Escherichiacoli. The minimum inhibitory concentration of methanolic extract was 6.25μg/ml against Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa and Bacillussubtilus and 12.5 μg/ml against Escherichia coli. The overall result of this study indicates that the methanolic extract of Basellaalba have interesting anti-inflammatory and antibacterial properties. International Digital Organization for Scientific Information (IDOSI) 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/30539/1/Azad_MEJSR-Bsella_alba.pdf Abdul Kalam, Azad and Wan Sulaiman, Wan Mohd. Azizi and Z. M., Babar and Labu, Zubair Khalid and Zabin, S. (2013) An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract. Middle-East Journal of Scientific Research, 14 (5). pp. 650-655. ISSN 1990-9233 http://www.idosi.org/mejsr/mejsr.htm 10.5829/idosi.mejsr.2013.14.5.71225
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry QR180 Immunology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine
spellingShingle	QD Chemistry QR180 Immunology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Abdul Kalam, Azad Wan Sulaiman, Wan Mohd. Azizi Z. M., Babar Labu, Zubair Khalid Zabin, S. An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
description	Inflammation is the complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells, or irritants. In the present investigation an attempt was made to screen the anti-inflammatory activity of Basellaalba leaf. From this study, it can be concluded that, Basellaalba possesses a good anti-inflammatory activity. In the cotton pellet induced inflammation and In the carrageenan induced inflammation the animals treated with the plant extract have been shown a significant activity at 500 mg/kg dose (p<0.001) which was comparable with the standard drug. In view of the percentage inhibition also the plant was studied, in which the plant extract was found effective. The antibacterial activity was carried out using different dilutions of methanolic extract against gram positive strains (Staphylococcus aureus, Micrococcus luteus, Bacillus subtilus) and gram negative ones (Pseudomonas aeruginosa) by the cup-plate assay method and minimum inhibitory concentrations (MICs). The different concentrations of extract showed moderate activity against Pseudomonas aeruginosa, Bacillus subtiliswhile weak response against Staphylococcus aureus, Micrococcus luteus and Escherichiacoli. The minimum inhibitory concentration of methanolic extract was 6.25μg/ml against Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa and Bacillussubtilus and 12.5 μg/ml against Escherichia coli. The overall result of this study indicates that the methanolic extract of Basellaalba have interesting anti-inflammatory and antibacterial properties.
format	Article
author	Abdul Kalam, Azad Wan Sulaiman, Wan Mohd. Azizi Z. M., Babar Labu, Zubair Khalid Zabin, S.
author_facet	Abdul Kalam, Azad Wan Sulaiman, Wan Mohd. Azizi Z. M., Babar Labu, Zubair Khalid Zabin, S.
author_sort	Abdul Kalam, Azad
title	An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_short	An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_full	An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_fullStr	An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_full_unstemmed	An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_sort	overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
publisher	International Digital Organization for Scientific Information (IDOSI)
publishDate	2013
url	http://irep.iium.edu.my/30539/ http://irep.iium.edu.my/30539/ http://irep.iium.edu.my/30539/ http://irep.iium.edu.my/30539/1/Azad_MEJSR-Bsella_alba.pdf
first_indexed	2023-09-18T20:44:43Z
last_indexed	2023-09-18T20:44:43Z
_version_	1777409598047649792

An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract

Similar Items