$Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats$

Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats

Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats Author(s): Norsidah, KZ (Norsidah, Ku-Zaifah)[ 1 ] ; Asmadi, AY (Asmadi, Ahmad Yusof)[ 2 ] ; Azizi, A (Azizi, Ayob)[ 3 ] ; Faizah, O (Faizah, Othman)[ 4 ] ; Kamisah, Y (Kamisah, Yusof)[ 5 ]...

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Main Authors:	Ku Zaifah, Norsidah, Ayob, Azizi, Yusuf, Ahmad Asmadi, Yusuf, Kamisah, Othman, Faizah
Format:	Article
Language:	English
Published:	Hindawi Publishing 2013
Subjects:	RM214 Diet therapy. Diet and dietectics in disease
Online Access:	http://irep.iium.edu.my/30482/ http://irep.iium.edu.my/30482/ http://irep.iium.edu.my/30482/ http://irep.iium.edu.my/30482/1/HINDAWI_PAPER.pdf

id	iium-30482
recordtype	eprints
spelling	iium-304822015-04-07T02:59:30Z http://irep.iium.edu.my/30482/ Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats Ku Zaifah, Norsidah Ayob, Azizi Yusuf, Ahmad Asmadi Yusuf, Kamisah Othman, Faizah RM214 Diet therapy. Diet and dietectics in disease Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats Author(s): Norsidah, KZ (Norsidah, Ku-Zaifah)[ 1 ] ; Asmadi, AY (Asmadi, Ahmad Yusof)[ 2 ] ; Azizi, A (Azizi, Ayob)[ 3 ] ; Faizah, O (Faizah, Othman)[ 4 ] ; Kamisah, Y (Kamisah, Yusof)[ 5 ] Source: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE Article Number: 976967 DOI: 10.1155/2013/976967 Published: 2013 Times Cited: 0 (from Web of Science) Cited References: 58 [ view related records ] Citation Map Abstract: This study investigated the effects of palm tocotrienol-rich fraction (TRF) on aortic proatherosclerotic changes in rats fed with a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control (fed with a basal diet). Another five groups were fed with 1% methionine diet for 10 weeks. From week 6 onward, folate (8mg/kg diet) or palm TRF (30, 60, and 150mg/kg diets) was added into the diet of the last four rat groups, respectively. The high methionine diet raised the plasma total homocysteine and aortic lipid peroxidation, which were reduced by the palm TRF and folate supplementations. Plasma nitric oxide was reduced in the high methionine group compared to the control (3.72 +/- 0.57 versus 6.65 +/- 0.53 mu mol/L, P < 0.05), which reduction was reversed by the palm TRF (60 and 150mg/kg) and folate supplementations. The increased aortic vascular cell adhesion molecule-1 expression in the methionine group (2.58 +/- 0.29) was significantly reduced by the folate (1.38 +/- 0.18) and palm TRF at 150mg/kg (1.19 +/- 0.23). Palm TRF was comparable to folate in reducing high methionine diet-induced plasma hyperhomocysteinemia, aortic oxidative stress, and inflammatory changes in rats Hindawi Publishing 2013 Article PeerReviewed application/pdf en http://irep.iium.edu.my/30482/1/HINDAWI_PAPER.pdf Ku Zaifah, Norsidah and Ayob, Azizi and Yusuf, Ahmad Asmadi and Yusuf, Kamisah and Othman, Faizah (2013) Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats. Evidence-Based Complementary and Alternative Medicine, 2013 (976967). ISSN 1741-427X http://www.hindawi.com/journals/ecam/2013/976967/ 10.1155/2013/976967
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM214 Diet therapy. Diet and dietectics in disease
spellingShingle	RM214 Diet therapy. Diet and dietectics in disease Ku Zaifah, Norsidah Ayob, Azizi Yusuf, Ahmad Asmadi Yusuf, Kamisah Othman, Faizah Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
description	Palm Tocotrienol-Rich Fraction Improves Vascular Proatherosclerotic Changes in Hyperhomocysteinemic Rats Author(s): Norsidah, KZ (Norsidah, Ku-Zaifah)[ 1 ] ; Asmadi, AY (Asmadi, Ahmad Yusof)[ 2 ] ; Azizi, A (Azizi, Ayob)[ 3 ] ; Faizah, O (Faizah, Othman)[ 4 ] ; Kamisah, Y (Kamisah, Yusof)[ 5 ] Source: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE Article Number: 976967 DOI: 10.1155/2013/976967 Published: 2013 Times Cited: 0 (from Web of Science) Cited References: 58 [ view related records ] Citation Map Abstract: This study investigated the effects of palm tocotrienol-rich fraction (TRF) on aortic proatherosclerotic changes in rats fed with a high methionine diet. Forty-two male Wistar rats were divided into six groups. The first group was the control (fed with a basal diet). Another five groups were fed with 1% methionine diet for 10 weeks. From week 6 onward, folate (8mg/kg diet) or palm TRF (30, 60, and 150mg/kg diets) was added into the diet of the last four rat groups, respectively. The high methionine diet raised the plasma total homocysteine and aortic lipid peroxidation, which were reduced by the palm TRF and folate supplementations. Plasma nitric oxide was reduced in the high methionine group compared to the control (3.72 +/- 0.57 versus 6.65 +/- 0.53 mu mol/L, P < 0.05), which reduction was reversed by the palm TRF (60 and 150mg/kg) and folate supplementations. The increased aortic vascular cell adhesion molecule-1 expression in the methionine group (2.58 +/- 0.29) was significantly reduced by the folate (1.38 +/- 0.18) and palm TRF at 150mg/kg (1.19 +/- 0.23). Palm TRF was comparable to folate in reducing high methionine diet-induced plasma hyperhomocysteinemia, aortic oxidative stress, and inflammatory changes in rats
format	Article
author	Ku Zaifah, Norsidah Ayob, Azizi Yusuf, Ahmad Asmadi Yusuf, Kamisah Othman, Faizah
author_facet	Ku Zaifah, Norsidah Ayob, Azizi Yusuf, Ahmad Asmadi Yusuf, Kamisah Othman, Faizah
author_sort	Ku Zaifah, Norsidah
title	Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
title_short	Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
title_full	Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
title_fullStr	Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
title_full_unstemmed	Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
title_sort	palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats
publisher	Hindawi Publishing
publishDate	2013
url	http://irep.iium.edu.my/30482/ http://irep.iium.edu.my/30482/ http://irep.iium.edu.my/30482/ http://irep.iium.edu.my/30482/1/HINDAWI_PAPER.pdf
first_indexed	2023-09-18T20:44:37Z
last_indexed	2023-09-18T20:44:37Z
_version_	1777409592094883840

Palm tocotrienol-rich fraction improves vascular proatherosclerotic changes in hyperhomocysteinemic rats

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