The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats

Diabetes is a worldwide chronic metabolic disorder which can lead to poor quality of life and even death. Nowadays, herbal therapy is considered as an alternative therapy for diabetes.The aim of this study is to investigate the effect of aqueous extract of Tinospora crispa (TCA) on blood glucose lev...

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Main Authors:	Aung, Nilar, Firdausa, Sarah, Cho, Maung Maung, Maung Maung , Khin, Ku Zaifah, Norsidah
Format:	Conference or Workshop Item
Language:	English English English
Published:	2013
Subjects:	R Medicine (General)
Online Access:	http://irep.iium.edu.my/30088/ http://irep.iium.edu.my/30088/8/IRIIE_poster_2013.pdf http://irep.iium.edu.my/30088/1/ABSTRACT_IRIIE_-_2013_%28_TC%29.pdf http://irep.iium.edu.my/30088/4/6_001%2C_IRIIE%2C_Certificate%2C_13.jpg

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recordtype	eprints
spelling	iium-300882015-04-07T03:26:09Z http://irep.iium.edu.my/30088/ The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats Aung, Nilar Firdausa, Sarah Cho, Maung Maung Maung Maung , Khin Ku Zaifah, Norsidah R Medicine (General) Diabetes is a worldwide chronic metabolic disorder which can lead to poor quality of life and even death. Nowadays, herbal therapy is considered as an alternative therapy for diabetes.The aim of this study is to investigate the effect of aqueous extract of Tinospora crispa (TCA) on blood glucose level and anti-oxidant status in streptozotocin induced diabetic Sprague-Dawley rats. The animals were divided into five groups (n=6), as follows: normal control (N), normal TCA treated (NT), diabetic control (D), diabetic treated with TCA (DT), and diabetic treated with Vitamin E (DE). Treatment was given for four weeks and blood sample were withdrawn for analysis. The data among groups were compared using one way ANOVA test while pair t test was used to analyze the differences between the data at the beginning and end of the experiment. Blood glucose level of diabetic groups (D and DE) significantly increased at the end of the experiment, but there is no significant changed in control (N) and (TCA) treated groups (NT and DT). Body weight of control and TCA treated group increased significantly, however in diabetic group it decreased significantly. Superoxide dismutase enzyme activity was decreased in groups D and DE, that there is no changed in other groups (N, NT and DT). Glutathione peroxidase was even increased in NT and DT groups. Lipid hydroperoxide and isoprostane level increased significantly in D group, however there is no changed in other groups. This showed that TCA not only lowered blood glucose level but also protect the experimental animals from reactive oxygen species by increasing antioxidant enzyme activity and controlling reactive oxygen species. 2013-02-19 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/30088/8/IRIIE_poster_2013.pdf application/pdf en http://irep.iium.edu.my/30088/1/ABSTRACT_IRIIE_-_2013_%28_TC%29.pdf application/pdf en http://irep.iium.edu.my/30088/4/6_001%2C_IRIIE%2C_Certificate%2C_13.jpg Aung, Nilar and Firdausa, Sarah and Cho, Maung Maung and Maung Maung , Khin and Ku Zaifah, Norsidah (2013) The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats. In: IIUM Research, Innovation & Invention Exhibition (IRIIE 2013), 19- 20 February 2010, Kuala Lumpur. (Unpublished)
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English
topic	R Medicine (General)
spellingShingle	R Medicine (General) Aung, Nilar Firdausa, Sarah Cho, Maung Maung Maung Maung , Khin Ku Zaifah, Norsidah The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats
description	Diabetes is a worldwide chronic metabolic disorder which can lead to poor quality of life and even death. Nowadays, herbal therapy is considered as an alternative therapy for diabetes.The aim of this study is to investigate the effect of aqueous extract of Tinospora crispa (TCA) on blood glucose level and anti-oxidant status in streptozotocin induced diabetic Sprague-Dawley rats. The animals were divided into five groups (n=6), as follows: normal control (N), normal TCA treated (NT), diabetic control (D), diabetic treated with TCA (DT), and diabetic treated with Vitamin E (DE). Treatment was given for four weeks and blood sample were withdrawn for analysis. The data among groups were compared using one way ANOVA test while pair t test was used to analyze the differences between the data at the beginning and end of the experiment. Blood glucose level of diabetic groups (D and DE) significantly increased at the end of the experiment, but there is no significant changed in control (N) and (TCA) treated groups (NT and DT). Body weight of control and TCA treated group increased significantly, however in diabetic group it decreased significantly. Superoxide dismutase enzyme activity was decreased in groups D and DE, that there is no changed in other groups (N, NT and DT). Glutathione peroxidase was even increased in NT and DT groups. Lipid hydroperoxide and isoprostane level increased significantly in D group, however there is no changed in other groups. This showed that TCA not only lowered blood glucose level but also protect the experimental animals from reactive oxygen species by increasing antioxidant enzyme activity and controlling reactive oxygen species.
format	Conference or Workshop Item
author	Aung, Nilar Firdausa, Sarah Cho, Maung Maung Maung Maung , Khin Ku Zaifah, Norsidah
author_facet	Aung, Nilar Firdausa, Sarah Cho, Maung Maung Maung Maung , Khin Ku Zaifah, Norsidah
author_sort	Aung, Nilar
title	The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats
title_short	The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats
title_full	The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats
title_fullStr	The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats
title_full_unstemmed	The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats
title_sort	effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats
publishDate	2013
url	http://irep.iium.edu.my/30088/ http://irep.iium.edu.my/30088/8/IRIIE_poster_2013.pdf http://irep.iium.edu.my/30088/1/ABSTRACT_IRIIE_-_2013_%28_TC%29.pdf http://irep.iium.edu.my/30088/4/6_001%2C_IRIIE%2C_Certificate%2C_13.jpg
first_indexed	2023-09-18T20:44:11Z
last_indexed	2023-09-18T20:44:11Z
_version_	1777409564196470784

The effect of tinospora crispa on antioxidant status in streptozotocin induced diabetic rats

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