Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate

A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallogr...

Full description

Bibliographic Details
Main Authors:	Ravoof, Thahira Begum, Crouse, Karen Anne, Tahir, Mohamed Ibrahim Mohamed, Rosli, Rozita, Watkin, David J., How, Fiona Ni Foong
Format:	Article
Language:	English
Published:	SpringerLink 2011
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/300/ http://irep.iium.edu.my/300/ http://irep.iium.edu.my/300/1/jocc_paper.pdf

id	iium-300
recordtype	eprints
spelling	iium-3002012-02-29T06:50:34Z http://irep.iium.edu.my/300/ Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong QD Chemistry A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor). SpringerLink 2011-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/300/1/jocc_paper.pdf Ravoof, Thahira Begum and Crouse, Karen Anne and Tahir, Mohamed Ibrahim Mohamed and Rosli, Rozita and Watkin, David J. and How, Fiona Ni Foong (2011) Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate. Journal of Chemical Crystallography, 41 (4). pp. 491-495. ISSN 1074-1542 10.1007/s10870-010-9907-3
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
description	A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor).
format	Article
author	Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong
author_facet	Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong
author_sort	Ravoof, Thahira Begum
title	Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_short	Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_full	Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_fullStr	Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_full_unstemmed	Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_sort	synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
publisher	SpringerLink
publishDate	2011
url	http://irep.iium.edu.my/300/ http://irep.iium.edu.my/300/ http://irep.iium.edu.my/300/1/jocc_paper.pdf
first_indexed	2023-09-18T20:07:26Z
last_indexed	2023-09-18T20:07:26Z
_version_	1777407252206977024

Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate

Similar Items