TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype

TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype

Presence of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), although this has remained controversial. The TP53 codon 72 polymorphism has shown negative impact on cancer survival, but this has not been analyzed in DLBCL. Furthermore, the MDM2 SNP309...

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Main Authors: Zainuddin, Norafiza, Berglund, Mattias, Wanders, Alkwin, Ren, Zhi-Ping, Amini, Rose-Marie, Lindell, Monica, Kanduri, Meena, Roos, Göran, Rosenquist, Richard, Enblad, Gunilla
Format: Article
Language:English
Published: Elsevier Limited 2008
Subjects:
RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Online Access:http://irep.iium.edu.my/29949/
http://irep.iium.edu.my/29949/
http://irep.iium.edu.my/29949/
http://irep.iium.edu.my/29949/1/Preview_of_%E2%80%9CUntitled_Document%E2%80%9D_tp53.pdf
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spelling iium-299492016-12-08T01:37:18Z http://irep.iium.edu.my/29949/ TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype Zainuddin, Norafiza Berglund, Mattias Wanders, Alkwin Ren, Zhi-Ping Amini, Rose-Marie Lindell, Monica Kanduri, Meena Roos, Göran Rosenquist, Richard Enblad, Gunilla RC0254 Neoplasms. Tumors. Oncology (including Cancer) Presence of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), although this has remained controversial. The TP53 codon 72 polymorphism has shown negative impact on cancer survival, but this has not been analyzed in DLBCL. Furthermore, the MDM2 SNP309 has been associated with earlier age of onset in DLBCL. Here, we investigated the clinical impact of TP53 mutations,MDM2SNP309 and TP53 codon 72 polymorphisms on survival in DLBCL of germinal center (GC) and non-GC subtypes. Thirteen of the 102 (12.7%) patients displayed TP53 mutations. Overall, TP53 mutations had a significant effect on lymphoma-specific survival (LSS, P = 0.009) and progression-free survival (PFS, P = 0.028). In particular, inferior survival was observed in TP53-mutated DLBCLs of GC subtype (LSS, P = 0.002 and PFS, P = 0.006). Neither MDM2 SNP309 nor the TP53 codon 72 polymorphism had an impact on age of onset or survival. Altogether, our data suggests that TP53 mutations are associated with poor outcome in GC-DLBCL patients. Elsevier Limited 2008-08-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/29949/1/Preview_of_%E2%80%9CUntitled_Document%E2%80%9D_tp53.pdf Zainuddin, Norafiza and Berglund, Mattias and Wanders, Alkwin and Ren, Zhi-Ping and Amini, Rose-Marie and Lindell, Monica and Kanduri, Meena and Roos, Göran and Rosenquist, Richard and Enblad, Gunilla (2008) TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype. Leukemia Research, 33. pp. 60-66. ISSN 0145-2126 http://www.lrjournal.com/article/S0145-2126(10)00428-5/abstract doi:10.1016/j.leukres.2008.06.022
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic RC0254 Neoplasms. Tumors. Oncology (including Cancer)
spellingShingle RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Zainuddin, Norafiza
Berglund, Mattias
Wanders, Alkwin
Ren, Zhi-Ping
Amini, Rose-Marie
Lindell, Monica
Kanduri, Meena
Roos, Göran
Rosenquist, Richard
Enblad, Gunilla
TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype
description Presence of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), although this has remained controversial. The TP53 codon 72 polymorphism has shown negative impact on cancer survival, but this has not been analyzed in DLBCL. Furthermore, the MDM2 SNP309 has been associated with earlier age of onset in DLBCL. Here, we investigated the clinical impact of TP53 mutations,MDM2SNP309 and TP53 codon 72 polymorphisms on survival in DLBCL of germinal center (GC) and non-GC subtypes. Thirteen of the 102 (12.7%) patients displayed TP53 mutations. Overall, TP53 mutations had a significant effect on lymphoma-specific survival (LSS, P = 0.009) and progression-free survival (PFS, P = 0.028). In particular, inferior survival was observed in TP53-mutated DLBCLs of GC subtype (LSS, P = 0.002 and PFS, P = 0.006). Neither MDM2 SNP309 nor the TP53 codon 72 polymorphism had an impact on age of onset or survival. Altogether, our data suggests that TP53 mutations are associated with poor outcome in GC-DLBCL patients.
format Article
author Zainuddin, Norafiza
Berglund, Mattias
Wanders, Alkwin
Ren, Zhi-Ping
Amini, Rose-Marie
Lindell, Monica
Kanduri, Meena
Roos, Göran
Rosenquist, Richard
Enblad, Gunilla
author_facet Zainuddin, Norafiza
Berglund, Mattias
Wanders, Alkwin
Ren, Zhi-Ping
Amini, Rose-Marie
Lindell, Monica
Kanduri, Meena
Roos, Göran
Rosenquist, Richard
Enblad, Gunilla
author_sort Zainuddin, Norafiza
title TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype
title_short TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype
title_full TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype
title_fullStr TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype
title_full_unstemmed TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype
title_sort tp53 mutations predict for poor survival in de novo diffuse large b-cell lymphoma of germinal center subtype
publisher Elsevier Limited
publishDate 2008
url http://irep.iium.edu.my/29949/
http://irep.iium.edu.my/29949/
http://irep.iium.edu.my/29949/
http://irep.iium.edu.my/29949/1/Preview_of_%E2%80%9CUntitled_Document%E2%80%9D_tp53.pdf
first_indexed 2023-09-18T20:43:58Z
last_indexed 2023-09-18T20:43:58Z
_version_ 1777409550689763328

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