Vaccination: potential adverse effects and future challenges

Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related research, we have analyzed the possible changes in homeostasis of the haematopoieti...

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Main Authors:	Aziz, Jazli, Rahman, Mohammad Tariqur
Format:	Article
Language:	English
Published:	Kulliyyah of Science, IIUM 2011
Subjects:	RM Therapeutics. Pharmacology
Online Access:	http://irep.iium.edu.my/29726/ http://irep.iium.edu.my/29726/ http://irep.iium.edu.my/29726/1/Vaccination.pdf

id	iium-29726
recordtype	eprints
spelling	iium-297262013-07-31T01:26:05Z http://irep.iium.edu.my/29726/ Vaccination: potential adverse effects and future challenges Aziz, Jazli Rahman, Mohammad Tariqur RM Therapeutics. Pharmacology Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related research, we have analyzed the possible changes in homeostasis of the haematopoietic system in terms of level of antibody (Ab) after vaccination. Several vaccines were reported to increase a wide range of total Ab concentration such as <0.01%-2.40% in children and 0.02%-1.65% in adults. Reported increased level of IgG against Haemophilus influenza type-B was recorded as 605-1210 folds higher in children and 1226-2453 folds higher in adults than the required protective levels. Similar changes were also observed for other vaccines. Such increased level of total Abs at least theoretically can contribute to higher concentration of protein i.e., hyperproteinemia in blood. Since Ab is a polymer of amino acids; therefore hyperproteinemia due to increased level of Ab may in turn affect pH and osmosis of the blood. Therefore, an optimum dose of vaccine(s) for sufficient boost of immune mechanisms, rather than a dose required for highest efficiency, is recommended before an individual is vaccinated. Kulliyyah of Science, IIUM 2011 Article PeerReviewed application/pdf en http://irep.iium.edu.my/29726/1/Vaccination.pdf Aziz, Jazli and Rahman, Mohammad Tariqur (2011) Vaccination: potential adverse effects and future challenges. Revelation and Science, 1 (2). pp. 25-33. ISSN 2229-9947 http://www.iium.edu.my/revival/index.php/revival/article/view/28
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RM Therapeutics. Pharmacology
spellingShingle	RM Therapeutics. Pharmacology Aziz, Jazli Rahman, Mohammad Tariqur Vaccination: potential adverse effects and future challenges
description	Concerns over potential adverse effects of vaccination have been raised with the aim to develop and design efficient yet harmless vaccines. Using data derived from the reported vaccine efficiency trials and related research, we have analyzed the possible changes in homeostasis of the haematopoietic system in terms of level of antibody (Ab) after vaccination. Several vaccines were reported to increase a wide range of total Ab concentration such as <0.01%-2.40% in children and 0.02%-1.65% in adults. Reported increased level of IgG against Haemophilus influenza type-B was recorded as 605-1210 folds higher in children and 1226-2453 folds higher in adults than the required protective levels. Similar changes were also observed for other vaccines. Such increased level of total Abs at least theoretically can contribute to higher concentration of protein i.e., hyperproteinemia in blood. Since Ab is a polymer of amino acids; therefore hyperproteinemia due to increased level of Ab may in turn affect pH and osmosis of the blood. Therefore, an optimum dose of vaccine(s) for sufficient boost of immune mechanisms, rather than a dose required for highest efficiency, is recommended before an individual is vaccinated.
format	Article
author	Aziz, Jazli Rahman, Mohammad Tariqur
author_facet	Aziz, Jazli Rahman, Mohammad Tariqur
author_sort	Aziz, Jazli
title	Vaccination: potential adverse effects and future challenges
title_short	Vaccination: potential adverse effects and future challenges
title_full	Vaccination: potential adverse effects and future challenges
title_fullStr	Vaccination: potential adverse effects and future challenges
title_full_unstemmed	Vaccination: potential adverse effects and future challenges
title_sort	vaccination: potential adverse effects and future challenges
publisher	Kulliyyah of Science, IIUM
publishDate	2011
url	http://irep.iium.edu.my/29726/ http://irep.iium.edu.my/29726/ http://irep.iium.edu.my/29726/1/Vaccination.pdf
first_indexed	2023-09-18T20:43:41Z
last_indexed	2023-09-18T20:43:41Z
_version_	1777409533179592704

Vaccination: potential adverse effects and future challenges

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