Synthesis, characterization and antibacterial activity of Schiff base derived from S-methyldithiocarbazate and methylisatin
New tridentate nitrogen–oxygen–sulfur Schiff base has been prepared from the condensation reaction of S-methyldithiocarbazate and methylisatin. The compound crystallized in triclinic crystal system with space group P - 1, Z = 2, V = 612.92(3) A ° 3 and unit cell parameters a = 6.8540(2) A ° , b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerLink
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/ http://irep.iium.edu.my/29405/1/JOCC_42%282%29_2012.pdf |
| Summary: | New tridentate nitrogen–oxygen–sulfur Schiff
base has been prepared from the condensation reaction of
S-methyldithiocarbazate and methylisatin. The compound
crystallized in triclinic crystal system with space group
P - 1, Z = 2, V = 612.92(3) A ° 3 and unit cell parameters
a = 6.8540(2) A ° , b = 8.3022(2) A ° , c = 11.5243(4) A ° ,
a = 79.8186(13)�, b = 90.5224(14)� and c = 72.1362(13)�.
Crystal structure reveals that the compound exists in the
thione form with the methylisatin moiety is trans with
respect to the C3–N2 and C3–S4 bonds whereas the methyl
group of the dithiocarbazate moiety is cis with respect to the C3–N2 and C3–S5 bonds. The Schiff base was found to be
selectively active against the selected Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus)with the inhibition zones of 16 and 12 mm, respectively. |
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