Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM

Introduction: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on the microscopic marginal status...

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Main Authors:	Sharifudin, Mohd Ariff, Wan, Zulmi, Wan Ismail, Wan Faisham Numan, Mat Zin, Nor Azman, Mohamed Amir, Nawaz Hussain
Format:	Conference or Workshop Item
Language:	English English English English
Published:	2012
Subjects:	RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics
Online Access:	http://irep.iium.edu.my/29372/ http://irep.iium.edu.my/29372/ http://irep.iium.edu.my/29372/1/APMSTS_2012_-_DrMohdAriffS_-_Poster_Presentation.pdf http://irep.iium.edu.my/29372/2/APMSTS_2012_-_Cover.pdf http://irep.iium.edu.my/29372/3/APMSTS_2012_-_Poster_Presentation.pdf http://irep.iium.edu.my/29372/4/APMSTS_2012_-_A1228_%28Dr_Mohd_Ariff_Sharifudin%29.pdf

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spelling	iium-293722013-03-04T01:43:46Z http://irep.iium.edu.my/29372/ Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics Introduction: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on the microscopic marginal status. Patients and Methods: We analyzed 64 cases of pelvic tumours of various types underwent hemipelvectomy in HUSM throughout a 10-year between year 2001 till 2010. Various clinicopathologic factors were analyzed in relation to the oncologic outcomes of local recurrence, distant metastasis, and disease-specific death. Results: Mean age at time of surgery was 39.84 years (range 8 to 79 years). Majority of cases were primary tumours (76.56%). Chondrosarcoma (n = 14) and osteosarcoma (n = 13) were the most common diagnoses. There were 10 cases of stage IB tumour, 4 cases of stage IIA, 19 cases of stage IIB, and 22 cases of stage III. Twenty-three patients underwent external hemipelvectomy and 35 patients subjected for internal hemipelvectomy of various types of resections. Majority (71.88%) of cases were treated with curative intention. Fourteen of 37 cases (37.84%) attempted for wide resection came back as having positive microscopic margins. Incidence of positive microscopic margin was higher in cases with wide contaminated margins, in which 56.25% of cases had a positive microscopic margin. Our results showed local and distant recurrence rate were higher when margins were positive. But paradoxically the disease-specific death rate was lower in cases with positive margins. Conclusion: Microscopic margin was a prognostic factor for all three primary endpoints of this study, but was not statistically significant. Other prognostic factors for survival include stage of tumour, histological diagnosis, and types of surgery. 2012-09-09 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/29372/1/APMSTS_2012_-_DrMohdAriffS_-_Poster_Presentation.pdf application/pdf en http://irep.iium.edu.my/29372/2/APMSTS_2012_-_Cover.pdf application/pdf en http://irep.iium.edu.my/29372/3/APMSTS_2012_-_Poster_Presentation.pdf application/pdf en http://irep.iium.edu.my/29372/4/APMSTS_2012_-_A1228_%28Dr_Mohd_Ariff_Sharifudin%29.pdf Sharifudin, Mohd Ariff and Wan, Zulmi and Wan Ismail, Wan Faisham Numan and Mat Zin, Nor Azman and Mohamed Amir, Nawaz Hussain (2012) Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM. In: 9th Asia-Pacific Musculoskeletal Tumour Society Meeting 2012, 6-9 September 2012, Hilton Kuala Lumpur, Kuala Lumpur. http://www.apmsts2012.com/
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English English English English
topic	RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics
spellingShingle	RB Pathology RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD701 Orthopedics Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM
description	Introduction: Safe surgical margins are difficult to achieve when performing surgical resections for bone and soft tissue tumours involving the pelvis. We evaluated whether safe surgical margins could be achieved and if oncological outcomes could be predicted based on the microscopic marginal status. Patients and Methods: We analyzed 64 cases of pelvic tumours of various types underwent hemipelvectomy in HUSM throughout a 10-year between year 2001 till 2010. Various clinicopathologic factors were analyzed in relation to the oncologic outcomes of local recurrence, distant metastasis, and disease-specific death. Results: Mean age at time of surgery was 39.84 years (range 8 to 79 years). Majority of cases were primary tumours (76.56%). Chondrosarcoma (n = 14) and osteosarcoma (n = 13) were the most common diagnoses. There were 10 cases of stage IB tumour, 4 cases of stage IIA, 19 cases of stage IIB, and 22 cases of stage III. Twenty-three patients underwent external hemipelvectomy and 35 patients subjected for internal hemipelvectomy of various types of resections. Majority (71.88%) of cases were treated with curative intention. Fourteen of 37 cases (37.84%) attempted for wide resection came back as having positive microscopic margins. Incidence of positive microscopic margin was higher in cases with wide contaminated margins, in which 56.25% of cases had a positive microscopic margin. Our results showed local and distant recurrence rate were higher when margins were positive. But paradoxically the disease-specific death rate was lower in cases with positive margins. Conclusion: Microscopic margin was a prognostic factor for all three primary endpoints of this study, but was not statistically significant. Other prognostic factors for survival include stage of tumour, histological diagnosis, and types of surgery.
format	Conference or Workshop Item
author	Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain
author_facet	Sharifudin, Mohd Ariff Wan, Zulmi Wan Ismail, Wan Faisham Numan Mat Zin, Nor Azman Mohamed Amir, Nawaz Hussain
author_sort	Sharifudin, Mohd Ariff
title	Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM
title_short	Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM
title_full	Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM
title_fullStr	Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM
title_full_unstemmed	Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM
title_sort	surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in husm
publishDate	2012
url	http://irep.iium.edu.my/29372/ http://irep.iium.edu.my/29372/ http://irep.iium.edu.my/29372/1/APMSTS_2012_-_DrMohdAriffS_-_Poster_Presentation.pdf http://irep.iium.edu.my/29372/2/APMSTS_2012_-_Cover.pdf http://irep.iium.edu.my/29372/3/APMSTS_2012_-_Poster_Presentation.pdf http://irep.iium.edu.my/29372/4/APMSTS_2012_-_A1228_%28Dr_Mohd_Ariff_Sharifudin%29.pdf
first_indexed	2023-09-18T20:43:06Z
last_indexed	2023-09-18T20:43:06Z
_version_	1777409496742625280

Surgical margins and oncologic outcomes of tumour-related hemipelvectomies for bone and soft tissue tumours in HUSM

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