β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications
We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe 3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the n...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd.
2013
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/29307/ http://irep.iium.edu.my/29307/ http://irep.iium.edu.my/29307/1/shahab__%CE%B2-Cyclodextrin_1-s2.0-S0144861713001859-main.pdf |
| Summary: | We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe 3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery. |
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