The protective effect of hibiscus sabdariffa towards liver toxicity
This study was carried out to investigate the effect of Hibiscus sabdariffa or roselle on the progression of acute liver injury in rats. The liver injury was induced by administration of 1000 mg/kg acetaminophen intraperitoneally and aqueous extract at low (500 mg/kg) and high (1000 mg/kg) doses...
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2007
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| Online Access: | http://irep.iium.edu.my/29282/ http://irep.iium.edu.my/29282/4/The_Protective_Effects_of_Hibiscus_sabdariffa.pdf |
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iium-29282 |
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eprints |
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iium-292822013-06-25T11:18:01Z http://irep.iium.edu.my/29282/ The protective effect of hibiscus sabdariffa towards liver toxicity Ahmad Raus, Raha Mohd-Isa, Emy Sazri Q Science (General) R Medicine (General) This study was carried out to investigate the effect of Hibiscus sabdariffa or roselle on the progression of acute liver injury in rats. The liver injury was induced by administration of 1000 mg/kg acetaminophen intraperitoneally and aqueous extract at low (500 mg/kg) and high (1000 mg/kg) doses of H. sabdariffa was given to rats by force feeding. H. sabdariffa in the diet showed no significant effect on the liver marker enzymes, alanin transaminase (ALT) plus malonaldehyde (MDA) and reduced glutathione (GSH) except for glutathione S-transferase (GST). Interestingly, increased levels of ALT, GST and MDA plus significant reduction of GSH in acetaminophen treated rats were counteracted by the administration of H. sabdariffa. The effect of H. sabdariffa is dose-dependent as higher administrative dose of the plant extract to the acetaminophen treated rats resulted in further liver protective effects. Histopathologically H. sabdariffa reduced the incidence of liver damage. This study showed that the aqueous extract of H. sabdariffa had significant protective effect towards hepatotoxicity. 2007 Conference or Workshop Item PeerReviewed application/pdf en http://irep.iium.edu.my/29282/4/The_Protective_Effects_of_Hibiscus_sabdariffa.pdf Ahmad Raus, Raha and Mohd-Isa, Emy Sazri (2007) The protective effect of hibiscus sabdariffa towards liver toxicity. In: International Conference on WHAT Medicine III, 16 - 17 November 2007, Kuala Lumpur. |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
International Islamic University Malaysia |
| building |
IIUM Repository |
| collection |
Online Access |
| language |
English |
| topic |
Q Science (General) R Medicine (General) |
| spellingShingle |
Q Science (General) R Medicine (General) Ahmad Raus, Raha Mohd-Isa, Emy Sazri The protective effect of hibiscus sabdariffa towards liver toxicity |
| description |
This study was carried out to investigate the effect of Hibiscus sabdariffa or roselle on
the progression of acute liver injury in rats. The liver injury was induced by
administration of 1000 mg/kg acetaminophen intraperitoneally and aqueous extract at
low (500 mg/kg) and high (1000 mg/kg) doses of H. sabdariffa was given to rats by
force feeding. H. sabdariffa in the diet showed no significant effect on the liver
marker enzymes, alanin transaminase (ALT) plus malonaldehyde (MDA) and reduced
glutathione (GSH) except for glutathione S-transferase (GST). Interestingly, increased
levels of ALT, GST and MDA plus significant reduction of GSH in acetaminophen
treated rats were counteracted by the administration of H. sabdariffa. The effect of H.
sabdariffa is dose-dependent as higher administrative dose of the plant extract to the
acetaminophen treated rats resulted in further liver protective effects.
Histopathologically H. sabdariffa reduced the incidence of liver damage. This study
showed that the aqueous extract of H. sabdariffa had significant protective effect
towards hepatotoxicity. |
| format |
Conference or Workshop Item |
| author |
Ahmad Raus, Raha Mohd-Isa, Emy Sazri |
| author_facet |
Ahmad Raus, Raha Mohd-Isa, Emy Sazri |
| author_sort |
Ahmad Raus, Raha |
| title |
The protective effect of hibiscus sabdariffa towards liver toxicity |
| title_short |
The protective effect of hibiscus sabdariffa towards liver toxicity |
| title_full |
The protective effect of hibiscus sabdariffa towards liver toxicity |
| title_fullStr |
The protective effect of hibiscus sabdariffa towards liver toxicity |
| title_full_unstemmed |
The protective effect of hibiscus sabdariffa towards liver toxicity |
| title_sort |
protective effect of hibiscus sabdariffa towards liver toxicity |
| publishDate |
2007 |
| url |
http://irep.iium.edu.my/29282/ http://irep.iium.edu.my/29282/4/The_Protective_Effects_of_Hibiscus_sabdariffa.pdf |
| first_indexed |
2023-09-18T20:42:58Z |
| last_indexed |
2023-09-18T20:42:58Z |
| _version_ |
1777409487685025792 |