The influence of premenopausal hystrectomy on bone mineral density
Objective: To investigate whether premenopausal hysterectomy has an effect on bone mass in women in their fifties . Methods: This cross-sectional study was performed on 25 healthy women who had premenopausal hysterectomy before the age of 45 and at least 2 years before the study with 40 healthy...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ireland Ltd.
2012
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/29266/ http://irep.iium.edu.my/29266/ http://irep.iium.edu.my/29266/ http://irep.iium.edu.my/29266/1/The_influence_of_premenopausal.pdf |
| Summary: | Objective: To investigate whether premenopausal hysterectomy
has an effect on bone mass in women in their fifties .
Methods: This cross-sectional study was performed on 25 healthy
women who had premenopausal hysterectomy before the age of
45 and at least 2 years before the study with 40 healthy natural
postmenopausal women 45–60 years old. Evaluation of the
menopausal state was done by measuring serum follicular
stimulating hormone and serum estradiol. Bone mineral density of
the left proximal femur was determined by dual energy X-ray
absorptiometry in six regions (femoral neck, greater trochanter,
interochantric, ward‘s triangle, shaft, total hip region). Evaluation
of bone remodeling done by measuring serum alkaline
phosphotase. The result of both groups were compared.
Results: The study showed slight increment of BMD among cases
with hysterectomy than the control group by an amount ranging
between 1.9% in the femoral shaft to 4.8% in the greater
trochanter and ward‘s triangle. These differences were not
statistically significant and even when they were exceptionally
significant as the case with BMD of the femoral neck and
intertrochantric area they were too small in magnitude to be of
clinical relevance.
Conclusion: Hysterectomy had no impact on bone parameters
even after adjusting for the duration of menopause. |
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