Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma

Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma

Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal ute...

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Main Authors: Yi, Wang, Jun-Ichiro, Ikeda, ., Nur Rahadiani, Mamat, Suhana, Ueda, Yutaka, Tian, Tian, Enomoto, Takayuki, Kimura, Tadashi, Aozasa, Katsuyuki, Morii, Eiichi
Format: Article
Language:English
Published: Spandidos Publications 2012
Subjects:
QM Human anatomy
Online Access:http://irep.iium.edu.my/29238/
http://irep.iium.edu.my/29238/
http://irep.iium.edu.my/29238/
http://irep.iium.edu.my/29238/1/Prognostic_significance_of_elongator_protein_3_expression_in_endometrioid_adenocarcinoma.pdf
id iium-29238
recordtype eprints
spelling iium-292382013-03-14T01:37:27Z http://irep.iium.edu.my/29238/ Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma Yi, Wang Jun-Ichiro, Ikeda ., Nur Rahadiani Mamat, Suhana Ueda, Yutaka Tian, Tian Enomoto, Takayuki Kimura, Tadashi Aozasa, Katsuyuki Morii, Eiichi QM Human anatomy Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uterine endometrioid adenocarcinoma tissue. ELP3 was abundantly expressed in both the proliferative and secretory phases of the endometrial cycle. However, ELP3 expression levels varied among cases of endometrioid adenocarcinoma. In patients with endometrioid adenocarcinoma, a low ELP3 expression was correlated to a high T-factor (p=0.036), tumor stage (p=0.001), lymph node metastasis (p<0.001), resistance to chemotherapy (p=0.045), recurrence (p=0.004) and poor prognosis (p=0.003). Univariate and multivariate analyses revealed that a low ELP3 expression was an independent factor for poor prognosis. In conclusion, this is the first study to examine the clinical implications of ELP3 expression in cancer. Spandidos Publications 2012-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/29238/1/Prognostic_significance_of_elongator_protein_3_expression_in_endometrioid_adenocarcinoma.pdf Yi, Wang and Jun-Ichiro, Ikeda and ., Nur Rahadiani and Mamat, Suhana and Ueda, Yutaka and Tian, Tian and Enomoto, Takayuki and Kimura, Tadashi and Aozasa, Katsuyuki and Morii, Eiichi (2012) Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma. Oncology Letters, 3 (1). pp. 25-29. ISSN 1792-1082 (O), 1792-1074 (P) http://www.spandidos-publications.com/ol/3/1/25 10.3892/ol.2011.428
repository_type Digital Repository
institution_category Local University
institution International Islamic University Malaysia
building IIUM Repository
collection Online Access
language English
topic QM Human anatomy
spellingShingle QM Human anatomy
Yi, Wang
Jun-Ichiro, Ikeda
., Nur Rahadiani
Mamat, Suhana
Ueda, Yutaka
Tian, Tian
Enomoto, Takayuki
Kimura, Tadashi
Aozasa, Katsuyuki
Morii, Eiichi
Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
description Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uterine endometrioid adenocarcinoma tissue. ELP3 was abundantly expressed in both the proliferative and secretory phases of the endometrial cycle. However, ELP3 expression levels varied among cases of endometrioid adenocarcinoma. In patients with endometrioid adenocarcinoma, a low ELP3 expression was correlated to a high T-factor (p=0.036), tumor stage (p=0.001), lymph node metastasis (p<0.001), resistance to chemotherapy (p=0.045), recurrence (p=0.004) and poor prognosis (p=0.003). Univariate and multivariate analyses revealed that a low ELP3 expression was an independent factor for poor prognosis. In conclusion, this is the first study to examine the clinical implications of ELP3 expression in cancer.
format Article
author Yi, Wang
Jun-Ichiro, Ikeda
., Nur Rahadiani
Mamat, Suhana
Ueda, Yutaka
Tian, Tian
Enomoto, Takayuki
Kimura, Tadashi
Aozasa, Katsuyuki
Morii, Eiichi
author_facet Yi, Wang
Jun-Ichiro, Ikeda
., Nur Rahadiani
Mamat, Suhana
Ueda, Yutaka
Tian, Tian
Enomoto, Takayuki
Kimura, Tadashi
Aozasa, Katsuyuki
Morii, Eiichi
author_sort Yi, Wang
title Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
title_short Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
title_full Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
title_fullStr Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
title_full_unstemmed Prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
title_sort prognostic significance of elongator protein 3 expression in endometrioid adenocarcinoma
publisher Spandidos Publications
publishDate 2012
url http://irep.iium.edu.my/29238/
http://irep.iium.edu.my/29238/
http://irep.iium.edu.my/29238/
http://irep.iium.edu.my/29238/1/Prognostic_significance_of_elongator_protein_3_expression_in_endometrioid_adenocarcinoma.pdf
first_indexed 2023-09-18T20:42:54Z
last_indexed 2023-09-18T20:42:54Z
_version_ 1777409483658493952

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