Does retinal vascular geometry vary with cardiac cycle?

Purpose. Changes in retinal vascular parameters have been shown to be associated with systemic vascular diseases. In this study, we assessed the physiologic variations in retinal vascular measurements during the cardiac cycle. Methods. Fundus images were taken using electrocardiogram-synchron...

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Main Authors:	Hao, Hao, Sasongko, Muhammad, Tien, Y. Wong, Che Azemin, Mohd. Zulfaezal, Aliahmad, Behzad, Hodgson, Lauren, Kawasaki, Ryo, Carol, Y. Cheung, Jie, Jin Wang, Kumar, Dinesh Kant
Format:	Article
Language:	English
Published:	The Association for Research in Vision and Ophthalmology, Inc. 2012
Subjects:	RE Ophthalmology
Online Access:	http://irep.iium.edu.my/28962/ http://irep.iium.edu.my/28962/ http://irep.iium.edu.my/28962/ http://irep.iium.edu.my/28962/1/Does_Retinal_Vascular_Geometry.pdf

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spelling	iium-289622013-03-18T08:32:18Z http://irep.iium.edu.my/28962/ Does retinal vascular geometry vary with cardiac cycle? Hao, Hao Sasongko, Muhammad Tien, Y. Wong Che Azemin, Mohd. Zulfaezal Aliahmad, Behzad Hodgson, Lauren Kawasaki, Ryo Carol, Y. Cheung Jie, Jin Wang Kumar, Dinesh Kant RE Ophthalmology Purpose. Changes in retinal vascular parameters have been shown to be associated with systemic vascular diseases. In this study, we assessed the physiologic variations in retinal vascular measurements during the cardiac cycle. Methods. Fundus images were taken using electrocardiogram-synchronized retinal camera at nine distinct cardiac points from 15 healthy volunteers (135 images). Analyses of retinal vessel geometric measures, including retinal vessel caliber (individual and summary), tortuosity, branching angle, length–diameter ratio (LDR), and optimality deviation, were performed using semiautomated computer software. Repeated-measures ANOVAs were used to obtain the means and to estimate the variation of each cardiac point compared with cardiac point 1. Results. There was a significant variation of the caliber of the individual arteriolar and venular vessels. However, there was no significant variation found for vessel caliber summary, represented by the central retinal arteriolar equivalent (CRAE) and the central retinal venular equivalent (CRVE). There was also no significant variation found for tortuosity and branching angle, and LDR showed none or very little variations at different cardiac points: variations in caliber ranges between 0 and 4.1%, tortuosity 0 and 1.5%, branching angle 0 and 3.5%, and LDR 0 and 2%; all values for variations, P > 0.1; linear trend, P > 0.5; and nonlinear trend, P > 0.8. Conclusions. This study showed that there were minimal variations in the CRAE, CRVE, tortuosity, and branching angle that are clinically used for two-dimensional measures of retinal vascular geometry during cardiac cycles. However, there was significant variation in the caliber of the individual vessels over the cardiac cycle. The Association for Research in Vision and Ophthalmology, Inc. 2012-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28962/1/Does_Retinal_Vascular_Geometry.pdf Hao, Hao and Sasongko, Muhammad and Tien, Y. Wong and Che Azemin, Mohd. Zulfaezal and Aliahmad, Behzad and Hodgson, Lauren and Kawasaki, Ryo and Carol, Y. Cheung and Jie, Jin Wang and Kumar, Dinesh Kant (2012) Does retinal vascular geometry vary with cardiac cycle? Investigative Ophthalmology & Visual Science, 53 (9). pp. 5799-5805. ISSN 0146-0404 http://www.iovs.org/content/53/9/5799.abstract 10.1167/iovs.11-9326
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RE Ophthalmology
spellingShingle	RE Ophthalmology Hao, Hao Sasongko, Muhammad Tien, Y. Wong Che Azemin, Mohd. Zulfaezal Aliahmad, Behzad Hodgson, Lauren Kawasaki, Ryo Carol, Y. Cheung Jie, Jin Wang Kumar, Dinesh Kant Does retinal vascular geometry vary with cardiac cycle?
description	Purpose. Changes in retinal vascular parameters have been shown to be associated with systemic vascular diseases. In this study, we assessed the physiologic variations in retinal vascular measurements during the cardiac cycle. Methods. Fundus images were taken using electrocardiogram-synchronized retinal camera at nine distinct cardiac points from 15 healthy volunteers (135 images). Analyses of retinal vessel geometric measures, including retinal vessel caliber (individual and summary), tortuosity, branching angle, length–diameter ratio (LDR), and optimality deviation, were performed using semiautomated computer software. Repeated-measures ANOVAs were used to obtain the means and to estimate the variation of each cardiac point compared with cardiac point 1. Results. There was a significant variation of the caliber of the individual arteriolar and venular vessels. However, there was no significant variation found for vessel caliber summary, represented by the central retinal arteriolar equivalent (CRAE) and the central retinal venular equivalent (CRVE). There was also no significant variation found for tortuosity and branching angle, and LDR showed none or very little variations at different cardiac points: variations in caliber ranges between 0 and 4.1%, tortuosity 0 and 1.5%, branching angle 0 and 3.5%, and LDR 0 and 2%; all values for variations, P > 0.1; linear trend, P > 0.5; and nonlinear trend, P > 0.8. Conclusions. This study showed that there were minimal variations in the CRAE, CRVE, tortuosity, and branching angle that are clinically used for two-dimensional measures of retinal vascular geometry during cardiac cycles. However, there was significant variation in the caliber of the individual vessels over the cardiac cycle.
format	Article
author	Hao, Hao Sasongko, Muhammad Tien, Y. Wong Che Azemin, Mohd. Zulfaezal Aliahmad, Behzad Hodgson, Lauren Kawasaki, Ryo Carol, Y. Cheung Jie, Jin Wang Kumar, Dinesh Kant
author_facet	Hao, Hao Sasongko, Muhammad Tien, Y. Wong Che Azemin, Mohd. Zulfaezal Aliahmad, Behzad Hodgson, Lauren Kawasaki, Ryo Carol, Y. Cheung Jie, Jin Wang Kumar, Dinesh Kant
author_sort	Hao, Hao
title	Does retinal vascular geometry vary with cardiac cycle?
title_short	Does retinal vascular geometry vary with cardiac cycle?
title_full	Does retinal vascular geometry vary with cardiac cycle?
title_fullStr	Does retinal vascular geometry vary with cardiac cycle?
title_full_unstemmed	Does retinal vascular geometry vary with cardiac cycle?
title_sort	does retinal vascular geometry vary with cardiac cycle?
publisher	The Association for Research in Vision and Ophthalmology, Inc.
publishDate	2012
url	http://irep.iium.edu.my/28962/ http://irep.iium.edu.my/28962/ http://irep.iium.edu.my/28962/ http://irep.iium.edu.my/28962/1/Does_Retinal_Vascular_Geometry.pdf
first_indexed	2023-09-18T20:42:31Z
last_indexed	2023-09-18T20:42:31Z
_version_	1777409460277346304

Does retinal vascular geometry vary with cardiac cycle?

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