Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy

Treatment with antiepileptic drugs is commonly guided by serum level monitoring. Such monitoring requires expensive laboratory equipment and products. However, well-conducted studies on the cost-effectiveness of therapeutic drug monitoring for antiepileptic drugs are lacking particularly in patients...

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Main Authors:	Saliha, Muhammad R.M., Bahari, Mohd. Baidi, Shafie, Asrul Akmal, Ahmad Hassalic, Mohamed Azmi, Baderaldeen , Omer Qutaiba, Abd, Arwa Y., Ganesan, Vigneswari M.
Format:	Article
Language:	English
Published:	Elsevier Inc. 2012
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/28908/ http://irep.iium.edu.my/28908/ http://irep.iium.edu.my/28908/ http://irep.iium.edu.my/28908/1/Omer_cost_effectiveness_analysis.pdf

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spelling	iium-289082013-06-25T05:44:33Z http://irep.iium.edu.my/28908/ Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy Saliha, Muhammad R.M. Bahari, Mohd. Baidi Shafie, Asrul Akmal Ahmad Hassalic, Mohamed Azmi Baderaldeen , Omer Qutaiba Abd, Arwa Y. Ganesan, Vigneswari M. RS Pharmacy and materia medica Treatment with antiepileptic drugs is commonly guided by serum level monitoring. Such monitoring requires expensive laboratory equipment and products. However, well-conducted studies on the cost-effectiveness of therapeutic drug monitoring for antiepileptic drugs are lacking particularly in patients with structural-metabolic epilepsy. The study aims to assess the cost-effectiveness of serum level monitoring services in the management of children with structural-metabolic epilepsy during the first year of diagnosis. A retrospective cost-effectiveness analysis was conducted from the provider perspective. It included patients attended a paediatric neurology clinic. The effectiveness measures used in this analysis were the number of patients that achieved ≥50% reduction in seizure frequency, and the number of patients with 3-month seizure free. Medical records of the patients were reviewed for the required information. Medical chart/billing data obtained from the hospital were collected to estimate the resources used (One Malaysian Ringgit MYR is equivalent to 0.31 USD). The recruited children were followed for one year following their first visit. The average cost effectiveness ratio for the monitored patients (MYR 2735 per patient that achieved a ≥50% reduction in seizure frequency) was lower than that for non-monitored patients (MYR 2921 per patients that achieved a ≥50% reduction in seizure frequency), with incremental cost-effectiveness ratio of MYR 2357 per one additional patient that achieved a ≥50% reduction in seizure frequency. The average cost effectiveness ratios for monitored and non-monitored group were MYR 8279 and MYR 6433 per patient with a 3-month seizure-free period, respectively, with incremental cost-effectiveness ratio of MYR 29,666 per one additional patient with a 3-month seizure-free period. In terms of the effectiveness measures used, serum level monitoring of antiepileptic drugs was found to be cost-effective. However, the incremental cost-effectiveness ratio was found to be sensitive to the cost of management. Elsevier Inc. 2012-03 Article PeerReviewed application/pdf en http://irep.iium.edu.my/28908/1/Omer_cost_effectiveness_analysis.pdf Saliha, Muhammad R.M. and Bahari, Mohd. Baidi and Shafie, Asrul Akmal and Ahmad Hassalic, Mohamed Azmi and Baderaldeen , Omer Qutaiba and Abd, Arwa Y. and Ganesan, Vigneswari M. (2012) Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy. Epilepsy Research, 104 (1). pp. 151-157. ISSN 0920-1211 http://www.sciencedirect.com/science/article/pii/S092012111200280X 10.1016/j.eplepsyres.2012.09.012
repository_type	Digital Repository
institution_category	Local University
institution	International Islamic University Malaysia
building	IIUM Repository
collection	Online Access
language	English
topic	RS Pharmacy and materia medica
spellingShingle	RS Pharmacy and materia medica Saliha, Muhammad R.M. Bahari, Mohd. Baidi Shafie, Asrul Akmal Ahmad Hassalic, Mohamed Azmi Baderaldeen , Omer Qutaiba Abd, Arwa Y. Ganesan, Vigneswari M. Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy
description	Treatment with antiepileptic drugs is commonly guided by serum level monitoring. Such monitoring requires expensive laboratory equipment and products. However, well-conducted studies on the cost-effectiveness of therapeutic drug monitoring for antiepileptic drugs are lacking particularly in patients with structural-metabolic epilepsy. The study aims to assess the cost-effectiveness of serum level monitoring services in the management of children with structural-metabolic epilepsy during the first year of diagnosis. A retrospective cost-effectiveness analysis was conducted from the provider perspective. It included patients attended a paediatric neurology clinic. The effectiveness measures used in this analysis were the number of patients that achieved ≥50% reduction in seizure frequency, and the number of patients with 3-month seizure free. Medical records of the patients were reviewed for the required information. Medical chart/billing data obtained from the hospital were collected to estimate the resources used (One Malaysian Ringgit MYR is equivalent to 0.31 USD). The recruited children were followed for one year following their first visit. The average cost effectiveness ratio for the monitored patients (MYR 2735 per patient that achieved a ≥50% reduction in seizure frequency) was lower than that for non-monitored patients (MYR 2921 per patients that achieved a ≥50% reduction in seizure frequency), with incremental cost-effectiveness ratio of MYR 2357 per one additional patient that achieved a ≥50% reduction in seizure frequency. The average cost effectiveness ratios for monitored and non-monitored group were MYR 8279 and MYR 6433 per patient with a 3-month seizure-free period, respectively, with incremental cost-effectiveness ratio of MYR 29,666 per one additional patient with a 3-month seizure-free period. In terms of the effectiveness measures used, serum level monitoring of antiepileptic drugs was found to be cost-effective. However, the incremental cost-effectiveness ratio was found to be sensitive to the cost of management.
format	Article
author	Saliha, Muhammad R.M. Bahari, Mohd. Baidi Shafie, Asrul Akmal Ahmad Hassalic, Mohamed Azmi Baderaldeen , Omer Qutaiba Abd, Arwa Y. Ganesan, Vigneswari M.
author_facet	Saliha, Muhammad R.M. Bahari, Mohd. Baidi Shafie, Asrul Akmal Ahmad Hassalic, Mohamed Azmi Baderaldeen , Omer Qutaiba Abd, Arwa Y. Ganesan, Vigneswari M.
author_sort	Saliha, Muhammad R.M.
title	Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy
title_short	Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy
title_full	Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy
title_fullStr	Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy
title_full_unstemmed	Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy
title_sort	cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy
publisher	Elsevier Inc.
publishDate	2012
url	http://irep.iium.edu.my/28908/ http://irep.iium.edu.my/28908/ http://irep.iium.edu.my/28908/ http://irep.iium.edu.my/28908/1/Omer_cost_effectiveness_analysis.pdf
first_indexed	2023-09-18T20:42:28Z
last_indexed	2023-09-18T20:42:28Z
_version_	1777409456186851328

Cost-effectiveness analysis for the use of serum antiepileptic drug level monitoring in children diagnosed with structural-metabolic epilepsy

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